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94 results

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Page 1
Binuclear Purkinje neurons.
Paltsyn AA, Komissarova SV. Paltsyn AA, et al. Patol Fiziol Eksp Ter. 2016 Oct-Dec;60(4):107-13. Patol Fiziol Eksp Ter. 2016. PMID: 29244931 Review.
In 2003, in research on stem cell transplantation was made the first observations related to the mechanism of the appearance of the second nucleus in Purkinje neurons. The transgender studies in humans and in transgenic experiments on mice have shown that bone marro …
In 2003, in research on stem cell transplantation was made the first observations related to the mechanism of the appearance of the second n …
Programmed cell death in cerebellar Purkinje neurons.
Erekat NS. Erekat NS. J Integr Neurosci. 2022 Jan 28;21(1):30. doi: 10.31083/j.jin2101030. J Integr Neurosci. 2022. PMID: 35164466 Free article. Review.
One or more of these types of programmed cell death may take place in neurons leading to their death in various neurodegenerative disorders in humans. Purkinje neurons (PNs) are among the most highly vulnerable population of neurons to cell death in response to intr …
One or more of these types of programmed cell death may take place in neurons leading to their death in various neurodegenerative disorders …
Spinocerebellar ataxia.
Klockgether T, Mariotti C, Paulson HL. Klockgether T, et al. Nat Rev Dis Primers. 2019 Apr 11;5(1):24. doi: 10.1038/s41572-019-0074-3. Nat Rev Dis Primers. 2019. PMID: 30975995 Review.
Most SCA mutations cause prominent damage to cerebellar Purkinje neurons with consecutive cerebellar atrophy, although Purkinje neurons are only mildly affected in some SCAs. ...
Most SCA mutations cause prominent damage to cerebellar Purkinje neurons with consecutive cerebellar atrophy, although Purk …
Survival strategies for mouse cerebellar Purkinje neurons lacking PMCA2.
Roome CJ, Empson RM. Roome CJ, et al. Neurosci Lett. 2018 Jan 10;663:25-28. doi: 10.1016/j.neulet.2017.09.045. Neurosci Lett. 2018. PMID: 29452612 Review.
The sole output neurons of the cerebellar cortex, Purkinje neurons, are functionally compromised in these knockout mice, yet remarkably these neurons survive. ...We also explore how loss of PMCA2(-/-) can lead to the ataxic phenotype, but can paradoxically also mini …
The sole output neurons of the cerebellar cortex, Purkinje neurons, are functionally compromised in these knockout mice, yet r …
Voltage-gated sodium currents in cerebellar Purkinje neurons: functional and molecular diversity.
Ransdell JL, Nerbonne JM. Ransdell JL, et al. Cell Mol Life Sci. 2018 Oct;75(19):3495-3505. doi: 10.1007/s00018-018-2868-y. Epub 2018 Jul 7. Cell Mol Life Sci. 2018. PMID: 29982847 Free PMC article. Review.
Purkinje neurons, the sole output of the cerebellar cortex, deliver GABA-mediated inhibition to the deep cerebellar nuclei. ...In addition to the rapidly activating and inactivating, or transient, component of the Nav current (I(NaT)) present in many types of centra …
Purkinje neurons, the sole output of the cerebellar cortex, deliver GABA-mediated inhibition to the deep cerebellar nuclei. .. …
Nuclear Ca2+ signalling in cerebellar Purkinje neurons.
Marchenko SM, Thomas RC. Marchenko SM, et al. Cerebellum. 2006;5(1):36-42. doi: 10.1080/14734220600554438. Cerebellum. 2006. PMID: 16527762 Review.
Here we review current data on the mechanisms of regulation of Ca(2+) in the cell nucleus with particular emphasis on cerebellar Purkinje neurons....
Here we review current data on the mechanisms of regulation of Ca(2+) in the cell nucleus with particular emphasis on cerebellar Purkinje …
Cross-talk between DNA damage response and the central carbon metabolic network underlies selective vulnerability of Purkinje neurons in ataxia-telangiectasia.
Sun JK, Wong GC, Chow KH. Sun JK, et al. J Neurochem. 2023 Aug;166(4):654-677. doi: 10.1111/jnc.15881. Epub 2023 Jun 15. J Neurochem. 2023. PMID: 37319113 Review.
The key question arises is how cerebellar Purkinje neurons become selectively vulnerable when all other cell types in the brain are suffering from the very same defects in ATM function. This review intended to comprehensively elaborate the unexpected linkages betwee …
The key question arises is how cerebellar Purkinje neurons become selectively vulnerable when all other cell types in the brai …
Mechanisms of pacemaking in mammalian neurons.
Bean BP. Bean BP. J Physiol. 2024 Sep 20:10.1113/JP284759. doi: 10.1113/JP284759. Online ahead of print. J Physiol. 2024. PMID: 39303139 Free PMC article. Review.
More surprisingly, many neurons in the motor system also show pacemaking activity, often rapid, including cerebellar Purkinje neurons that fire spontaneously at 20-100 Hz, as well as key neurons in the basal ganglia, including subthalamic nucleus neurons and globus …
More surprisingly, many neurons in the motor system also show pacemaking activity, often rapid, including cerebellar Purkinje neur …
Determinants of postsynaptic Ca2+ signaling in Purkinje neurons.
Hartmann J, Konnerth A. Hartmann J, et al. Cell Calcium. 2005 May;37(5):459-66. doi: 10.1016/j.ceca.2005.01.014. Cell Calcium. 2005. PMID: 15820394 Review.
Neuronal integration in Purkinje neurons involves many forms of Ca2+ signaling. Two afferent synaptic inputs, the parallel and the climbing fibers, provide a major drive for these signals. ...Postsynaptically they activate alpha-amino-3-hydroxy-5-methyl-4-propionic …
Neuronal integration in Purkinje neurons involves many forms of Ca2+ signaling. Two afferent synaptic inputs, the parallel and …
94 results