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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 97
1996 110
1997 127
1998 142
1999 153
2000 168
2001 166
2002 133
2003 157
2004 208
2005 210
2006 246
2007 266
2008 286
2009 265
2010 272
2011 233
2012 224
2013 192
2014 200
2015 314
2016 212
2017 212
2018 192
2019 168
2020 47
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4,532 results
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Page 1
The RNA exosome and RNA exosome-linked disease.
Morton DJ, et al. RNA 2018 - Review. PMID 29093021 Free PMC article.
The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for both processing and degradation of a variety of RNAs. Cofactors that associate with the RNA exosome likely dictate substrate specificity for this complex. Recently, mutations in genes encoding both structural subunits of the RNA exosome and its cofactors have been linked to human disease. ...
The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for both processing and degradation of a variet …
The RNA modification landscape in human disease.
Jonkhout N, et al. RNA 2017 - Review. PMID 28855326 Free PMC article.
RNA modifications have been historically considered as fine-tuning chemo-structural features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. ...With the advent of direct RNA-sequencing technologies, we expect that this catalog will help prioritize those RNA modifications for transcriptome-wide maps....
RNA modifications have been historically considered as fine-tuning chemo-structural features of infrastructural RNAs, such as rRNAs,
Structural basis of IMP3 RRM12 recognition of RNA.
Jia M, et al. RNA 2018. PMID 30135093 Free PMC article.
The IMP family of RNA binding proteins, also named as insulin-like growth factor 2 (IGF2) mRNA-binding proteins (IGF2BPs), are highly conserved RNA regulators that are involved in many RNA processing stages, including mRNA stability, localization, and translation. ...In the IMP3 RRM12 complex with RNA, only RRM1 is involved in RNA binding and recognizes a dinucleotide sequence....
The IMP family of RNA binding proteins, also named as insulin-like growth factor 2 (IGF2) mRNA-binding proteins (IGF2BPs), are highly …
ADAR RNA editing below the backbone.
Keegan L, et al. RNA 2017 - Review. PMID 28559490 Free PMC article.
ADAR RNA editing enzymes (adenosine deaminases acting on RNA) that convert adenosine bases to inosines were first identified biochemically 30 years ago. ...ADAR RNA editing is a paradigm for the now rapidly expanding range of RNA modifications in mRNAs and ncRNAs. Even with recent progress, much remains to be understood about these groundbreaking ADAR RNA modification systems....
ADAR RNA editing enzymes (adenosine deaminases acting on RNA) that convert adenosine bases to inosines were first identified b …
Ribosome clearance during RNA interference.
Pule MN, et al. RNA 2019. PMID 31110136 Free PMC article.
We investigated this interface by examining the fate of actively translated mRNAs subjected to RNAi in C. elegans Quantifying RNA levels (RNA-seq) and ongoing translation (Ribo-seq), we found there is a greater fold repression of ongoing translation than expected from loss of RNA alone, observing stronger translation repression relative to RNA repression for multiple, independent double-stranded RNA triggers, and for multiple genes. ...Our results expand prior studies that show a role for the SKI RNA helicase complex in removing RNA targets following RNAi in flies and plants, illuminating the widespread role of the nonstop translation surveillance in RNA silencing during RNAi. ...
We investigated this interface by examining the fate of actively translated mRNAs subjected to RNAi in C. elegans Quantifying RNA lev …
UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.
Kim YK and Maquat LE. RNA 2019 - Review. PMID 30655309 Free PMC article.
The key to NMD, no matter what its purpose, is the ATP-dependent RNA helicase upstream frameshift 1 (UPF1), without which NMD fails to occur. ...As examples, UPF1 is engaged in functionally diverse mRNA decay pathways mediated by a variety of RNA-binding proteins that include staufen, stem-loop-binding protein, glucocorticoid receptor, and regnase 1. ...
The key to NMD, no matter what its purpose, is the ATP-dependent RNA helicase upstream frameshift 1 (UPF1), without which NMD fails t …
Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis.
Boneberg FM, et al. RNA 2019. PMID 30910870 Free PMC article.
Eukaryotic ribosome biogenesis is a highly orchestrated process involving numerous assembly factors including ATP-dependent RNA helicases. ...Structural comparisons of the nucleotide-free DHX37-RNA complex with DEAH helicases bound to RNA and ATP analogs reveal conformational changes resulting in a register shift in the bound RNA, suggesting a mechanism for ATP-dependent 3'-5' RNA translocation. ...
Eukaryotic ribosome biogenesis is a highly orchestrated process involving numerous assembly factors including ATP-dependent RNA helic …
Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.
Atkinson SR, et al. RNA 2018. PMID 29914874 Free PMC article.
Based on RNA-seq data from twelve RNA-processing mutants and nine physiological conditions, we identify 5775 novel lncRNAs, nearly 4× the previously annotated lncRNAs. ...Most lncRNAs are cryptic and suppressed by three RNA-processing pathways: the nuclear exosome, cytoplasmic exonuclease, and RNAi. ...
Based on RNA-seq data from twelve RNA-processing mutants and nine physiological conditions, we identify 5775 novel lncRNAs, ne …
Programmable RNA detection with a fluorescent RNA aptamer using optimized three-way junction formation.
Furuhata Y, et al. RNA 2019. PMID 30745364 Free PMC article.
Hence, it is important to detect endogenous RNA for understanding diverse cellular functions and diagnosing diseases. To construct a low-cost and easy-to-use RNA detection probe, a chemically unmodified RNA aptamer that binds to a pro-fluorophore to increase its fluorescence is desirable. ...Based on this, we designed a Broccoli-based RNA detection probe (BRD probe) composed of a sequence of destabilized Broccoli fused with complementary sequences against target RNA. ...
Hence, it is important to detect endogenous RNA for understanding diverse cellular functions and diagnosing diseases. To construct a …
Sequence-specific m(6)A demethylation in RNA by FTO fused to RCas9.
Rau K, et al. RNA 2019. PMID 31263003 Free PMC article.
Sequence-specific demethylation by RCas9-FTO was tested on different RNA combinations and showed up to 15-fold sequence preference for target RNA compared to off-target RNA. Taken together, RCas9-FTO represents a new tool for sequence-specific demethylation of m(6)A in RNA that can be readily adapted to any given RNA sequence and opens the door to studying the function of distinct m(6)A sites....
Sequence-specific demethylation by RCas9-FTO was tested on different RNA combinations and showed up to 15-fold sequence preference fo …
4,532 results
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