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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 2
1968 1
1969 9
1970 12
1971 18
1972 15
1973 10
1974 22
1975 15
1976 15
1977 23
1978 22
1979 15
1980 20
1981 24
1982 42
1983 29
1984 46
1985 47
1986 61
1987 44
1988 59
1989 57
1990 105
1991 175
1992 223
1993 271
1994 335
1995 438
1996 460
1997 528
1998 609
1999 849
2000 1162
2001 1280
2002 1244
2003 1277
2004 1096
2005 738
2006 753
2007 737
2008 793
2009 773
2010 822
2011 850
2012 865
2013 719
2014 645
2015 662
2016 560
2017 575
2018 470
2019 198
2020 7
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19,380 results
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Page 1
The Opportunities and Challenges of Peroxisome Proliferator-Activated Receptors Ligands in Clinical Drug Discovery and Development
Hong F, et al. Int J Mol Sci 2018 - Review. PMID 30060458 Free PMC article.
The three PPAR isoforms (α, β/δ and γ) have emerged as integrators of glucose and lipid metabolic signaling networks. Typically, PPARα is activated by fibrates, which are commonly used therapeutic agents in the treatment of dyslipidemia. ...
The three PPAR isoforms (α, β/δ and γ) have emerged as integrators of glucose and lipid metabolic signaling networks. Typically, PPAR …
[Aspartate aminotransferase--key enzyme in the human systemic metabolism]
Otto-Ślusarczyk D, et al. Postepy Hig Med Dosw (Online) 2016 - Review. PMID 27117097 Polish. Free article.
Both isoforms are homodimers containing highly conservative regions responsible for catalytic properties of enzyme. The common feature of all aspartate aminotransfeses is Lys - 259 residue covalent binding with prosthetic group - pyridoxal phosphate. ...Aspartate aminotransferase is a part of the malate-aspartate shuttle in the myocardium, is involved in gluconeogenesis in the liver and kidney, glyceroneogenesis in the adipose tissue, and synthesis of neurotransmitters and neuro-glial pathway in the brain. ...
Both isoforms are homodimers containing highly conservative regions responsible for catalytic properties of enzyme. The common featur …
Laminin: loss-of-function studies
Yao Y. Cell Mol Life Sci 2017 - Review. PMID 27696112
Phospholipase A2 Isoforms as Novel Targets for Prevention and Treatment of Inflammatory and Oncologic Diseases.
Yarla NS, et al. Curr Drug Targets 2016 - Review. PMID 26212262
Each isoform of PLA2s is different in its chemical structure and physiological functions. sPLA2s (Groups IIA, V and X) are well characterized as proinflammatory mediating enzymes but their role in cancer is controversial. ...The role of iPLA2 in inflammation and cancer is limited. Lipoprotein associated PLA2 (Group VIIA PLA2), a PAF-AH isoform, has key role in atherosclerosis. ...
Each isoform of PLA2s is different in its chemical structure and physiological functions. sPLA2s (Groups IIA, V and X) are wel …
Analysis of protein isoforms: can we do it better?
Stastna M and Van Eyk JE. Proteomics 2012 - Review. PMID 22888084 Free PMC article.
Thus, there is a need for efficient and, importantly, accurate methods to distinguish and quantify specific protein isoforms. ...Recently, novel approaches have been explored and developed that can possess the accuracy and reliability important for protein isoform differentiation and isoform-specific peptide targeting. ...
Thus, there is a need for efficient and, importantly, accurate methods to distinguish and quantify specific protein isoform
Detection of protein phosphorylation and charge isoforms using vertical one-dimensional isoelectric focusing gels.
Anderson JC and Peck SC. Methods Mol Biol 2014. PMID 24908118
However, many protein modifications alter the isoelectric point (pI) of a protein. Therefore, we developed a denaturing, one-dimensional isoelectric focusing (IEF) procedure that separates proteins based on their pI to resolve different isoforms, allowing a relatively simple strategy for detecting changes in protein modifications. ...This combination of techniques provides the means of interrogating the number and stoichiometry of isoforms from total protein extracts without a priori knowledge of which modification may occur....
However, many protein modifications alter the isoelectric point (pI) of a protein. Therefore, we developed a denaturing …
Monolith disk chromatography separates PEGylated protein positional isoforms within minutes at low pressure.
Isakari Y, et al. Biotechnol J 2016. PMID 26626923
The method was optimized for separation of randomly PEGylated protein (lysozyme) isoforms based on the number of resolved peaks, peak resolution, analysis time and pressure drop. In order to increase the retention of mono- and di-PEGylated protein isomers the mobile phase was decreased to pH 4.5, where a large number of mono- and di-PEGylated isomers were resolved within a few minutes. ...
The method was optimized for separation of randomly PEGylated protein (lysozyme) isoforms based on the number of resolved peak …
Inhibitory influence of natural flavonoids on human protein kinase CK2 isoforms: effect of the regulatory subunit.
Baier A, et al. Mol Cell Biochem 2018. PMID 29188536 Free PMC article.
CK2 is a pleiotropic, constitutively active protein kinase responsible for the phosphorylation of more than 300 physiological substrates. Typically, this enzyme is found in tetrameric form consisting of two regulatory subunits CK2β and two catalytic subunits CK2α or CK2α'. ...
CK2 is a pleiotropic, constitutively active protein kinase responsible for the phosphorylation of more than 300 physiological …
PEPPI: a peptidomic database of human protein isoforms for proteomics experiments.
Zhou A, et al. BMC Bioinformatics 2010. PMID 20946618 Free PMC article.
BACKGROUND: Protein isoform generation, which may derive from alternative splicing, genetic polymorphism, and posttranslational modification, is an essential source of achieving molecular diversity by eukaryotic cells. ...However, due to limited annotation and poor coverage of protein isoforms in proteomics databases, high throughput protein isoform identifications, particularly those arising from alternative splicing and genetic polymorphism, have not been possible. ...
BACKGROUND: Protein isoform generation, which may derive from alternative splicing, genetic polymorphism, and posttranslationa …
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