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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 2
1982 1
1983 2
1987 1
1991 1
1993 1
1994 3
1995 3
1996 6
1997 5
1998 361
1999 1518
2000 2129
2001 2209
2002 2285
2003 2310
2004 2348
2005 2327
2006 2290
2007 2226
2008 2356
2009 2422
2010 2396
2011 2456
2012 2328
2013 2033
2014 1896
2015 1843
2016 1741
2017 1647
2018 1444
2019 630
2020 3
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39,005 results
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Page 1
Flower isoforms promote competitive growth in cancer.
Madan E, et al. Nature 2019. PMID 31341286
It is unknown whether a similar mechanism of cell-fitness comparison is present in humans. Here we show that two human Flower isoforms (hFWE1 and hFWE3) behave as Flower-Lose proteins, whereas the other two isoforms (hFWE2 and hFWE4) behave as Flower-Win proteins. The latter give cells a competitive advantage over cells expressing Lose isoforms, but Lose-expressing cells are not eliminated if their neighbours express similar levels of Lose isoforms; these proteins therefore act as fitness fingerprints. ...
It is unknown whether a similar mechanism of cell-fitness comparison is present in humans. Here we show that two human Flower …
AMP-activated protein kinase: the current landscape for drug development.
Steinberg GR and Carling D. Nat Rev Drug Discov 2019 - Review. PMID 30867601 Free article.
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy homeostasis, many exciting insights into its structure, regulation and physiological roles have been revealed. ...
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy homeostasis, many exciting insights into …
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.
Gandal MJ, et al. Science 2018. PMID 30545856 Free PMC article.
More than 25% of the transcriptome exhibits differential splicing or expression, with isoform-level changes capturing the largest disease effects and genetic enrichments. Coexpression networks isolate disease-specific neuronal alterations, as well as microglial, astrocyte, and interferon-response modules defining previously unidentified neural-immune mechanisms. ...
More than 25% of the transcriptome exhibits differential splicing or expression, with isoform-level changes capturing the largest dis …
Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli C, et al. Nucleic Acids Res 2019. PMID 30590745 Free PMC article.
Using reporter assays and 3'UTR swapping experiments, we have identified the role of alternative 3'UTRs and mRNA transport in differential localization of alternative CDC42 protein isoforms. ...Our analysis points to usage of alternative 3'UTR isoforms as a novel mechanism to provide for differential localization of functionally diverse alternative protein isoforms....
Using reporter assays and 3'UTR swapping experiments, we have identified the role of alternative 3'UTRs and mRNA transport in differential l …
MITF-the first 25 years
Goding CR and Arnheiter H. Genes Dev 2019 - Review. PMID 31123060 Free PMC article.
In the 25 yr since the gene encoding the microphthalmia-associated transcription factor (MITF) was first isolated, MITF has emerged as a key coordinator of many aspects of melanocyte and melanoma biology. ...What marks MITF as being remarkable among its peers is the sheer range of biological processes that it appears to coordinate. ...
In the 25 yr since the gene encoding the microphthalmia-associated transcription factor (MITF) was first isolated, MITF has emerged a …
Single-dose CRISPR-Cas9 therapy extends lifespan of mice with Hutchinson-Gilford progeria syndrome
Beyret E, et al. Nat Med 2019. PMID 30778240 Free PMC article.
Hutchinson-Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated aging. The major underlying genetic cause is a substitution mutation in the gene coding for lamin A, causing the production of a toxic isoform called progerin. ...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated ag …
ApoE attenuates unresolvable inflammation by complex formation with activated C1q
Yin C, et al. Nat Med 2019. PMID 30692699 Free PMC article.
All human ApoE isoforms attenuated CCC activity via high-affinity binding to the activated CCC-initiating C1q protein (K(D)~140-580 pM) in vitro, and C1q-ApoE complexes emerged as markers for ongoing complement activity of diseased ChPs, Aβ plaques, and atherosclerosis in vivo. ...Thus, ApoE is a direct checkpoint inhibitor of unresolvable inflammation, and reducing C5 attenuates disease burden....
All human ApoE isoforms attenuated CCC activity via high-affinity binding to the activated CCC-initiating C1q protein (K(D)~14 …
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Tzelepis K, et al. Nat Commun 2018. PMID 30568163 Free PMC article.
RNA-seq analysis demonstrates that SRPK1 inhibition leads to altered isoform levels of many genes including several with established roles in leukemogenesis such as MYB, BRD4 and MED24. We focus on BRD4 as its main isoforms have distinct molecular properties and find that SRPK1 inhibition produces a significant switch from the short to the long isoform at the mRNA and protein levels. ...
RNA-seq analysis demonstrates that SRPK1 inhibition leads to altered isoform levels of many genes including several with established …
Identification of isoforms of calyculin A-sensitive protein phosphatases which suppress full-type hyperactivation in bull ejaculated spermatozoa.
Arai Y, et al. Theriogenology 2019. PMID 30798082
In bull spermatozoa, extracellular Ca(2+)-dependent full-type hyperactivation, which is characterized by the asymmetrical beating in whole parts of the middle/principal pieces, is suppressed by calyculin A-sensitive protein phosphatases. ...Moreover, the immunodetection of protein phosphatase isoforms showed sperm connecting piece and flagellum included protein phosphatases 1α and 1γ, but did not do the other isoforms. ...
In bull spermatozoa, extracellular Ca(2+)-dependent full-type hyperactivation, which is characterized by the asymmetrical beating in …
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