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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 3
1948 2
1950 4
1951 7
1952 4
1953 2
1954 1
1955 2
1956 4
1957 5
1958 1
1959 22
1960 9
1961 8
1962 12
1963 22
1964 28
1965 15
1966 35
1967 25
1968 37
1969 80
1970 73
1971 96
1972 76
1973 70
1974 59
1975 37
1976 47
1977 48
1978 47
1979 46
1980 59
1981 54
1982 55
1983 75
1984 73
1985 88
1986 73
1987 107
1988 109
1989 137
1990 143
1991 74
1992 97
1993 136
1994 141
1995 153
1996 131
1997 196
1998 181
1999 162
2000 181
2001 172
2002 138
2003 139
2004 141
2005 158
2006 186
2007 200
2008 258
2009 266
2010 308
2011 314
2012 321
2013 314
2014 279
2015 217
2016 181
2017 173
2018 140
2019 56
2020 0
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6,864 results
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Page 1
Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging
Chen MK, et al. JAMA Neurol 2018. PMID 30014145 Free PMC article.
Participants underwent high-resolution PET scanning with ((R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one), a compound more commonly known as 11C-UCB-J, for SV2A. ...
Participants underwent high-resolution PET scanning with ((R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrroli
Exploring isoxazoles and pyrrolidinones decorated with the 4,6-dimethoxy-1,3,5-triazine unit as human farnesyltransferase inhibitors.
Lucescu L, et al. Arch Pharm (Weinheim) 2019. PMID 30947375
The replacement of the isoxazole unit by a pyrrolidin-2-one was detrimental to the inhibitory activity while the pyrrolidin-2-thione derivatives conserved the biological potential. ...
The replacement of the isoxazole unit by a pyrrolidin-2-one was detrimental to the inhibitory activity while the pyrrolidin-2- …
Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain
Nabulsi NB, et al. J Nucl Med 2016. PMID 26848175 Free article.
Here we describe the synthesis and characterization of the SV2A PET radiotracer (11)C-UCB-J ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) in nonhuman primates, including whole-body biodistribution. ...
Here we describe the synthesis and characterization of the SV2A PET radiotracer (11)C-UCB-J ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)meth …
Direct Synthesis of 2-Formylpyrrolidines, 2-Pyrrolidinones and 2-Dihydrofuranones via Aerobic Copper-Catalyzed Aminooxygenation and Dioxygenation of 4-Pentenylsulfonamides and 4-Pentenylalcohols.
Wdowik T and Chemler SR. J Am Chem Soc 2017. PMID 28678493 Free PMC article.
The 2-formylpyrrolidines can further undergo oxidative carbon-carbon bond cleavage in situ upon addition of DABCO, providing 2-pyrrolidinones. ...
The 2-formylpyrrolidines can further undergo oxidative carbon-carbon bond cleavage in situ upon addition of DABCO, providing 2-pyrrolidin
[Antiepileptic drugs]
Herranz JL. Rev Neurol 2018. PMID 29876908 Spanish. Free article.
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