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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
1952 1
1953 5
1954 60
1955 130
1956 107
1957 116
1958 147
1959 139
1960 129
1961 103
1962 117
1963 162
1964 147
1965 74
1966 1
1967 3
1968 1
1969 1
1971 1
1974 6
1975 1
1976 2
1977 1
1978 3
1980 1
1981 3
1982 1
1984 2
1985 1
1986 6
1987 28
1988 114
1989 118
1990 56
1991 92
1992 87
1993 114
1994 143
1995 280
1996 492
1997 530
1998 489
1999 496
2000 458
2001 524
2002 487
2003 472
2004 420
2005 367
2006 340
2007 302
2008 320
2009 301
2010 226
2011 193
2012 220
2013 159
2014 149
2015 139
2016 129
2017 115
2018 95
2019 33
2020 0
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9,515 results
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Page 1
Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors.
Kearse MG, et al. Genes Dev 2019. PMID 31171704 Free PMC article.
Here, we used start codon-specific reporters and ribosome profiling to characterize how translation from non-AUG start codons responds to protein synthesis inhibitors in human cells. ...We further found that non-AUG translation is resistant to other inhibitors that target ribosomes within the coding sequence but not those targeting newly initiated ribosomes. ...
Here, we used start codon-specific reporters and ribosome profiling to characterize how translation from non-AUG start codons responds to …
Protein synthesis inhibitors induce both memory impairment and its recovery.
Nikitin VP, et al. Behav Brain Res 2019. PMID 30528939
The involvement of protein synthesis in the mechanisms of conditioned food aversion memory impairment and recovery in grape snails was studied. ...The administration of protein synthesis inhibitors led to impairment of amnesia reactivation and to recovery of the state formed before amnesia induction and thus to the recovery of conditioned food aversion memory....
The involvement of protein synthesis in the mechanisms of conditioned food aversion memory impairment and recovery in grape sn …
Protein Synthesis Inhibitors Did Not Interfere with Long-Term Depression Induced either Electrically in Juvenile Rats or Chemically in Middle-Aged Rats.
Abbas AK. PLoS One 2016. PMID 27517693 Free PMC article.
In testing the hypothesis that long-term potentiation (LTP) maintenance depends on triggered protein synthesis, we found no effect of protein synthesis inhibitors (PSIs) on LTP stabilization. ...The failure of anisomycin to block synaptic-LTD might be relied on the age of animal, the type of protein synthesis inhibitors and/or the inducing protocol. ...
In testing the hypothesis that long-term potentiation (LTP) maintenance depends on triggered protein synthesis, we found no ef …
Protein synthesis controls phosphate homeostasis.
Pontes MH and Groisman EA. Genes Dev 2018. PMID 29437726 Free PMC article.
We now report that impaired protein synthesis alone triggers a Pi starvation response even when Pi is plentiful in the extracellular milieu. ...Notably, pharmacological inhibition of protein synthesis also elicited a Pi starvation response in the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae Our findings identify a regulatory connection between protein synthesis and Pi homeostasis that is widespread in nature....
We now report that impaired protein synthesis alone triggers a Pi starvation response even when Pi is plentiful in the extrace …
Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design
Lin J, et al. Annu Rev Biochem 2018 - Review. PMID 29570352
Structural studies of the ribosome and of its complexes with factors and inhibitors have provided invaluable information on the mechanism of protein synthesis. ...This has spurred a renewed interest in structure-function studies of protein synthesis inhibitors, and in few cases, compounds have been developed into potent therapeutic agents against drug-resistant pathogens. ...
Structural studies of the ribosome and of its complexes with factors and inhibitors have provided invaluable information on the mecha …
Muropeptide signature of inhibitors of protein synthesis correlates with β-lactam synergism against methicillin-resistant Staphylococcus aureus.
Guignard B, et al. Int J Antimicrob Agents 2017. PMID 27887965
The effect extends to other inhibitors of protein synthesis, but not to inhibitors of polynucleotide synthesis or assembly, or to Q/D plus non-β-lactam cell wall inhibitors. ...In this study, we sought to determine whether inhibitors of protein synthesis might produce a specific peptidoglycan muropeptide signature that would correlate with their positive β-lactam interaction. ...
The effect extends to other inhibitors of protein synthesis, but not to inhibitors of polynucleotide synthesi
A genetically encodable cell-type-specific protein synthesis inhibitor.
Heumüller M, et al. Nat Methods 2019. PMID 31308551
Chemical inhibitors have revealed requirements for protein synthesis that drive cellular plasticity. We developed a genetically encodable protein synthesis inhibitor (gePSI) to achieve cell-type-specific temporal control of protein synthesis. Controlled expression of the gePSI in neurons or glia resulted in rapid, potent and reversible cell-autonomous inhibition of protein synthesis. ...
Chemical inhibitors have revealed requirements for protein synthesis that drive cellular plasticity. We developed a gen …
The relationship between protein synthesis and protein degradation in object recognition memory.
Furini CR, et al. Behav Brain Res 2015. PMID 26200717
For decades there has been a consensus that de novo protein synthesis is necessary for long-term memory. A second round of protein synthesis has been described for both extinction and reconsolidation following an unreinforced test session. ...Therefore, it is possible to postulate a direct link between protein degradation and protein synthesis during the reconsolidation of the object recognition memory....
For decades there has been a consensus that de novo protein synthesis is necessary for long-term memory. A second round of …
LTP suppression by protein synthesis inhibitors is NO-dependent.
Maltsev AV, et al. Neuropharmacology 2019. PMID 30540927
For several decades, the ability of protein synthesis inhibitors (PSI) to suppress the long-term potentiation (LTP) of hippocampal responses is known. ...Inhibitory analysis demonstrated that changes during protein synthesis blockade downstream the NO signaling cascade are cGMP-independent and apparently are implemented through degradation of target proteins. ...
For several decades, the ability of protein synthesis inhibitors (PSI) to suppress the long-term potentiation (LTP) of …
Protein synthesis inhibitors of natural origin for CML therapy: semisynthetic homoharringtonine (Omacetaxine mepesuccinate).
Novotny L, et al. Neoplasma 2016 - Review. PMID 27268912
Omacetaxine mepesuccinate is a drug approved in 2014 by FDA for the use in CML therapy in patients resistant to at least two thymidine kinase inhibitors (TKIs). ...Omacetaxine mepesuccinate inhibits protein translation through prevention of the initial elongation step of protein synthesis and its use benefits CML patients possessing the BCR-ABL oncogene. ...
Omacetaxine mepesuccinate is a drug approved in 2014 by FDA for the use in CML therapy in patients resistant to at least two thymidine kinas …
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