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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 4
1947 6
1948 10
1949 5
1950 16
1951 19
1952 11
1953 19
1954 14
1955 22
1956 27
1957 32
1958 22
1959 32
1960 36
1961 23
1962 33
1963 22
1964 27
1965 13
1997 1
2003 1
2007 1
2008 1
2010 5
2011 189
2012 534
2013 514
2014 465
2015 390
2016 445
2017 454
2018 454
2019 315
2020 27
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3,711 results
Results by year
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Page 1
PROteolysis TArgeting Chimeras (PROTACs) - Past, present and future.
Pettersson M, Crews CM. Pettersson M, et al. Drug Discov Today Technol. 2019 Apr;31:15-27. doi: 10.1016/j.ddtec.2019.01.002. Epub 2019 Feb 13. Drug Discov Today Technol. 2019. PMID: 31200855 Free PMC article. Review.
Targeted protein degradation by PROTACs.
Neklesa TK, Winkler JD, Crews CM. Neklesa TK, et al. Pharmacol Ther. 2017 Jun;174:138-144. doi: 10.1016/j.pharmthera.2017.02.027. Epub 2017 Feb 14. Pharmacol Ther. 2017. PMID: 28223226 Review.
Targeted protein degradation: elements of PROTAC design.
Paiva SL, Crews CM. Paiva SL, et al. Curr Opin Chem Biol. 2019 Jun;50:111-119. doi: 10.1016/j.cbpa.2019.02.022. Epub 2019 Apr 17. Curr Opin Chem Biol. 2019. PMID: 31004963 Free PMC article. Review.
GPCR desensitization: Acute and prolonged phases.
Rajagopal S, Shenoy SK. Rajagopal S, et al. Cell Signal. 2018 Jan;41:9-16. doi: 10.1016/j.cellsig.2017.01.024. Epub 2017 Jan 28. Cell Signal. 2018. PMID: 28137506 Free PMC article. Review.
Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.
Crew AP, Raina K, Dong H, Qian Y, Wang J, Vigil D, Serebrenik YV, Hamman BD, Morgan A, Ferraro C, Siu K, Neklesa TK, Winkler JD, Coleman KG, Crews CM. Crew AP, et al. J Med Chem. 2018 Jan 25;61(2):583-598. doi: 10.1021/acs.jmedchem.7b00635. Epub 2017 Jul 10. J Med Chem. 2018. PMID: 28692295
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
Matyskiela ME, Zhang W, Man HW, Muller G, Khambatta G, Baculi F, Hickman M, LeBrun L, Pagarigan B, Carmel G, Lu CC, Lu G, Riley M, Satoh Y, Schafer P, Daniel TO, Carmichael J, Cathers BE, Chamberlain PP. Matyskiela ME, et al. J Med Chem. 2018 Jan 25;61(2):535-542. doi: 10.1021/acs.jmedchem.6b01921. Epub 2017 Apr 20. J Med Chem. 2018. PMID: 28425720
Hsp70 - a master regulator in protein degradation.
Fernández-Fernández MR, Gragera M, Ochoa-Ibarrola L, Quintana-Gallardo L, Valpuesta JM. Fernández-Fernández MR, et al. FEBS Lett. 2017 Sep;591(17):2648-2660. doi: 10.1002/1873-3468.12751. Epub 2017 Jul 25. FEBS Lett. 2017. PMID: 28696498 Free article. Review.
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