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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1964 3
1965 34
1966 67
1967 72
1968 134
1969 120
1970 148
1971 247
1972 214
1973 354
1974 484
1975 544
1976 607
1977 662
1978 623
1979 631
1980 564
1981 526
1982 571
1983 718
1984 755
1985 737
1986 819
1987 846
1988 805
1989 837
1990 982
1991 1067
1992 1144
1993 1240
1994 1441
1995 1686
1996 1849
1997 2020
1998 2486
1999 3582
2000 4407
2001 4559
2002 4506
2003 4316
2004 4132
2005 3124
2006 3235
2007 3240
2008 3131
2009 3271
2010 3183
2011 3249
2012 3057
2013 2747
2014 2461
2015 2338
2016 2033
2017 1919
2018 1613
2019 676
2020 14
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85,007 results
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Page 1
Function of alternative splicing
Kelemen O, et al. Gene 2013 - Review. PMID 22909801 Free PMC article.
The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing changes proteins encoded by mRNAs, which has profound functional effects. Experimental analysis of these protein isoforms showed that alternative splicing regulates binding between proteins, between proteins and nucleic acids as well as between proteins and membranes. ...
The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing ch …
The Functional Impact of Alternative Splicing in Cancer
Climente-González H, et al. Cell Rep 2017. PMID 28854369 Free article.
This analysis revealed that a subset of alternative splicing changes affect protein domain families that are frequently mutated in tumors and potentially disrupt protein-protein interactions in cancer-related pathways. ...
This analysis revealed that a subset of alternative splicing changes affect protein domain families that are frequently mutated in tu …
Poliovirus Receptor: More than a simple viral receptor
Bowers JR, et al. Virus Res 2017 - Review. PMID 28870470 Free PMC article.
The human poliovirus receptor (PVR) is a cell surface protein with a multitude of functions in human biology. PVR was initially identified as the receptor for the human poliovirus and recent discoveries have given a greater insight into both its morphology and its function. ...PVR is an important cell adhesion protein and is involved in the transendothelial migration of leukocytes. Through its interactions with CD226 and TIGIT, transmembrane proteins found on leukocytes, PVR is a key regulator of the cell-mediated immune response. ...
The human poliovirus receptor (PVR) is a cell surface protein with a multitude of functions in human biology. PVR was initiall …
MLL5 (KMT2E): structure, function, and clinical relevance
Zhang X, et al. Cell Mol Life Sci 2017 - Review. PMID 28188343
However, emerging evidence suggests that MLL5 is distinct from the other MLL (KMT2) family members, and the protein it encodes appears to lack intrinsic histone methyltransferase (HMT) activity towards histone substrates. ...Recent studies of MLL5 variants and isoforms and putative MLL5 homologs in other species have enriched our understanding of the role of MLL5 in gene expression regulation, although the mechanism of action and physiological function of MLL5 remains poorly understood. ...
However, emerging evidence suggests that MLL5 is distinct from the other MLL (KMT2) family members, and the protein it encodes …
The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome.
Gujar H, et al. Genes (Basel) 2019 - Review. PMID 30813436 Free PMC article.
A DNA sequence is the hard copy of the human genome and it is a driving force in determining the physiological processes in an organism. ...This review mainly focuses on the role of DNMT3B and its isoforms in de novo methylation and maintenance of DNA methylation, especially with respect to their role as an accessory protein....
A DNA sequence is the hard copy of the human genome and it is a driving force in determining the physiological processes in an …
Intron retention as a component of regulated gene expression programs
Jacob AG and Smith CWJ. Hum Genet 2017 - Review. PMID 28391524 Free PMC article.
In organisms such as plants and budding yeast, intron retention is well understood as a major mechanism of gene expression regulation. ...Furthermore, these studies revealed various ways in which intron retention regulates protein isoform production, RNA stability and translation efficiency, and rapid induction of expression via post-transcriptional splicing of retained introns. ...
In organisms such as plants and budding yeast, intron retention is well understood as a major mechanism of gene expression regulation …
A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing.
Wang PH, et al. Nucleic Acids Res 2018. PMID 29547894 Free PMC article.
STING is a core adaptor in innate nucleic acid sensing in mammalian cells, on which different sensing pathways converge to induce type I interferon (IFN) production. ...Here, we reported on a novel transcript isoform of STING designated STING-β that dominantly inhibits innate nucleic acid sensing. ...
STING is a core adaptor in innate nucleic acid sensing in mammalian cells, on which different sensing pathways converge to induce typ …
The monocarboxylate transporter family--role and regulation
Halestrap AP and Wilson MC. IUBMB Life 2012 - Review. PMID 22162139 Free article.
The importance of MCTs is becoming increasingly evident as their extensive physiological and pathological roles are revealed. ...Of particular importance is the upregulation of muscle MCT1 expression in response to training and MCT4 expression in response to hypoxia. ...
The importance of MCTs is becoming increasingly evident as their extensive physiological and pathological roles are revealed. ...Of p …
Posttranslational modifications of neuroligins regulate neuronal and glial signaling
Jeong J, et al. Curr Opin Neurobiol 2017 - Review. PMID 28577430 Free PMC article.
This review covers the dynamic regulation of neuroligin isoforms, focusing on posttranslational events including phosphorylation, glycosylation and activity-dependent cleavage. There is a growing literature on how phosphorylation confers an isoform-specific level of modulation affecting a variety of protein interactions. ...
This review covers the dynamic regulation of neuroligin isoforms, focusing on posttranslational events including phosphorylation, gly …
KDM2A/B lysine demethylases and their alternative isoforms in development and disease.
Vacík T, et al. Nucleus 2018 - Review. PMID 30059280 Free PMC article.
However, little attention has been paid to naturally occurring alternative isoforms of chromatin modifying proteins and to their biological roles. ...These short KDM2A/B-SF isoforms arise through alternative promoter usage and seem to play important roles in development and disease. ...
However, little attention has been paid to naturally occurring alternative isoforms of chromatin modifying proteins and to their biol …
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