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Year Number of Results
2000 2
2001 1
2005 1
2006 5
2007 69
2008 264
2009 353
2010 360
2011 347
2012 392
2013 413
2014 430
2015 429
2016 439
2017 398
2018 367
2019 174
2020 6
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3,920 results
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The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association.
Freedberg DE, et al. Gastroenterology 2017 - Review. PMID 28257716
BACKGROUND & AIMS: The purpose of this review is to evaluate the risks associated with long-term use of proton pump inhibitors (PPIs), focusing on long-term use of PPIs for three common indications: gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), and non-steroidal anti-inflammatory drug (NSAID) bleeding prophylaxis. ...Best Practice Advice 7: Long-term PPI users should not routinely use probiotics to prevent infection. Best Practice Advice 8: Long-term PPI users should not routinely raise their intake of calcium, vitamin B12, or magnesium beyond the Recommended Dietary Allowance (RDA). ...
BACKGROUND & AIMS: The purpose of this review is to evaluate the risks associated with long-term use of proton pump
Proton pump inhibitors: Risks of long-term use.
Eusebi LH, et al. J Gastroenterol Hepatol 2017 - Review. PMID 28092694
Proton pump inhibitors are among the most commonly prescribed classes of drugs, and their use is increasing, in particular for long-term treatment, often being over-prescribed and used for inappropriate conditions. ...The most recent literature regarding these adverse effects and their association with long-term proton pump inhibitor treatment is reviewed, and the mechanisms through which these possible complications might develop are discussed....
Proton pump inhibitors are among the most commonly prescribed classes of drugs, and their use is increasing, in
The appropriate use of proton-pump inhibitors.
Savarino V, et al. Minerva Med 2018 - Review. PMID 29856192
The introduction of proton-pump inhibitors (PPIs) into clinical practice since about thirty years has greatly improved our therapeutic approach to acid-related diseases for their well recognized efficacy and safety. ...Despite the above well-defined indications, however, the use of PPIs continues to grow every year in both Western and Eastern countries and this phenomenon poses serious queries about the appropriate prescription of these drugs worldwide. ...
The introduction of proton-pump inhibitors (PPIs) into clinical practice since about thirty years has greatly improved …
Proton pump inhibitors: use and misuse in the clinical setting.
Savarino V, et al. Expert Rev Clin Pharmacol 2018 - Review. PMID 30295105
The introduction of proton pump inhibitors (PPIs) into clinical practice has greatly improved our therapeutic approach to acid-related diseases for their efficacy and safety. ...Expert Commentary: Despite the above well-defined indications, however, the use of PPIs continues to grow every year in both western and eastern countries and the endless expansion of the PPI market has created important problems for many regulatory authorities for two relevant features: the progressive increase of the costs of therapy and the greater potential harms for the patients. ...
The introduction of proton pump inhibitors (PPIs) into clinical practice has greatly improved our therapeutic ap …
Proton-pump inhibitors: understanding the complications and risks.
Malfertheiner P, et al. Nat Rev Gastroenterol Hepatol 2017 - Review. PMID 28930292
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-acid-related diseases. However, in the past decade, a steadily increasing list of complications following long-term use of PPIs has been reported. ...
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-acid-related diseases. Ho
Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline.
Farrell B, et al. Can Fam Physician 2017. PMID 28500192 Free PMC article.
OBJECTIVE: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper or stop proton pump inhibitors (PPIs); to focus on the highest level of evidence available and seek input from primary care professionals in the guideline development, review, and endorsement processes. ...Uniquely, the guideline development process included a systematic review of PPI deprescribing trials and examination of reviews of the harm of continued PPI use. ...
OBJECTIVE: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper or stop proton
Toxicity of long-term use of proton pump inhibitors in children.
De Bruyne P and Ito S. Arch Dis Child 2018 - Review. PMID 29237614
Proton pump inhibitor (PPI) use is becoming increasingly common. Although the toxicity profiles of PPIs are not well understood particularly in children, PPIs have been associated with increased risks of gastrointestinal and respiratory tract infection, vitamin B(12) deficiency, hypomagnesaemia, bone fractures, and rebound hyperacidity after discontinuation. ...
Proton pump inhibitor (PPI) use is becoming increasingly common. Although the toxicity profiles of PPIs are not well un
Adverse Events of Proton Pump Inhibitors: Potential Mechanisms.
Corsonello A, et al. Curr Drug Metab 2018 - Review. PMID 29219052
OBJECTIVE: We aimed at summarizing current evidence about mechanisms for potentially harmful effects of Proton Pump Inhibitors (PPIs). ...CONCLUSIONS: Current evidence suggests that use of PPIs may be associated with negative outcomes by eliciting several different pathophysiologic mechanisms. ...
OBJECTIVE: We aimed at summarizing current evidence about mechanisms for potentially harmful effects of Proton Pump Inhibit
Proton pump inhibitors for functional dyspepsia.
Pinto-Sanchez MI, et al. Cochrane Database Syst Rev 2017 - Review. PMID 29161458 Free PMC article.
Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in FD, but its efficacy remains controversial. ...OBJECTIVES: To determine the efficacy of proton pump inhibitors in the improvement of global symptoms of dyspepsia and quality of life compared to placebo, H2 receptor antagonists or prokinetics, in people with functional dyspepsia. ...
Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in …
Proton-pump inhibitors and risk of fractures: an update meta-analysis.
Zhou B, et al. Osteoporos Int 2016. PMID 26462494
To identify the relationship between proton-pump inhibitors (PPIs) and the risk of fracture, we conducted an update meta-analysis of observational studies. Results showed that PPI use was associated with a modestly increased risk of hip, spine, and any-site fracture. INTRODUCTION: Many studies have investigated the association of proton-pump inhibitors (PPIs) with fracture risk, but the results have been inconsistent. ...
To identify the relationship between proton-pump inhibitors (PPIs) and the risk of fracture, we conducted an update met …
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