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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 2
1948 1
1951 1
1952 2
1953 5
1954 2
1955 3
1956 13
1957 4
1958 8
1959 9
1960 22
1961 12
1962 14
1963 30
1964 33
1965 96
1966 208
1967 606
1968 719
1969 940
1970 1355
1971 2039
1972 2917
1973 3179
1974 4357
1975 4001
1976 3718
1977 2444
1978 2046
1979 2430
1980 2462
1981 1942
1982 1794
1983 1746
1984 1883
1985 1698
1986 1739
1987 1713
1988 1603
1989 1609
1990 1906
1991 1771
1992 1766
1993 2071
1994 3166
1995 3763
1996 4116
1997 4070
1998 4749
1999 5048
2000 6453
2001 8182
2002 8620
2003 8771
2004 9940
2005 10117
2006 10064
2007 10523
2008 10740
2009 11462
2010 11721
2011 12967
2012 12778
2013 13714
2014 12222
2015 12136
2016 12161
2017 11938
2018 10111
2019 4355
2020 63
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269,434 results
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Page 1
A brave new world of RNA-binding proteins.
Hentze MW, et al. Nat Rev Mol Cell Biol 2018 - Review. PMID 29339797
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one or multiple globular RNA-binding domains (RBDs) and change the fate or function of the bound RNAs. ...In this Review, we discuss these new RBPs and the emerging understanding of their unexpected modes of RNA binding, which can be mediated by intrinsically disordered regions, protein-protein interaction interfaces and enzymatic cores, among others. ...
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one or multiple globular RNA-binding do …
Aspects of Drug-Protein Binding and Methods of Analyzing the Phenomenon.
Wanat K, et al. Curr Pharm Des 2018 - Review. PMID 30088445
Nowadays, increasing attention is paid to the computational methods and molecular modeling which are convenient tools to estimate protein binding affinity based on the physicochemical properties of compounds. To gain a broader overview, the study also examines the protein binding ability and pharmacotherapy of drugs against a range of substrates such as plasma, skin, tissue and human milk....
Nowadays, increasing attention is paid to the computational methods and molecular modeling which are convenient tools to estimate protein
Modeling protein-DNA binding via high-throughput in vitro technologies.
Orenstein Y and Shamir R. Brief Funct Genomics 2017. PMID 27497616 Free PMC article.
Protein-DNA binding plays a central role in gene regulation and by that in all processes in the living cell. Novel experimental and computational approaches facilitate better understanding of protein-DNA binding preferences via high-throughput measurement of protein binding to a large number of DNA sequences and inference of binding models from them. Here we review the state of the art in measuring protein-DNA binding in vitro, emphasizing the advantages and limitations of different technologies. ...
Protein-DNA binding plays a central role in gene regulation and by that in all processes in the living cell. Novel experimenta
Seventy-Five Years of Research on Protein Binding.
Dalhoff A. Antimicrob Agents Chemother 2018 - Review. PMID 29158276 Free PMC article.
This review summarizes evidence that the impact of protein binding of the activity of antibiotics is multifaceted and more complex than indicated by the numerical value of protein binding alone. A plethora of studies has proven that protein binding of antibiotics matters, as the free fraction only is antibacterially active and governs pharmacokinetics. ...
This review summarizes evidence that the impact of protein binding of the activity of antibiotics is multifaceted and more com …
Approaches to measure protein binding of enzymatically unstable compounds in plasma.
Ye Z and Gao H. Bioanalysis 2018. PMID 29633861
Protein binding of the compounds in BNPP-treated rat plasma was measured using equilibrium dialysis or ultrafiltration. CONCLUSION: PPB measurement of unstable compounds was improved by using enzyme inhibitor to stabilize the compounds in plasma during the assay. The effect of BNPP concentration on drug-protein binding appeared to be compound dependent. Given the compound's nonspecific binding to the assay device can be accounted for in the unbound fraction measurement, ultrafiltration can be a viable alternative or complementary approach for PPB assay of unstable compounds while minimizing the potential impact of enzyme inhibitor on drug-protein binding....
Protein binding of the compounds in BNPP-treated rat plasma was measured using equilibrium dialysis or ultrafiltration. CONCLU
Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology.
Abrusán G and Marsh JA. Cell Rep 2018. PMID 29562182 Free PMC article.
It has been suggested that the evolution of protein complexes is significantly influenced by stochastic, non-adaptive processes. Using ligand binding as a proxy of function, we show that the structure of ligand-binding sites significantly influences the evolution of protein complexes. ...
It has been suggested that the evolution of protein complexes is significantly influenced by stochastic, non-adaptive processes. Usin …
Affinity chromatography: general methods
Urh M, et al. Methods Enzymol 2009 - Review. PMID 19892186
However, in some cases new affinity chromatographic material may need to be developed by coupling the ligand onto the matrix such that the ligand retains specific binding affinity for the molecule of interest. ...
However, in some cases new affinity chromatographic material may need to be developed by coupling the ligand onto the matrix such that the l …
Protein Domain Mimics as Modulators of Protein-Protein Interactions.
Sawyer N, et al. Acc Chem Res 2017 - Review. PMID 28561588 Free PMC article.
Protein-protein interactions (PPIs) are ubiquitous in biological systems and often misregulated in disease. As such, specific PPI modulators are desirable to unravel complex PPI pathways and expand the number of druggable targets available for therapeutic intervention. ...In mimicking a main-chain hydrogen bond, the HBS approach stabilizes the α-helical conformation while leaving all helical faces available for functionalization to tune binding affinity and specificity. ...
Protein-protein interactions (PPIs) are ubiquitous in biological systems and often misregulated in disease. As such, specific
Protein folding and binding can emerge as evolutionary spandrels through structural coupling.
Manhart M and Morozov AV. Proc Natl Acad Sci U S A 2015. PMID 25624494 Free PMC article.
Several recent studies have shown the importance of folding stability in constraining protein evolution. Here we investigate how structural coupling between folding and binding--the fact that most proteins can only bind their targets when folded--gives rise to an evolutionary coupling between the traits of folding stability and binding strength. ...In particular, proteins can evolve strong binding interactions that have no functional role but merely serve to stabilize the protein if its misfolding is deleterious. ...
Several recent studies have shown the importance of folding stability in constraining protein evolution. Here we investigate how stru …
The Art of Compiling Protein Binding Site Ensembles.
Bietz S, et al. Mol Inform 2016 - Review. PMID 27870245
In this paper, we summarize our research activities towards an automated processing pipeline from raw PDB data towards ready-to-use protein binding site ensembles. ...For the first time, we are able to process the whole PDB in order to create a large collection of protein binding site ensembles. ...
In this paper, we summarize our research activities towards an automated processing pipeline from raw PDB data towards ready-to-use prote
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