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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 2
2001 1
2007 30
2008 146
2009 204
2010 245
2011 218
2012 270
2013 232
2014 255
2015 246
2016 263
2017 268
2018 254
2019 120
2020 4
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2,406 results
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Page 1
Proton pump inhibitors: Risks of long-term use.
Eusebi LH, et al. J Gastroenterol Hepatol 2017 - Review. PMID 28092694
Proton pump inhibitors are among the most commonly prescribed classes of drugs, and their use is increasing, in particular for long-term treatment, often being over-prescribed and used for inappropriate conditions. ...The most recent literature regarding these adverse effects and their association with long-term proton pump inhibitor treatment is reviewed, and the mechanisms through which these possible complications might develop are discussed....
Proton pump inhibitors are among the most commonly prescribed classes of drugs, and their use is increasing, in particu
The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association.
Freedberg DE, et al. Gastroenterology 2017 - Review. PMID 28257716
BACKGROUND & AIMS: The purpose of this review is to evaluate the risks associated with long-term use of proton pump inhibitors (PPIs), focusing on long-term use of PPIs for three common indications: gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), and non-steroidal anti-inflammatory drug (NSAID) bleeding prophylaxis. ...
BACKGROUND & AIMS: The purpose of this review is to evaluate the risks associated with long-term use of proton pump inh
Proton-pump inhibitors: understanding the complications and risks.
Malfertheiner P, et al. Nat Rev Gastroenterol Hepatol 2017 - Review. PMID 28930292
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-acid-related diseases. However, in the past decade, a steadily increasing list of complications following long-term use of PPIs has been reported. ...
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-acid-related diseases. Ho
Proton Pump Inhibitors: Review of Emerging Concerns.
Nehra AK, et al. Mayo Clin Proc 2018 - Review. PMID 29406201
First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized medications worldwide, both in the ambulatory and inpatient clinical settings. ...
First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized medications worldwide, both …
Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline.
Farrell B, et al. Can Fam Physician 2017. PMID 28500192 Free PMC article.
OBJECTIVE: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper or stop proton pump inhibitors (PPIs); to focus on the highest level of evidence available and seek input from primary care professionals in the guideline development, review, and endorsement processes. ...
OBJECTIVE: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper or stop proton
Proton pump inhibitors and osteoporosis.
Andersen BN, et al. Curr Opin Rheumatol 2016 - Review. PMID 27224743
PURPOSE OF REVIEW: The purpose of the review is to provide an update on recent advances in the evidence based on proton pump inhibitors (PPI) as a possible cause of osteoporosis and osteoporotic fractures. ...
PURPOSE OF REVIEW: The purpose of the review is to provide an update on recent advances in the evidence based on proton pump
Adverse Events of Proton Pump Inhibitors: Potential Mechanisms.
Corsonello A, et al. Curr Drug Metab 2018 - Review. PMID 29219052
OBJECTIVE: We aimed at summarizing current evidence about mechanisms for potentially harmful effects of Proton Pump Inhibitors (PPIs). ...
OBJECTIVE: We aimed at summarizing current evidence about mechanisms for potentially harmful effects of Proton Pump Inhibit
The relationship between proton pump inhibitors and renal disease.
Morschel CF, et al. J Bras Nefrol 2018 - Review. PMID 30010692 Free PMC article.
Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. ...
Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the
What are the effects of proton pump inhibitors on the small intestine?
Fujimori S. World J Gastroenterol 2015 - Review. PMID 26078557 Free PMC article.
Generally, proton-pump inhibitors (PPIs) have great benefit for patients with acid related disease with less frequently occurring side effects. ...
Generally, proton-pump inhibitors (PPIs) have great benefit for patients with acid related disease with less frequently …
Proton Pump Inhibitors: Risks and Rewards and Emerging Consequences to the Gut Microbiome.
Singh A, et al. Nutr Clin Pract 2018 - Review. PMID 30071147
In recent years, proton pump inhibitors (PPIs) have been criticized for their various adverse interactions and side effects, creating a dilemma among practitioners regarding their use. ...
In recent years, proton pump inhibitors (PPIs) have been criticized for their various adverse interactions and side eff …
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