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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 11
1998 40
1999 42
2000 36
2001 44
2002 35
2003 44
2004 54
2005 48
2006 47
2007 58
2008 51
2009 70
2010 85
2011 113
2012 95
2013 126
2014 144
2015 156
2016 120
2017 82
2018 99
2019 51
2020 2
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1,485 results
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Page 1
Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities.
Zhang Y, et al. Mol Cancer 2018 - Review. PMID 29455668 Free PMC article.
c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene) family, and is expressed on the surfaces of various cells. ...We also summarize the connection between c-Met and RON and EGFR, which are also receptor tyrosine kinases. Finally, we introduce the current therapeutic drugs that target c-Met in primary tumors, and their use in clinical research....
c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene) family, and is expressed on the s
HGF/c-MET Signaling in Melanocytes and Melanoma.
Czyz M. Int J Mol Sci 2018 - Review. PMID 30513872 Free PMC article.
The presence of c-MET on keratinocytes is crucial for wound healing in the skin. HGF is not released by normal melanocytes, but as melanocytes express c-MET, they are receptive to HGF, which protects them from apoptosis and stimulates their proliferation and motility. Dissimilar to melanocytes, melanoma cells not only express c-MET, but also release HGF, thus activating c-MET in an autocrine manner. ...
The presence of c-MET on keratinocytes is crucial for wound healing in the skin. HGF is not released by normal melanocytes, bu …
Hepatocyte growth factor/MET in cancer progression and biomarker discovery.
Matsumoto K, et al. Cancer Sci 2017 - Review. PMID 28064454 Free PMC article.
Changes in serum/plasma HGF, soluble MET (sMET), and phospho-MET have been confirmed to be associated with disease progression, metastasis, therapy response, and survival. ...Some of the multi-kinase inhibitors that target MET have received regulatory approval, whereas none of the selective HGF-MET inhibitors have shown efficacy in phase III clinical trials. ...
Changes in serum/plasma HGF, soluble MET (sMET), and phospho-MET have been confirmed to be associated with disease progression …
HGF/c-MET: A Promising Therapeutic Target in the Digestive System Cancers.
Zhang H, et al. Int J Mol Sci 2018 - Review. PMID 30360560 Free PMC article.
The HGF/c-MET pathway is active in the development of digestive system cancers, indicating that inhibition of HGF/c-MET signaling may have therapeutic potential. Various HGF/c-MET signaling inhibitors, mainly c-MET inhibitors, have been tested in clinical trials. The observed efficacy and adverse events of some c-MET inhibitors were not very suitable for treating digestive system cancers. ...
The HGF/c-MET pathway is active in the development of digestive system cancers, indicating that inhibition of HGF/c- …
Expression of the c-Met proto-oncogene and its possible involvement in liver invasion in adult T-cell leukemia.
Imaizumi Y, et al. Clin Cancer Res 2003. PMID 12538467 Free article.
The expressed c-Met should be functional, because hepatocyte growth factor could induce the autophosphorylation of c-Met. Although the viral-transactivating protein Tax has been shown to be involved in the deregulated expression of cellular genes, Tax mRNA was not detected in c-Met mRNA-expressed cell lines. ...Finally, serum transaminase levels were significantly increased in c-Met-positive ATL cases, and all of the infiltrated c-Met-positive cells into liver were shown to be multilobularly nucleated phenotype. ...
The expressed c-Met should be functional, because hepatocyte growth factor could induce the autophosphorylation of c- …
Coexpression of hepatocyte growth factor and c-Met proto-oncogene product in synovial sarcoma.
Motoi T, et al. Pathol Int 1998. PMID 9788260
The HGF receptor is characterized as a c-Met proto-oncogene product (c-Met), which is a heterodimeric tyrosine kinase receptor. ...Immunohistochemical coexpression of HGF and c-Met was demonstrated in the epithelial component of five biphasic SS, while only c-Met was expressed in the epithelioid nests of three monophasic fibrous SS. ...
The HGF receptor is characterized as a c-Met proto-oncogene product (c-Met), which is a heterodime …
HGF/MET and the Immune System: Relevance for Cancer Immunotherapy.
Papaccio F, et al. Int J Mol Sci 2018 - Review. PMID 30441809 Free PMC article.
An overactivation of hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) axis promotes tumorigenesis and tumor progression in various cancer types. Research data recently evidenced that HGF/MET signaling is also involved also in the immune response, mainly modulating dendritic cells functions. ...
An overactivation of hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) axis promotes tumorigenesis and tu …
c-Met Signaling Protects from Nonalcoholic Steatohepatitis- (NASH-) Induced Fibrosis in Different Liver Cell Types.
Drescher HK, et al. Oxid Med Cell Longev 2018. PMID 30538805 Free PMC article.
In addition, animals with a cell-type-specific deletion of c-Met exhibited a strong generation of reactive oxygen species (ROS) by dihydroethidium (hydroethidine) (DHE) staining showing a significant increase in the oxidative stress response especially in LysCre/c-Met(mut) and MxCre/c-Met(mut) animals. ...These results highlight a global protective capacity of c-Met in NASH development and progression....
In addition, animals with a cell-type-specific deletion of c-Met exhibited a strong generation of reactive oxygen species (ROS …
Soluble c-Met is a reliable and sensitive marker to detect c-Met expression level in lung cancer.
Lv H, et al. Biomed Res Int 2015. PMID 25834821 Free PMC article.
c-Met has been demonstrated as an attractive target in lung cancer therapy. Current studies showed that detection of c-Met status in tumor is critical in Met-targeted therapy. ...In c-Met-overexpressed patients, plasma s-Met was significantly increased. And further studies showed that plasma s-Met linearly correlated with c-Met expression in tumor. ...
c-Met has been demonstrated as an attractive target in lung cancer therapy. Current studies showed that detection of c-
Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor.
Gherardi E, et al. Proc Natl Acad Sci U S A 2003. PMID 14528000 Free PMC article.
Little is known about the large ectodomain of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor (HGF/SF). ...Our studies provide 3D models and a functional map of the MET ectodomain. They have broad implications for structure-function of the MET receptor and the related semaphorin and plexin proteins....
Little is known about the large ectodomain of MET, the product of the c-met protooncogene and receptor for hepatocyte g …
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