ACTH-independent macronodular adrenal hyperplasia: imaging findings of a rare condition : A case report

Abdom Imaging. 2008 Mar-Apr;33(2):225-9. doi: 10.1007/s00261-007-9236-y.

Abstract

Endogenous Cushing's syndrome is a relatively rare disease. Most cases being ACTH-dependent, ACTH-independent Cushing's syndrome (AICS) is an even rarer condition [15%-20%]. In more than 95% cases the cause of AICS is unilateral adrenal enlargement caused by adenoma or carcinoma. Bilateral adrenal disease is caused by primary pigmented nodular adrenal dysplasia (PPNAD) and ACTH-independent macro nodular hyperplasia (AIMAH). Only few case reports of the latter condition exist in the radiology literature, PPNAD being the commoner of two as the cause for AICS.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Glands / diagnostic imaging*
  • Adrenal Glands / pathology*
  • Adrenal Glands / surgery
  • Adrenocorticotropic Hormone*
  • Contrast Media / administration & dosage
  • Cushing Syndrome / diagnosis*
  • Cushing Syndrome / surgery
  • Diabetes Mellitus
  • Humans
  • Hypokalemia / etiology
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Radiographic Image Enhancement
  • Rare Diseases
  • Tomography, X-Ray Computed

Substances

  • Contrast Media
  • Adrenocorticotropic Hormone