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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1971 3
1974 2
1975 2
1977 52
1978 75
1979 80
1980 108
1981 107
1982 144
1983 192
1984 164
1985 175
1986 183
1987 237
1988 230
1989 258
1990 350
1991 415
1992 450
1993 466
1994 488
1995 596
1996 595
1997 699
1998 1004
1999 1618
2000 2051
2001 2039
2002 2048
2003 2028
2004 1993
2005 1624
2006 1761
2007 1714
2008 1735
2009 1903
2010 1874
2011 1860
2012 1755
2013 1594
2014 1376
2015 1354
2016 1226
2017 1207
2018 920
2019 379
2020 1
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37,925 results
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Page 1
Alternative Splicing May Not Be the Key to Proteome Complexity
Tress ML, et al. Trends Biochem Sci 2017 - Review. PMID 27712956 Free PMC article.
Alternative splicing is commonly believed to be a major source of cellular protein diversity. However, although many thousands of alternatively spliced transcripts are routinely detected in RNA-seq studies, reliable large-scale mass spectrometry-based proteomics analyses identify only a small fraction of annotated alternative isoforms. The clearest finding from proteomics experiments is that most human genes have a single main protein isoform, while those alternative isoforms that are identified tend to be the most biologically plausible: those with the most cross-species conservation and those that do not compromise functional domains. ...
Alternative splicing is commonly believed to be a major source of cellular protein diversity. However, although many thousands of alt …
The Functional Impact of Alternative Splicing in Cancer
Climente-González H, et al. Cell Rep 2017. PMID 28854369 Free article.
This analysis revealed that a subset of alternative splicing changes affect protein domain families that are frequently mutated in tumors and potentially disrupt protein-protein interactions in cancer-related pathways. ...
This analysis revealed that a subset of alternative splicing changes affect protein domain families that are frequently mutated in tu …
Ribosome Footprint Profiling of Translation throughout the Genome
Ingolia NT. Cell 2016. PMID 27015305 Free PMC article.
This Primer looks at important experimental and analytical concerns for executing ribosome profiling experiments and surveys recent examples where the approach was developed to explore protein biogenesis and homeostasis....
This Primer looks at important experimental and analytical concerns for executing ribosome profiling experiments and surveys recent examples …
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li B and Dewey CN. BMC Bioinformatics 2011. PMID 21816040 Free PMC article.
A key challenge in transcript quantification from RNA-Seq data is the handling of reads that map to multiple genes or isoforms. This issue is particularly important for quantification with de novo transcriptome assemblies in the absence of sequenced genomes, as it is difficult to determine which transcripts are isoforms of the same gene. ...
A key challenge in transcript quantification from RNA-Seq data is the handling of reads that map to multiple genes or isoforms. This …
Alternative splicing isoforms in health and disease.
Kim HK, et al. Pflugers Arch 2018 - Review. PMID 29536164
Alternative splicing (AS) of protein-coding messenger RNAs is an essential regulatory mechanism in eukaryotic gene expression that controls the proper function of proteins. ...Accumulated data highlight the importance of alternatively spliced isoforms in various diseases, including neurodegenerative disorders, cancer, immune and infectious diseases, cardiovascular diseases, and metabolic conditions. ...
Alternative splicing (AS) of protein-coding messenger RNAs is an essential regulatory mechanism in eukaryotic gene expression that co …
Proteogenomics: concepts, applications and computational strategies
Nesvizhskii AI. Nat Methods 2014 - Review. PMID 25357241 Free PMC article.
In this approach, customized protein sequence databases generated using genomic and transcriptomic information are used to help identify novel peptides (not present in reference protein sequence databases) from mass spectrometry-based proteomic data; in turn, the proteomic data can be used to provide protein-level evidence of gene expression and to help refine gene models. ...Here I review the current state of proteogenomic methods and applications, including computational strategies for building and using customized protein sequence databases. ...
In this approach, customized protein sequence databases generated using genomic and transcriptomic information are used to help ident …
Intron retention as a component of regulated gene expression programs
Jacob AG and Smith CWJ. Hum Genet 2017 - Review. PMID 28391524 Free PMC article.
Furthermore, these studies revealed various ways in which intron retention regulates protein isoform production, RNA stability and translation efficiency, and rapid induction of expression via post-transcriptional splicing of retained introns. ...
Furthermore, these studies revealed various ways in which intron retention regulates protein isoform production, RNA stability and tr …
Ribosome profiling: new views of translation, from single codons to genome scale
Ingolia NT. Nat Rev Genet 2014 - Review. PMID 24468696
However, neither approach provides information on protein synthesis, which is the true end point of gene expression. Ribosome profiling is an emerging technique that uses deep sequencing to monitor in vivo translation. Studies using ribosome profiling have already provided new insights into the identity and the amount of proteins that are produced by cells, as well as detailed views into the mechanism of protein synthesis itself....
However, neither approach provides information on protein synthesis, which is the true end point of gene expression. Ribosome profili …
Posttranslational modifications of neuroligins regulate neuronal and glial signaling
Jeong J, et al. Curr Opin Neurobiol 2017 - Review. PMID 28577430 Free PMC article.
This review covers the dynamic regulation of neuroligin isoforms, focusing on posttranslational events including phosphorylation, glycosylation and activity-dependent cleavage. There is a growing literature on how phosphorylation confers an isoform-specific level of modulation affecting a variety of protein interactions. ...
This review covers the dynamic regulation of neuroligin isoforms, focusing on posttranslational events including phosphorylation, gly …
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