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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 8
1993 16
1994 35
1995 87
1996 78
1997 82
1998 86
1999 115
2000 131
2001 149
2002 140
2003 173
2004 185
2005 243
2006 225
2007 245
2008 337
2009 432
2010 451
2011 425
2012 467
2013 476
2014 512
2015 513
2016 567
2017 535
2018 474
2019 239
2020 9
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6,737 results
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Page 1
Proton pump inhibitors: Risks of long-term use.
Eusebi LH, et al. J Gastroenterol Hepatol 2017 - Review. PMID 28092694
Proton pump inhibitors are among the most commonly prescribed classes of drugs, and their use is increasing, in particular for long-term treatment, often being over-prescribed and used for inappropriate conditions. ...The most recent literature regarding these adverse effects and their association with long-term proton pump inhibitor treatment is reviewed, and the mechanisms through which these possible complications might develop are discussed....
Proton pump inhibitors are among the most commonly prescribed classes of drugs, and their use is increasing, in particu
Proton-pump inhibitors: understanding the complications and risks.
Malfertheiner P, et al. Nat Rev Gastroenterol Hepatol 2017 - Review. PMID 28930292
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-acid-related diseases. However, in the past decade, a steadily increasing list of complications following long-term use of PPIs has been reported. ...
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-acid-related diseases. Ho
Proton pump inhibitors: use and misuse in the clinical setting.
Savarino V, et al. Expert Rev Clin Pharmacol 2018 - Review. PMID 30295105
The introduction of proton pump inhibitors (PPIs) into clinical practice has greatly improved our therapeutic approach to acid-related diseases for their efficacy and safety. ...
The introduction of proton pump inhibitors (PPIs) into clinical practice has greatly improved our therapeutic approach …
The appropriate use of proton-pump inhibitors.
Savarino V, et al. Minerva Med 2018 - Review. PMID 29856192
The introduction of proton-pump inhibitors (PPIs) into clinical practice since about thirty years has greatly improved our therapeutic approach to acid-related diseases for their well recognized efficacy and safety. ...
The introduction of proton-pump inhibitors (PPIs) into clinical practice since about thirty years has greatly improved …
Proton Pump Inhibitors: Review of Emerging Concerns.
Nehra AK, et al. Mayo Clin Proc 2018 - Review. PMID 29406201
First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized medications worldwide, both in the ambulatory and inpatient clinical settings. ...
First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized medications worldwide, both …
Adverse Events of Proton Pump Inhibitors: Potential Mechanisms.
Corsonello A, et al. Curr Drug Metab 2018 - Review. PMID 29219052
OBJECTIVE: We aimed at summarizing current evidence about mechanisms for potentially harmful effects of Proton Pump Inhibitors (PPIs). ...
OBJECTIVE: We aimed at summarizing current evidence about mechanisms for potentially harmful effects of Proton Pump Inhibit
What are the effects of proton pump inhibitors on the small intestine?
Fujimori S. World J Gastroenterol 2015 - Review. PMID 26078557 Free PMC article.
Generally, proton-pump inhibitors (PPIs) have great benefit for patients with acid related disease with less frequently occurring side effects. ...
Generally, proton-pump inhibitors (PPIs) have great benefit for patients with acid related disease with less frequently …
Proton pump inhibitors for functional dyspepsia.
Pinto-Sanchez MI, et al. Cochrane Database Syst Rev 2017 - Review. PMID 29161458 Free PMC article.
Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in FD, but its efficacy remains controversial. ...OBJECTIVES: To determine the efficacy of proton pump inhibitors in the improvement of global symptoms of dyspepsia and quality of life compared to placebo, H2 receptor antagonists or prokinetics, in people with functional dyspepsia. ...
Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in FD, but …
Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences.
Ortiz-Guerrero G, et al. Neural Plast 2018 - Review. PMID 29755512 Free PMC article.
Recent clinical studies have shown that proton pump inhibitors (PPIs) are associated with risk of dementia, including AD. However, a recent case-control study reported decreased risk of dementia. ...
Recent clinical studies have shown that proton pump inhibitors (PPIs) are associated with risk of dementia, including A …
Interchangeable Use of Proton Pump Inhibitors Based on Relative Potency.
Graham DY and Tansel A. Clin Gastroenterol Hepatol 2018. PMID 28964908 Free PMC article.
Although proton pump inhibitors (PPIs) are widely used, their relative potency and ideal dosing regimens remain unclear. We analyzed data from randomized clinical trials that performed pH testing in patients receiving solid-dose PPI formulations (omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole) for a minimum of 5 days. ...
Although proton pump inhibitors (PPIs) are widely used, their relative potency and ideal dosing regimens remain unclear …
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