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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 2
2001 1
2004 1
2005 1
2006 9
2007 113
2008 418
2009 572
2010 579
2011 564
2012 630
2013 652
2014 700
2015 679
2016 707
2017 649
2018 611
2019 273
2020 11
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6,326 results
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Page 1
Proton pump inhibitors: use and misuse in the clinical setting.
Savarino V, et al. Expert Rev Clin Pharmacol 2018 - Review. PMID 30295105
The introduction of proton pump inhibitors (PPIs) into clinical practice has greatly improved our therapeutic approach to acid-related diseases for their efficacy and safety. ...Expert Commentary: Despite the above well-defined indications, however, the use of PPIs continues to grow every year in both western and eastern countries and the endless expansion of the PPI market has created important problems for many regulatory authorities for two relevant features: the progressive increase of the costs of therapy and the greater potential harms for the patients. ...
The introduction of proton pump inhibitors (PPIs) into clinical practice has greatly improved our therapeutic ap …
The appropriate use of proton-pump inhibitors.
Savarino V, et al. Minerva Med 2018 - Review. PMID 29856192
The introduction of proton-pump inhibitors (PPIs) into clinical practice since about thirty years has greatly improved our therapeutic approach to acid-related diseases for their well recognized efficacy and safety. ...Despite the above well-defined indications, however, the use of PPIs continues to grow every year in both Western and Eastern countries and this phenomenon poses serious queries about the appropriate prescription of these drugs worldwide. ...
The introduction of proton-pump inhibitors (PPIs) into clinical practice since about thirty years has greatly improved …
Proton-pump inhibitors: understanding the complications and risks.
Malfertheiner P, et al. Nat Rev Gastroenterol Hepatol 2017 - Review. PMID 28930292
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-acid-related diseases. However, in the past decade, a steadily increasing list of complications following long-term use of PPIs has been reported. ...
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-acid-related diseases. Ho
Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline.
Farrell B, et al. Can Fam Physician 2017. PMID 28500192 Free PMC article.
OBJECTIVE: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper or stop proton pump inhibitors (PPIs); to focus on the highest level of evidence available and seek input from primary care professionals in the guideline development, review, and endorsement processes. ...Uniquely, the guideline development process included a systematic review of PPI deprescribing trials and examination of reviews of the harm of continued PPI use. ...
OBJECTIVE: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper or stop proton
The relationship between proton pump inhibitors and renal disease.
Morschel CF, et al. J Bras Nefrol 2018 - Review. PMID 30010692 Free PMC article.
Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. ...Studies have found that prolonged use of PPIs may increase the risk of chronic kidney disease (CKD). The increase in prescription and inadequate use of this class of medication calls for studies on the effects of prolonged PPI therapy on renal function. ...
Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the
Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine.
El Rouby N, et al. Expert Opin Drug Metab Toxicol 2018 - Review. PMID 29620484 Free PMC article.
Proton Pump inhibitors (PPIs) are commonly used for a variety of acid related disorders. Despite the overall effectiveness and safety profile of PPIs, some patients do not respond adequately or develop treatment related adverse events. ...Additionally, the role of CYP2C19 genetic variability in the therapeutic effectiveness or outcomes of PPI therapy is highlighted in details, to provide supporting evidence for the potential value of CYP2C19 genotype-guided approaches to PPI drug therapy. ...
Proton Pump inhibitors (PPIs) are commonly used for a variety of acid related disorders. Despite the overall effectiven
Proton pump inhibitors for functional dyspepsia.
Pinto-Sanchez MI, et al. Cochrane Database Syst Rev 2017 - Review. PMID 29161458 Free PMC article.
Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in FD, but its efficacy remains controversial. ...OBJECTIVES: To determine the efficacy of proton pump inhibitors in the improvement of global symptoms of dyspepsia and quality of life compared to placebo, H2 receptor antagonists or prokinetics, in people with functional dyspepsia. ...
Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in …
Proton pump inhibitors (PPIs) may cause gastric cancer - clinical consequences.
Waldum HL, et al. Scand J Gastroenterol 2018 - Review. PMID 29852782
Recently, two epidemiological studies showed that long-term treatment with proton pump inhibitors (PPIs) increased the risk of gastric cancer. ...Gastro-oesophageal reflux disease (GERD) is the most prevalent condition leading to long-term use of inhibitors of gastric acid secretion. ...
Recently, two epidemiological studies showed that long-term treatment with proton pump inhibitors (PPIs) increased the …
Proton Pump Inhibitors: What the Internist Needs to Know.
Spechler SJ. Med Clin North Am 2019 - Review. PMID 30466666
This report reviews the physiology of gastric acid suppression by proton pump inhibitors (PPIs) and anti-inflammatory effects of PPIs that are independent of their acid-suppressive effects. Valid indications for PPI use are discussed, as are putative adverse effects of PPIs that have been identified through weak associations in observational studies that cannot establish cause-and-effect relationships. ...
This report reviews the physiology of gastric acid suppression by proton pump inhibitors (PPIs) and anti-inflammatory e …
Proton Pump Inhibitors: Risk for Myopathy?
Colmenares EW and Pappas AL. Ann Pharmacother 2017 - Review. PMID 27539734
OBJECTIVE: The purpose of this article is to describe the relationship between proton pump inhibitors (PPIs) and symptoms of myopathy based on case reports. DATA SOURCES: A literature search was conducted in PubMed (1946 to June 2016) using MeSH terms proton pump inhibitors, omeprazole, esomeprazole, lansoprazole, dexlansoprazole, rabeprazole, pantoprazole, and muscular diseases. ...
OBJECTIVE: The purpose of this article is to describe the relationship between proton pump inhibitors (PPIs) and sympto …
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