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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 2
1969 1
1974 3
1976 1
1978 1
1985 1
1986 2
1987 9
1988 27
1989 30
1990 20
1991 33
1992 20
1993 40
1994 48
1995 68
1996 79
1997 82
1998 84
1999 77
2000 56
2001 58
2002 58
2003 64
2004 56
2005 59
2006 62
2007 68
2008 73
2009 49
2010 42
2011 36
2012 40
2013 29
2014 35
2015 35
2016 34
2017 39
2018 20
2019 14
2020 0
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1,465 results
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Page 1
Protein Synthesis Inhibitors Did Not Interfere with Long-Term Depression Induced either Electrically in Juvenile Rats or Chemically in Middle-Aged Rats.
Abbas AK. PLoS One 2016. PMID 27517693 Free PMC article.
In testing the hypothesis that long-term potentiation (LTP) maintenance depends on triggered protein synthesis, we found no effect of protein synthesis inhibitors (PSIs) on LTP stabilization. ...The failure of anisomycin to block synaptic-LTD might be relied on the age of animal, the type of protein synthesis inhibitors and/or the inducing protocol. ...
In testing the hypothesis that long-term potentiation (LTP) maintenance depends on triggered protein synthesis, we found no ef …
[Roles of protein synthesis inhibitors in long-term potentiation and depotentiation in hippocampal CA1 region of adult rats].
Xie W, et al. Zhejiang Da Xue Xue Bao Yi Xue Ban 2015. PMID 26713530 Chinese.
OBJECTIVE: To study the roles of protein synthesis inhibitors in long-term potentiation(LTP) and depotentiation(DP) in hippocampal CA1 region of adult rats. ...Application of protein synthesis inhibitors after LTP induction does not significantly affect either the amplitude or depotentiation of LTP....
OBJECTIVE: To study the roles of protein synthesis inhibitors in long-term potentiation(LTP) and depotentiation(DP) in hippoca …
High-Throughput Screening for Protein Synthesis Inhibitors Targeting Aminoacyl-tRNA Synthetases.
Kong J, et al. SLAS Discov 2018. PMID 29020503
Aminoacyl-tRNA synthetases (ARSs) exist in large excess in tumor cells due to their increased demand for translation, whereas most other protein-synthesis apparatuses are quantitatively limited. ...Here, we report a high-throughput screening (HTS) system to find mammalian ARS inhibitors. The rabbit-reticulocyte lysate we used closely resembles both the individual and complexed structures of human ARSs, and it may predispose active compounds that are readily applicable for humankind. ...
Aminoacyl-tRNA synthetases (ARSs) exist in large excess in tumor cells due to their increased demand for translation, whereas most ot …
A Microplate-Based Nonradioactive Protein Synthesis Assay: Application to TRAIL Sensitization by Protein Synthesis Inhibitors.
Henrich CJ. PLoS One 2016. PMID 27768779 Free PMC article.
Detection using a pair of near IR-labeled secondary antibodies (InCell western, ICW format) allows quantitative analysis of protein synthesis in 384-well plates. ...The method was then applied to several protein synthesis inhibitors and revealed good correlation between potency as protein synthesis inhibitors to their ability to sensitize TRAIL-resistant renal carcinoma cells to TRAIL-induced apoptosis....
Detection using a pair of near IR-labeled secondary antibodies (InCell western, ICW format) allows quantitative analysis of protein
Incompatibility of chemical protein synthesis inhibitors with accurate measurement of extended protein degradation rates.
Chan C, et al. Pharmacol Res Perspect 2017. PMID 28971619 Free PMC article.
Protein synthesis inhibitors are commonly used for measuring protein degradation rates, but may cause cytotoxicity via direct or indirect mechanisms. ...Actinomycin D, cycloheximide, emetine, and puromycin were assessed individually, and in two-, three-, and four-drug combinations for protein synthesis inhibition (IC(50) ) and cytotoxicity (CC(50) ) over 72 h. ...
Protein synthesis inhibitors are commonly used for measuring protein degradation rates, but may cause cytotoxicity via
Protein synthesis inhibitors, gene superinduction and memory: too little or too much protein?
Radulovic J and Tronson NC. Neurobiol Learn Mem 2008 - Review. PMID 17904877 Free PMC article.
To date, the effects of protein synthesis inhibitors (PSI) in learning and memory processes have been attributed to translational arrest and consequent inhibition of de novo protein synthesis. ...This mechanistic alternative to protein synthesis inhibition is compared to models of electroconvulsive seizures and fragilexsyndrome associated with enhanced mRNA/protein levels and cognitive deficits....
To date, the effects of protein synthesis inhibitors (PSI) in learning and memory processes have been attributed to translatio …
Targeting tumor-initiating cells: eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction.
Lamb R, et al. Oncotarget 2015. PMID 25671304 Free PMC article.
Methionine is absolutely required for protein synthesis, since every protein sequence starts with a methionine residue. Thus, the proliferation and survival of CSCs is very sensitive to the inhibition of protein synthesis, using multiple independent approaches. ...Our data also indicate a novel mechanism by which caloric/protein restriction may reduce tumor growth, by targeting protein synthesis in anabolic tumor-initiating cancer cells....
Methionine is absolutely required for protein synthesis, since every protein sequence starts with a methionine residue. …
Protein synthesis inhibitors delay transneuronal death in the piriform cortex of young adult rats.
López-Mascaraque L and Price JL. Neuroscience 1997. PMID 9200729
It has been demonstrated that apoptotic cell death is an active process that is dependent on RNA and protein synthesis. The question remains as to whether neuronal death in adult, mammalian brains can also be demonstrated in vivo to be dependent on protein synthesis. ...In order to block protein synthesis, three to six subcutaneous injections of the short acting protein synthesis inhibitor anisomycin, were given at 2 h intervals beginning just before the ablation of the olfactory bulb. ...
It has been demonstrated that apoptotic cell death is an active process that is dependent on RNA and protein synthesis. The qu …
Trans-translation and protein synthesis inhibitors.
Vioque A and de la Cruz J. FEMS Microbiol Lett 2003 - Review. PMID 12583891 Free article.
Trans-translation is not essential for cell viability under laboratory conditions, but recently it has been shown that it can contribute to cell viability in the presence of protein synthesis inhibitors. ...
Trans-translation is not essential for cell viability under laboratory conditions, but recently it has been shown that it can contribute to …
Infusion of protein synthesis inhibitors in the entorhinal cortex blocks consolidation but not reconsolidation of object recognition memory.
Lima RH, et al. Neurobiol Learn Mem 2009. PMID 19141326
Our data suggest that protein synthesis in the entorhinal cortex is necessary early after training for consolidation of object recognition memory. However, inhibition of protein synthesis in this cortical region after memory retrieval does not seem to affect the stability of the recognition trace....
Our data suggest that protein synthesis in the entorhinal cortex is necessary early after training for consolidation of object …
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