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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1975 38
1976 51
1977 52
1978 59
1979 69
1980 90
1981 103
1982 105
1983 139
1984 174
1985 193
1986 170
1987 167
1988 127
1989 185
1990 186
1991 183
1992 181
1993 183
1994 197
1995 278
1996 338
1997 462
1998 525
1999 750
2000 924
2001 1138
2002 1379
2003 1512
2004 1599
2005 998
2006 206
2007 204
2008 177
2009 153
2010 171
2011 146
2012 126
2013 114
2014 124
2015 112
2016 88
2017 86
2018 83
2019 49
2020 0
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13,940 results
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Page 1
Prostaglandin synthases: Molecular characterization and involvement in prostaglandin biosynthesis.
Seo MJ and Oh DK. Prog Lipid Res 2017 - Review. PMID 28392405
Prostaglandins (PGs) belong to a subclass of eicosanoids and are classified based on the structures of the cyclopentane ring and their number of double bonds in their hydrocarbon structures. ...The biosynthesis of diverse PGs from unsaturated C20 fatty acids containing at least three double bonds such as dihomo-γ-linoleic acid (20:3(Δ8Z,11Z,14Z)), arachidonic acid (20:4(Δ5Z,8Z,11Z,14Z)), and eicosapentaenoic acid (20:5(Δ5Z,8Z,11Z,14Z,17Z)) is enables by various PG synthases, including prostaglandin H synthase (PGHS), 15-hydroxyprostaglandin dehydrogenase (15-HPGD), PGES, PGDS, PGFS, PGIS, and thromboxane A synthase (TXAS). ...
Prostaglandins (PGs) belong to a subclass of eicosanoids and are classified based on the structures of the cyclopentane ring and thei
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
Zelenay S, et al. Cell 2015. PMID 26343581 Free PMC article.
Here, we show that the growth of tumors formed by mutant Braf(V600E) mouse melanoma cells in an immunocompetent host requires their production of prostaglandin E2, which suppresses immunity and fuels tumor-promoting inflammation. Genetic ablation of cyclooxygenases (COX) or prostaglandin E synthases in Braf(V600E) mouse melanoma cells, as well as in Nras(G12D) melanoma or in breast or colorectal cancer cells, renders them susceptible to immune control and provokes a shift in the tumor inflammatory profile toward classic anti-cancer immune pathways. ...
Here, we show that the growth of tumors formed by mutant Braf(V600E) mouse melanoma cells in an immunocompetent host requires their producti …
Cyclooxygenase pathways
Korbecki J, et al. Acta Biochim Pol 2014 - Review. PMID 25343148 Free article.
Interaction mechanisms between the receptors for the relevant compounds are presented, in particular with regard to the cooperation between a thromboxane A₂ and prostaglandin I₂ receptors. ...Special attention is given to the significance of 15-deoxy-Δ(12,14)-prostaglandin J₂ in the regulation of the synthesis of prostanoids and its role as an anti-inflammatory agent. ...
Interaction mechanisms between the receptors for the relevant compounds are presented, in particular with regard to the cooperation between …
Endometrial prostaglandin synthases, ovarian steroids, and oxytocin receptors in mares with oxytocin-induced luteal maintenance.
Rebordão MR, et al. Theriogenology 2017. PMID 27773348
Also, endometrial expression of prostaglandin endoperoxide synthase 2 (PTGS2), prostaglandin F(2)α, E(2) and I(2) synthases (AKR1C3, PTGES, and PTGIS), oxytocin receptor (OXTR), progesterone receptor (PGR), and estrogen receptors 1 (ESR1) and 2 (ESR2) were assessed in mares experiencing luteal maintenance 2 weeks after chronic exogenous OXT administration. ...
Also, endometrial expression of prostaglandin endoperoxide synthase 2 (PTGS2), prostaglandin F(2)α, E(2) and I(2) synthases (A …
Studies on Prostaglandin-Endoperoxide Synthase 1: Lower Levels in Schizophrenia and After Treatment with Antipsychotic Drugs in Conjunction with Aspirin.
Dean B, et al. Int J Neuropsychopharmacol 2018. PMID 30052978 Free PMC article.
BACKGROUND: Antipsychotic drugs plus aspirin (acetylsalicylic acid), which targets prostaglandin-endoperoxide synthase 1 (PTGS1: COX1), improved therapeutic outcomes when treating schizophrenia. ...
BACKGROUND: Antipsychotic drugs plus aspirin (acetylsalicylic acid), which targets prostaglandin-endoperoxide synthase 1 (PTGS1: COX1 …
Paracetamol in fever in critically ill patients-an update
Chiumello D, et al. J Crit Care 2017 - Review. PMID 27992852
Its antipyretic effect occurs because it inhibits cyclooxygenase-3 and the prostaglandin synthesis, within the central nervous system, resetting the hypothalamic heat-regulation center. ...
Its antipyretic effect occurs because it inhibits cyclooxygenase-3 and the prostaglandin synthesis, within the central nervous system …
Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs
Gabbs M, et al. Adv Nutr 2015 - Review. PMID 26374175 Free PMC article.
They are formed via cyclooxygenase, lipoxygenase, and cytochrome P450 pathways, resulting in the formation of prostaglandins, thromboxanes, mono-, di-, and tri-hydroxy fatty acids (FAs), epoxy FAs, lipoxins, eoxins, hepoxilins, resolvins, protectins (also called neuroprotectins in the brain), and maresins. ...
They are formed via cyclooxygenase, lipoxygenase, and cytochrome P450 pathways, resulting in the formation of prostaglandins, thrombo …
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