Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 1
1958 1
1960 1
1961 2
1962 3
1963 1
1964 3
1965 3
1967 2
1969 1
1971 4
1973 1
1976 2
1977 1
1979 1
1983 3
1984 1
1985 1
1991 1
1992 2
1994 1
1995 1
1997 3
1998 2
1999 9
2000 516
2001 1391
2002 1570
2003 1777
2004 1888
2005 1776
2006 1791
2007 1699
2008 1622
2009 1512
2010 1419
2011 1297
2012 1254
2013 1262
2014 1056
2015 947
2016 962
2017 756
2018 611
2019 238
2020 6
Text availability
Article attribute
Article type
Publication date

Search Results

23,047 results
Results by year
Filters applied: . Clear all
Page 1
Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes
Mashtalir N, et al. Cell 2018. PMID 30343899 Free PMC article.
Finally, we map human disease-associated mutations within subunits and modules, defining specific topological regions that are affected upon subunit perturbation....
Finally, we map human disease-associated mutations within subunits and modules, defining specific topological regions that are affect …
Structure, mechanism, and regulation of the chloroplast ATP synthase
Hahn A, et al. Science 2018. PMID 29748256
We determined the high-resolution structure of the complete cF(1)F(o) complex by cryo-electron microscopy, resolving side chains of all 26 protein subunits, the five nucleotides in the F(1) head, and the proton pathway to and from the rotor ring. ...
We determined the high-resolution structure of the complete cF(1)F(o) complex by cryo-electron microscopy, resolving side chains of all 26 …
Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling.
Shiber A, et al. Nature 2018. PMID 30158700 Free PMC article.
Here we provide a systematic and mechanistic analysis of the assembly of protein complexes in eukaryotes using ribosome profiling. We determined the in vivo interactions of the nascent subunits from twelve hetero-oligomeric protein complexes of Saccharomyces cerevisiae at near-residue resolution. ...
Here we provide a systematic and mechanistic analysis of the assembly of protein complexes in eukaryotes using ribosome profiling. We …
Structure of Telomerase with Telomeric DNA
Jiang J, et al. Cell 2018. PMID 29775593 Free PMC article.
Telomerase is an RNA-protein complex (RNP) that extends telomeric DNA at the 3' ends of chromosomes using its telomerase reverse transcriptase (TERT) and integral template-containing telomerase RNA (TER). ...
Telomerase is an RNA-protein complex (RNP) that extends telomeric DNA at the 3' ends of chromosomes using its telomerase reverse tran …
Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells.
Brennan CM, et al. Genes Dev 2019. PMID 31196865 Free PMC article.
Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of protein complexes encoded on excess chromosomes aggregate in aneuploid cells, which is suppressed when expression of other subunits is coordinately altered. We further show that excess subunits are either degraded or aggregate and that protein aggregation is nearly as effective as protein degradation at lowering levels of excess proteins. ...
Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subu
The split protein phosphatase system.
Bertolotti A. Biochem J 2018 - Review. PMID 30523060 Free PMC article.
Protein kinases are well characterized, but protein phosphatases have been relatively neglected. Protein phosphatase 1 (PP1) catalyzes the dephosphorylation of a major fraction of phospho-serines and phospho-threonines in cells and thereby controls a broad range of cellular processes. ...In this model, a phosphatase and its array of mostly orphan substrate receptors constitute the split protein phosphatase system. ...
Protein kinases are well characterized, but protein phosphatases have been relatively neglected. Protein phosphatase 1
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B
Krzyzosiak A, et al. Cell 2018. PMID 30057111 Free PMC article.
Protein phosphorylation is a prevalent and ubiquitous mechanism of regulation. Kinases are popular drug targets, but identifying selective phosphatase inhibitors has been challenging. ...In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. ...
Protein phosphorylation is a prevalent and ubiquitous mechanism of regulation. Kinases are popular drug targets, but identifying sele
The Immunobiology of the Interleukin-12 Family: Room for Discovery
Tait Wojno ED, et al. Immunity 2019 - Review. PMID 30995503 Free PMC article.
The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family members utilize shared receptors and cytokine subunits and influence the outcome of cancer, infection, and inflammatory diseases. ...
The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to understand the biology of a group of related c …
The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons
Koren I, et al. Cell 2018. PMID 29779948 Free PMC article.
Using a strategy combining global protein stability (GPS) profiling with a synthetic human peptidome, we identify thousands of peptides containing degron activity. ...Thus, we propose that a series of "C-end rules" operate to govern protein stability and shape the eukaryotic proteome....
Using a strategy combining global protein stability (GPS) profiling with a synthetic human peptidome, we identify thousands of peptid …
23,047 results
Jump to page
Feedback