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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1951 2
1954 2
1957 2
1960 3
1961 3
1962 2
1963 2
1964 1
1977 1
1979 1
1981 2
1982 1
1983 7
1984 55
1985 230
1986 309
1987 502
1988 569
1989 715
1990 946
1991 976
1992 1066
1993 1173
1994 1446
1995 1540
1996 1380
1997 1417
1998 1424
1999 1465
2000 1528
2001 1604
2002 1612
2003 1656
2004 1764
2005 1768
2006 1825
2007 1880
2008 1853
2009 1735
2010 1679
2011 1745
2012 1703
2013 1665
2014 1641
2015 1434
2016 1371
2017 1190
2018 1046
2019 493
2020 13
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43,172 results
Results by year
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Page 1
Eukaryotic core promoters and the functional basis of transcription initiation
Haberle V and Stark A. Nat Rev Mol Cell Biol 2018 - Review. PMID 29946135 Free PMC article.
They enable the highly regulated transcription of genes by selectively integrating regulatory cues from distal enhancers and their associated regulatory proteins. ...On the basis of the established properties of gene core promoters, we discuss transcription start sites within enhancers and integrate recent results obtained from dedicated functional assays to propose a functional model of transcription initiation. ...
They enable the highly regulated transcription of genes by selectively integrating regulatory cues from distal enhancers and t …
The core promoter: At the heart of gene expression.
Danino YM, et al. Biochim Biophys Acta 2015 - Review. PMID 25934543
Here, we discuss transcription initiation, diversity in core promoter composition, interactions of the basal transcription machinery with the core promoter, enhancer-promoter specificity, core promoter-preferential activation, enhancer RNAs, Pol II pausing, transcription termination, Pol II recycling and translation. ...Taken together, we review a broad spectrum of studies that highlight the importance of the core promoter and its pivotal role in the regulation of metazoan gene expression and suggest future research directions and challenges....
Here, we discuss transcription initiation, diversity in core promoter composition, interactions of the basal transcription machinery …
Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C.
Mifsud B, et al. Nat Genet 2015. PMID 25938943
Current chromosome conformation capture techniques do not offer sufficiently high resolution to interrogate these regulatory interactions on a genomic scale. ...This study provides new insights and accessible tools to dissect the regulatory interactions that underlie normal and aberrant gene regulation....
Current chromosome conformation capture techniques do not offer sufficiently high resolution to interrogate these regulatory i …
Systematic interrogation of human promoters
Weingarten-Gabbay S, et al. Genome Res 2019. PMID 30622120 Free PMC article.
We used this method to investigate thousands of native promoters and preinitiation complex (PIC) binding regions followed by in-depth characterization of the sequence motifs underlying promoter activity, including core promoter elements and TF binding sites. ...Overall, our study systematically assays the elements that drive expression in core and proximal promoter regions and sheds light on organization principles of regulatory regions in the human genome....
We used this method to investigate thousands of native promoters and preinitiation complex (PIC) binding regions followed by in-depth …
Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II.
Steurer B, et al. Proc Natl Acad Sci U S A 2018. PMID 29632207 Free PMC article.
Initiation and promoter-proximal pausing are key regulatory steps of RNA Polymerase II (Pol II) transcription. To study the in vivo dynamics of endogenous Pol II during these steps, we generated fully functional GFP-RPB1 knockin cells. ...Our live-cell-imaging approach provides insights into Pol II dynamics and suggests that the continuous release and reinitiation of promoter-bound Pol II is an important component of transcriptional regulation....
Initiation and promoter-proximal pausing are key regulatory steps of RNA Polymerase II (Pol II) transcription. To study …
Relationship between promoter sequence and its strength in gene expression.
Li J and Zhang Y. Eur Phys J E Soft Matter 2014. PMID 25260329
Promoter strength, or activity, is important in genetic engineering and synthetic biology. A constitutive promoter with a certain strength for one given RNA can often be reused for other RNAs. ...Meanwhile, nucleotides in different regions of promoter sequence have different effects on promoter strength. Based on experimental data for E. coli promoters, our calculations indicate that nucleotides in the -10 region, the -35 region, and the discriminator region of a promoter sequence are more important for determining promoter strength than those in the spacing region. ...
Promoter strength, or activity, is important in genetic engineering and synthetic biology. A constitutive promoter with a cert
A "Counter-Enhancer" in Tumor Suppression
Marchese FP and Huarte M. Cell 2018. PMID 29856950 Free article.
The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor....
The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism …
A double take on bivalent promoters
Voigt P, et al. Genes Dev 2013 - Review. Among authors: Reinberg D. PMID 23788621 Free PMC article.
Recent advances shed light on the establishment and function of bivalent domains; however, their role in development remains controversial, not least because suitable genetic models to probe their function in developing organisms are missing. Here, we explore avenues to and from bivalency and propose that bivalent domains and associated chromatin-modifying complexes safeguard proper and robust differentiation....
Recent advances shed light on the establishment and function of bivalent domains; however, their role in development remain
In the loop: promoter-enhancer interactions and bioinformatics.
Mora A, et al. Brief Bioinform 2016 - Review. PMID 26586731 Free PMC article.
Enhancer-promoter regulation is a fundamental mechanism underlying differential transcriptional regulation. Spatial chromatin organization brings remote enhancers in contact with target promoters in cis to regulate gene expression. There is considerable evidence for promoter-enhancer interactions (PEIs). In the recent years, genome-wide analyses have identified signatures and mapped novel enhancers; however, being able to precisely identify their target gene(s) requires massive biological and bioinformatics efforts. ...
Enhancer-promoter regulation is a fundamental mechanism underlying differential transcriptional regulation. Spatial chr …
Tetramethylpyrazine-Inducible Promoter Region from Rhodococcus jostii TMP1.
Stanislauskienė R, et al. Molecules 2018. PMID 29941849 Free PMC article.
An inducible promoter region, P(TTMP) (tetramethylpyrazine [TTMP]), has been identified upstream of the tpdABC operon, which contains the genes required for the initial degradation of 2,3,5,6-tetramethylpyrazine in Rhodococcus jostii TMP1 bacteria. ...The minimal promoter along with two 15 bp long direct repeats and two 7 bp inverted sequences were identified. Also, the influence of the promoter elements on the activity of P(TTMP) were determined using site-directed mutagenesis. ...
An inducible promoter region, P(TTMP) (tetramethylpyrazine [TTMP]), has been identified upstream of the tpdABC operon, which c …
43,172 results
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