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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1982 1
1985 1
1986 12
1987 21
1988 32
1989 42
1990 73
1991 116
1992 162
1993 260
1994 422
1995 532
1996 598
1997 691
1998 954
1999 1133
2000 1382
2001 1481
2002 1569
2003 1800
2004 2110
2005 2345
2006 2958
2007 3260
2008 3606
2009 4102
2010 4691
2011 5597
2012 6132
2013 6778
2014 6719
2015 6881
2016 6547
2017 6680
2018 6260
2019 2764
2020 46
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79,055 results
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Page 1
Serine/Threonine Protein Kinases from Bacteria, Archaea and Eukarya Share a Common Evolutionary Origin Deeply Rooted in the Tree of Life.
Stancik IA, et al. J Mol Biol 2018. PMID 29138003 Free article.
The main family of serine/threonine/tyrosine protein kinases present in eukarya was defined and described by Hanks et al. in 1988 (Science, 241, 42-52). ...For historical reasons, the term "eukaryotic-type kinases" propagated in the literature to describe bacterial members of this protein family. ...
The main family of serine/threonine/tyrosine protein kinases present in eukarya was defined and described by Han …
Synthetically Lethal Interactions of ATM, ATR, and DNA-PKcs
Kantidze OL, et al. Trends Cancer 2018 - Review. PMID 30352678
We review here synthetically lethal interactions of ataxia-telangiectasia mutated (ATM), ATM- and Rad3-related (ATR), and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). These kinases are appropriate for synthetic lethal therapies because their genes are frequently mutated in cancer, and specific inhibitors are currently in clinical trials. ...
We review here synthetically lethal interactions of ataxia-telangiectasia mutated (ATM), ATM- and Rad3-related (ATR), and DNA-dependent p
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks.
Magnuson B, et al. Biochem J 2012 - Review. PMID 22168436
The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely defined roles in cellular and organismal physiology. ...The results thus far indicate that the mTORC1-S6K1 axis controls fundamental cellular processes, including transcription, translation, protein and lipid synthesis, cell growth/size and cell metabolism. ...
The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the TORC1 [TOR (target of rapamycin) complex 1], …
Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress.
Wek RC. Cold Spring Harb Perspect Biol 2018 - Review. PMID 29440070 Free PMC article.
Phosphorylation of eIF2α causes inhibition of global translation, which conserves energy and facilitates reprogramming of gene expression and signaling pathways that help to restore protein homeostasis. ...This review highlights the mechanisms regulating eIF2α kinases, the role that uORFs play in translational control, and the impact that alteration of eIF2α phosphorylation by gene mutations or small molecule inhibitors can have on health and disease....
Phosphorylation of eIF2α causes inhibition of global translation, which conserves energy and facilitates reprogramming of gene expression an …
DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation
Lemmens B, et al. Mol Cell 2018. PMID 30008317 Free PMC article.
In the presence of DNA replication, inhibition of CHK1 and p38 leads to premature activation of mitotic kinases, which induces severe replication stress. Our results demonstrate that, rather than merely a cell cycle output, DNA replication is an integral signaling component that restricts activation of mitotic kinases. ...
In the presence of DNA replication, inhibition of CHK1 and p38 leads to premature activation of mitotic kinases, which induces severe …
TOR-mediated regulation of metabolism in aging
Antikainen H, et al. Aging Cell 2017 - Review. PMID 28971552 Free PMC article.
The mTOR pathway promotes protein and lipid synthesis and inhibits autophagy, a process known for its contribution to longevity in several model organisms. ...
The mTOR pathway promotes protein and lipid synthesis and inhibits autophagy, a process known for its contribution to longevity in se …
Reactive oxygen species in the activation of MAP kinases.
Son Y, et al. Methods Enzymol 2013 - Review. PMID 23849857
There are three well-defined subgroups of mitogen-activated protein kinases (MAPKs): the extracellular signal-regulated kinases (ERKs), the c-Jun N-terminal kinases (JNKs), and the p38 MAPKs. ...Reactive oxygen species (ROS), such as hydrogen peroxide, have been reported to activate ERKs, JNKs, and p38 MAPKs, but the mechanisms by which ROS can activate these kinases are unclear. ...
There are three well-defined subgroups of mitogen-activated protein kinases (MAPKs): the extracellular signal-regulated kin
Langerhans cell histiocytosis: A neoplastic disorder driven by Ras-ERK pathway mutations
Tran G, et al. J Am Acad Dermatol 2018 - Review. PMID 29107340
After decades of debate on the disease pathogenesis, a neoplastic mechanism is now favored on the basis of LCH cell clonality, rare cases of familial clustering, and recent evidence of mutations involving the Ras/Raf/MEK (mitogen-activated protein kinase kinase)/ERK (extracellular signal-regulated kinase) pathway in lesional biopsy specimens. ...
After decades of debate on the disease pathogenesis, a neoplastic mechanism is now favored on the basis of LCH cell clonality, rare cases of …
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