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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1994 13
1995 29
1996 49
1997 20
1998 19
1999 20
2000 28
2001 56
2002 91
2003 156
2004 337
2005 390
2006 388
2007 381
2008 424
2009 459
2010 490
2011 444
2012 454
2013 408
2014 419
2015 462
2016 409
2017 412
2018 306
2019 136
2020 0
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6,220 results
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Page 1
Cross-Linking/Mass Spectrometry for Studying Protein Structures and Protein-Protein Interactions: Where Are We Now and Where Should We Go from Here?
Sinz A. Angew Chem Int Ed Engl 2018 - Review. PMID 29334167
In this Minireview, I will focus on the cross-linking/MS strategy. This method not only delivers tertiary structural information on proteins, but is also increasingly being used to decipher protein interaction networks, both in vitro and in vivo. Cross-linking/MS is currently one of the most promising MS-based approaches to derive structural information on very large and transient protein assemblies and intrinsically disordered proteins....
In this Minireview, I will focus on the cross-linking/MS strategy. This method not only delivers tertiary structural information
An Overview of Current Methods to Confirm Protein-Protein Interactions.
Miura K. Protein Pept Lett 2018 - Review. PMID 30129399 Free PMC article.
BACKGROUND: The research field of protein-protein interactions is interdisciplinary and specialized field that spans all aspects of biology, physics and chemistry. ...RESULTS: It is often necessary to integrate, combine and validate multiple results from various methods to understand protein-protein interactions in detail. ...
BACKGROUND: The research field of protein-protein interactions is interdisciplinary and specialized field that s …
The impact of protein interaction networks' characteristics on computational complex detection methods.
Liu X, et al. J Theor Biol 2018. PMID 29217484
Protein complexes of physically interacting proteins play an important role in organizing various biological processes in the cell. ...We hope our study will not only help recognize the relations between characteristics of protein interaction networks and computational complex detection methods, but also provide valuable insight to improve the performance in protein complex detection area....
Protein complexes of physically interacting proteins play an important role in organizing various biological processes
Straightforward Protein-Protein Interaction Interface Mapping via Random Mutagenesis and Mammalian Protein Protein Interaction Trap (MAPPIT).
Vyncke L, et al. Int J Mol Sci 2019 - Review. PMID 31027327 Free PMC article.
The MAPPIT (mammalian protein protein interaction trap) method allows high-throughput detection of protein interactions by very simple co-transfection of three plasmids in HEK293T cells, followed by a luciferase readout. MAPPIT detects a large percentage of all protein interactions, including those requiring posttranslational modifications and endogenous or exogenous ligands. ...
The MAPPIT (mammalian protein protein interaction trap) method allows high-throughput detection of protein in
Advances in the development of human protein microarrays.
Duarte JG and Blackburn JM. Expert Rev Proteomics 2017 - Review. PMID 28644690
High-content protein microarrays in principle enable the functional interrogation of the human proteome in a broad range of applications, including biomarker discovery, profiling of immune responses, identification of enzyme substrates, and quantifying protein-small molecule, protein-protein and protein-DNA/RNA interactions. ...Full-length protein arrays offer advantages in biomarker discovery profiling applications, although care is required in ensuring that the protein production and array fabrication methodology is compatible with the required downstream functionality....
High-content protein microarrays in principle enable the functional interrogation of the human proteome in a bro …
PPInS: a repository of protein-protein interaction sitesbase.
Kumar V, et al. Sci Rep 2018. PMID 30127348 Free PMC article.
Protein-Protein Interaction Sitesbase (PPInS), a high-performance database of protein-protein interacting interfaces, is presented. The atomic level information of the molecular interaction happening amongst various protein chains in protein-protein complexes (as reported in the Protein Data Bank [PDB]) together with their evolutionary information in Structural Classification of Proteins (SCOPe release 2.06), is made available in PPInS. ...
Protein-Protein Interaction Sitesbase (PPInS), a high-performance database of protein-protein interact
Application of Machine Learning Approaches for Protein-protein Interactions Prediction.
Zhang M, et al. Med Chem 2017 - Review. PMID 28530547
BACKGROUND: Proteomics endeavors to study the structures, functions and interactions of proteins. Information of the protein-protein interactions (PPIs) helps to improve our knowledge of the functions and the 3D structures of proteins. ...CONCLUSION: This review presents the application of machine learning approaches in predicting PPI. Many examples of success in identification and prediction in the area of PPI prediction have been discussed, and the PPIs research is still in progress....
BACKGROUND: Proteomics endeavors to study the structures, functions and interactions of proteins. Information of the protei
BioPlex Display: An Interactive Suite for Large-Scale AP-MS Protein-Protein Interaction Data.
Schweppe DK, et al. J Proteome Res 2018. PMID 29054129 Free PMC article.
Knowledge of protein-protein interaction (PPI) networks has become a principle interest of many groups within the field of proteomics. ...BioPlex Display enables rapid acquisition of data from BioPlex and development of hypotheses based on protein interactions....
Knowledge of protein-protein interaction (PPI) networks has become a principle interest of many groups within th …
Targeting protein-protein interactions for drug discovery.
Fry DC. Methods Mol Biol 2015. PMID 25859945
Protein-protein interactions are associated with key activities and pathways in the cell, and in that regard are promising targets for drug discovery. ...Nevertheless, success stories have begun to steadily appear in this field. These experiences are starting to provide general strategies and tools to help overcome the problems inherent in pursuing protein-protein interaction targets. ...
Protein-protein interactions are associated with key activities and pathways in the cell, and in that reg
Protein-protein interaction specificity is captured by contact preferences and interface composition.
Nadalin F and Carbone A. Bioinformatics 2018. PMID 29028884 Free PMC article.
MOTIVATION: Large-scale computational docking will be increasingly used in future years to discriminate protein-protein interactions at the residue resolution. Complete cross-docking experiments make in silico reconstruction of protein-protein interaction networks a feasible goal. They ask for efficient and accurate screening of the millions structural conformations issued by the calculations. ...
MOTIVATION: Large-scale computational docking will be increasingly used in future years to discriminate protein-prot
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