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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 15
1976 23
1977 22
1978 27
1979 29
1980 44
1981 44
1982 34
1983 60
1984 61
1985 56
1986 51
1987 47
1988 38
1989 66
1990 59
1991 55
1992 60
1993 73
1994 85
1995 134
1996 137
1997 214
1998 198
1999 295
2000 300
2001 358
2002 441
2003 453
2004 543
2005 625
2006 623
2007 583
2008 541
2009 549
2010 496
2011 469
2012 453
2013 397
2014 406
2015 342
2016 304
2017 262
2018 278
2019 125
2020 2
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9,539 results
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Page 1
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
Zelenay S, et al. Cell 2015. PMID 26343581 Free PMC article.
Here, we show that the growth of tumors formed by mutant Braf(V600E) mouse melanoma cells in an immunocompetent host requires their production of prostaglandin E2, which suppresses immunity and fuels tumor-promoting inflammation. Genetic ablation of cyclooxygenases (COX) or prostaglandin E synthases in Braf(V600E) mouse melanoma cells, as well as in Nras(G12D) melanoma or in breast or colorectal cancer cells, renders them susceptible to immune control and provokes a shift in the tumor inflammatory profile toward classic anti-cancer immune pathways. ...
Here, we show that the growth of tumors formed by mutant Braf(V600E) mouse melanoma cells in an immunocompetent host requires their producti …
Cyclooxygenase enzymes: regulation and function
Fitzpatrick FA. Curr Pharm Des 2004 - Review. PMID 14965321
The cyclooxygenase isoenzymes, COX-1 and COX-2, catalyze the formation of prostaglandins, thromboxane, and levuloglandins. The prostaglandins are autocoid mediators that affect virtually all known physiological and pathological processes via their reversible interaction with G-protein coupled membrane receptors. ...This review discusses: 1) how two separate catalytic processes in COX - peroxidase and prostaglandin synthase - act in an integrated fashion manner to generate prostaglandins; 2) why irreversible inactivation of COX is important constitutively and pharmacologically; 3) how cells have managed to use two closely related, almost identical enzymes in ways that discriminate their physiological versus pathological roles; 4) how investigators have used these advances to formulate and test medically important uses for old drugs (i.e. aspirin) and create new ones that still seek to achieve Hoffman's original goal....
The cyclooxygenase isoenzymes, COX-1 and COX-2, catalyze the formation of prostaglandins, thromboxane, and levuloglandins. The pro
Cyclooxygenase pathways
Korbecki J, et al. Acta Biochim Pol 2014 - Review. PMID 25343148 Free article.
Interaction mechanisms between the receptors for the relevant compounds are presented, in particular with regard to the cooperation between a thromboxane A₂ and prostaglandin I₂ receptors. ...Special attention is given to the significance of 15-deoxy-Δ(12,14)-prostaglandin J₂ in the regulation of the synthesis of prostanoids and its role as an anti-inflammatory agent. ...
Interaction mechanisms between the receptors for the relevant compounds are presented, in particular with regard to the cooperation between …
Cyclooxygenases: structural, cellular, and molecular biology
Smith WL, et al. Annu Rev Biochem 2000 - Review. PMID 10966456
The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin synthesis. ...
The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also cyclooxygenases-1 and 2, COX-1 and COX-2) c …
Distinct influence of COX-1 and COX-2 on neuroinflammatory response and associated cognitive deficits during high altitude hypoxia
Chauhan G, et al. Neuropharmacology 2019. PMID 30476507
Previous studies have shown arachidonic acid (AA) metabolism due to cyclooxygenase (COX) activity before clinical manifestations in many diseases. ...In the present study, AA metabolism via the COX pathway was investigated in Sprague Dawley rats after 0, 1, 3, and 7 days of HH exposure. ...
Previous studies have shown arachidonic acid (AA) metabolism due to cyclooxygenase (COX) activity before clinical manifestations in m …
Immunopresence and functional activity of prostaglandin-endoperoxide synthases and nitric oxide synthases in bovine corpora lutea during diestrus.
Zerani M, et al. Folia Morphol (Warsz) 2013. PMID 23749709 Free article.
The aim of this study was to evaluate the occurrence and the activity of prostaglandin-endoperoxide synthase 1 (PTGS1), PTGS2, and endothelial, neuronal, and inducible nitric oxide synthase (e-, n-, and iNOS) in early, mid, late, and regressive corpora lutea (CL) of bovines during diestrus. ...
The aim of this study was to evaluate the occurrence and the activity of prostaglandin-endoperoxide synthase 1 (PTGS1), PTGS2, …
Cyclooxygenases 1 and 2
Vane JR, et al. Annu Rev Pharmacol Toxicol 1998 - Review. PMID 9597150
Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. ...
Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arac …
9,539 results
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