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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2010 1
2011 25
2012 84
2013 91
2014 99
2015 87
2016 93
2017 117
2018 101
2019 59
2020 7
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647 results
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Page 1
Targeted protein degradation: expanding the toolbox.
Schapira M, Calabrese MF, Bullock AN, Crews CM. Schapira M, et al. Nat Rev Drug Discov. 2019 Dec;18(12):949-963. doi: 10.1038/s41573-019-0047-y. Epub 2019 Oct 30. Nat Rev Drug Discov. 2019. PMID: 31666732
Targeted protein degradation and the enzymology of degraders.
Fisher SL, Phillips AJ. Fisher SL, et al. Curr Opin Chem Biol. 2018 Jun;44:47-55. doi: 10.1016/j.cbpa.2018.05.004. Epub 2018 Jun 7. Curr Opin Chem Biol. 2018. PMID: 29885948 Review.
Targeted protein degradation by PROTACs.
Neklesa TK, Winkler JD, Crews CM. Neklesa TK, et al. Pharmacol Ther. 2017 Jun;174:138-144. doi: 10.1016/j.pharmthera.2017.02.027. Epub 2017 Feb 14. Pharmacol Ther. 2017. PMID: 28223226 Review.
Development of targeted protein degradation therapeutics.
Chamberlain PP, Hamann LG. Chamberlain PP, et al. Nat Chem Biol. 2019 Oct;15(10):937-944. doi: 10.1038/s41589-019-0362-y. Epub 2019 Sep 16. Nat Chem Biol. 2019. PMID: 31527835 Review.
PROTACs- a game-changing technology.
Konstantinidou M, Li J, Zhang B, Wang Z, Shaabani S, Ter Brake F, Essa K, Dömling A. Konstantinidou M, et al. Expert Opin Drug Discov. 2019 Dec;14(12):1255-1268. doi: 10.1080/17460441.2019.1659242. Epub 2019 Sep 20. Expert Opin Drug Discov. 2019. PMID: 31538491 Free PMC article. Review.
The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study.
Burslem GM, Smith BE, Lai AC, Jaime-Figueroa S, McQuaid DC, Bondeson DP, Toure M, Dong H, Qian Y, Wang J, Crew AP, Hines J, Crews CM. Burslem GM, et al. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. doi: 10.1016/j.chembiol.2017.09.009. Epub 2017 Nov 9. Cell Chem Biol. 2018. PMID: 29129716 Free PMC article.
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16.
Zhang X, Crowley VM, Wucherpfennig TG, Dix MM, Cravatt BF. Zhang X, et al. Nat Chem Biol. 2019 Jul;15(7):737-746. doi: 10.1038/s41589-019-0279-5. Epub 2019 Jun 17. Nat Chem Biol. 2019. PMID: 31209349 Free PMC article.
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