Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1976 1
1997 1
2001 8
2002 179
2003 794
2004 1020
2005 1015
2006 1005
2007 1005
2008 1005
2009 938
2010 855
2011 821
2012 775
2013 819
2014 693
2015 598
2016 661
2017 485
2018 390
2019 144
2020 4
Text availability
Article attribute
Article type
Publication date

Search Results

11,842 results
Results by year
Filters applied: . Clear all
Page 1
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
Mihaylova MM and Shaw RJ. Nat Cell Biol 2011 - Review. PMID 21892142 Free PMC article.
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases. AMPK has critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity. ...
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), whic …
Ribosomal Stalling During Translation: Providing Substrates for Ribosome-Associated Protein Quality Control.
Joazeiro CAP. Annu Rev Cell Dev Biol 2017 - Review. PMID 28715909
In eukaryotes, ribosome-associated quality control (RQC) senses elongation-stalled ribosomes and promotes dissociation of ribosomal subunits. This so-called ribosomal rescue releases the mRNA for degradation and allows 40S subunits to be recycled for new rounds of translation. ...
In eukaryotes, ribosome-associated quality control (RQC) senses elongation-stalled ribosomes and promotes dissociation of ribosomal subun
The Function of V-ATPases in Cancer
Stransky L, et al. Physiol Rev 2016 - Review. PMID 27335445 Free PMC article.
They function in a wide array of normal cellular processes, including membrane traffic, protein processing and degradation, and the coupled transport of small molecules, as well as such physiological processes as urinary acidification and bone resorption. ...Of greatest excitement is evidence that at least some tumors express isoforms of V-ATPase subunits whose disruption is not lethal, leading to the possibility of developing anti-cancer therapeutics that selectively target V-ATPases that function in cancer cells....
They function in a wide array of normal cellular processes, including membrane traffic, protein processing and degradation, and the c …
Structure and mechanism of AMPA receptor - auxiliary protein complexes.
Chen S and Gouaux E. Curr Opin Struct Biol 2019 - Review. PMID 30825796 Free PMC article.
Among the three major families, native AMPA receptors function as complexes with a variety of auxiliary subunits, which in turn modulate receptor trafficking, gating, pharmacology, and permeation. ...Single particle cryo-EM studies have, in turn, provided new insights into the structure and organization of AMPA receptor - auxiliary protein complexes and into the molecular mechanisms of AMPA receptor activation and desensitization....
Among the three major families, native AMPA receptors function as complexes with a variety of auxiliary subunits, which in turn modul …
A Puzzle of Life: Crafting Ribosomal Subunits.
Kressler D, et al. Trends Biochem Sci 2017 - Review. PMID 28579196
Ribosome synthesis is catalyzed and coordinated by more than 200 biogenesis factors as the preribosomal subunits acquire maturity on their path from the nucleolus to the cytoplasm. Several biogenesis factors also interconnect the progression of ribosome assembly with quality control of important domains, ensuring that only functional subunits engage in translation. ...
Ribosome synthesis is catalyzed and coordinated by more than 200 biogenesis factors as the preribosomal subunits acquire maturity on …
Expressing Multi-subunit Complexes Using biGBac
Weissmann F and Peters JM. Methods Mol Biol 2018. PMID 29605925
The reconstitution of recombinant protein complexes is facilitated by methods that allow coexpression of their subunits from a single vector. Here we describe a detailed step-by-step protocol for the biGBac cloning method which can be used to generate baculoviral transfer vectors coding for up to 25 subunits of a protein complex (Weissmann et al., Proc Natl Acad Sci U S A 113(19):E2564-E2569, 2016). biGBac is based on Gibson assembly reactions, optimized DNA linker sequences, and uses a hierarchical two-step assembly procedure. ...
The reconstitution of recombinant protein complexes is facilitated by methods that allow coexpression of their subunits from a …
G protein subunit phosphorylation as a regulatory mechanism in heterotrimeric G protein signaling in mammals, yeast, and plants.
Chakravorty D and Assmann SM. Biochem J 2018 - Review. PMID 30413679 Free PMC article.
Heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits are vital eukaryotic signaling elements that convey information from ligand-regulated G protein-coupled receptors (GPCRs) to cellular effectors. ...This review focuses on phosphorylation of G protein subunits as a regulatory mechanism in mammals, budding yeast, and plants. ...
Heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits are vital eukaryotic signaling elements that convey information from li …
Structural insights into the function of Elongator
Dalwadi U and Yip CK. Cell Mol Life Sci 2018 - Review. PMID 29332244
Conserved from yeast to humans, Elongator is a protein complex implicated in multiple processes including transcription regulation, α-tubulin acetylation, and tRNA modification, and its defects have been shown to cause human diseases such as familial dysautonomia. ...How at the molecular level, Elongator performs its multiple functions and how the different subunits regulate Elongator's activities remains poorly understood. ...
Conserved from yeast to humans, Elongator is a protein complex implicated in multiple processes including transcription regulation, α …
Multisubunit tethers in membrane fusion
Lürick A, et al. Curr Biol 2018 - Review. PMID 29689226 Free article.
Cells are largely compartmentalized into numerous interacting organelles with dedicated functions in lipid metabolism, energy generation, or protein turnover. ...
Cells are largely compartmentalized into numerous interacting organelles with dedicated functions in lipid metabolism, energy generat …
11,842 results
Jump to page
Feedback