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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 3
1946 8
1947 11
1948 19
1949 16
1950 16
1951 29
1952 77
1953 84
1954 94
1955 114
1956 138
1957 95
1958 134
1959 198
1960 241
1961 366
1962 575
1963 1228
1964 1786
1965 1280
1966 1081
1967 1343
1968 1566
1969 1796
1970 1750
1971 1776
1972 1793
1973 1742
1974 1664
1975 1436
1976 1284
1977 1173
1978 1117
1979 1095
1980 917
1981 970
1982 897
1983 924
1984 949
1985 958
1986 915
1987 890
1988 1084
1989 1294
1990 1539
1991 1781
1992 1772
1993 1501
1994 1167
1995 1193
1996 1102
1997 1245
1998 1125
1999 1183
2000 1537
2001 1869
2002 1810
2003 2166
2004 2481
2005 2612
2006 2227
2007 2093
2008 2151
2009 1994
2010 2193
2011 2023
2012 2253
2013 2164
2014 2278
2015 2396
2016 2342
2017 2452
2018 2584
2019 1307
2020 25
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89,455 results
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Page 1
Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions.
Nussbacher JK, et al. Neuron 2019 - Review. PMID 30998900 Free PMC article.
RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. ...Disruption of RNA binding proteins and widespread RNA processing defects are increasingly recognized as critical determinants of neurological diseases. ...
RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and tran
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors.
Grünewald J, et al. Nature 2019. PMID 30995674 Free PMC article.
The most widely used cytosine base editors (CBEs) induce deamination of DNA cytosines using the rat APOBEC1 enzyme, which is targeted by a linked Cas protein-guide RNA complex(3,4). ...Finally, we show that an adenine base editor(7) can also induce transcriptome-wide RNA edits. These results have implications for the use of base editors in both research and clinical settings, illustrate the feasibility of engineering improved variants with reduced RNA editing activities, and suggest the need to more fully define and characterize the RNA off-target effects of deaminase enzymes in base editor platforms....
The most widely used cytosine base editors (CBEs) induce deamination of DNA cytosines using the rat APOBEC1 enzyme, which is targeted by a l …
Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers.
Shi H, et al. Mol Cell 2019 - Review. PMID 31100245 Free PMC article.
However, challenges remain due to the vast heterogeneity in expression abundance of different RNA species, further complicated by divergent cell-type-specific and tissue-specific expression and localization of the effectors as well as modifications. ...We emphasize the importance of context for RNA modification regulation and function....
However, challenges remain due to the vast heterogeneity in expression abundance of different RNA species, further complicated by div …
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis.
Zhou C, et al. Nature 2019. PMID 31181567
For example, the cytosine deaminase APOBEC1-which is used in cytosine base editors (CBEs)-targets both DNA and RNA(12), and the adenine deaminase TadA-which is used in adenine base editors (ABEs)-induces site-specific inosine formation on RNA(9,11). ...Here we quantitatively evaluated RNA single nucleotide variations (SNVs) that were induced by CBEs or ABEs. Both the cytosine base editor BE3 and the adenine base editor ABE7.10 generated tens of thousands of off-target RNA SNVs. ...
For example, the cytosine deaminase APOBEC1-which is used in cytosine base editors (CBEs)-targets both DNA and RNA(12), and the adeni …
Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts.
Litke JL and Jaffrey SR. Nat Biotechnol 2019. PMID 30962542 Free PMC article.
RNA aptamers and RNA aptamer-based devices can be genetically encoded and expressed in cells to probe and manipulate cellular function. ...Here we describe the Tornado (Twister-optimized RNA for durable overexpression) expression system for achieving rapid RNA circularization, resulting in RNA aptamers with high stability and expression levels. ...
RNA aptamers and RNA aptamer-based devices can be genetically encoded and expressed in cells to probe and manipulate cellular
RNA modifications regulating cell fate in cancer.
Delaunay S and Frye M. Nat Cell Biol 2019 - Review. PMID 31048770
The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributor to cancer. ...
The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during deve …
Lysine/RNA-interactions drive and regulate biomolecular condensation.
Ukmar-Godec T, et al. Nat Commun 2019. PMID 31266957 Free PMC article.
Here we show that protein disorder is abundant in protein/RNA granules and lysine is enriched in disordered regions of proteins in P-bodies compared to the entire human disordered proteome. Lysine-rich polypeptides phase separate into lysine/RNA-coacervates that are more dynamic and differ at the molecular level from arginine/RNA-coacervates. ...
Here we show that protein disorder is abundant in protein/RNA granules and lysine is enriched in disordered regions of proteins in P- …
HiChIRP reveals RNA-associated chromosome conformation.
Mumbach MR, et al. Nat Methods 2019. PMID 31133759 Free PMC article.
Here, we present HiChIRP, a method leveraging bio-orthogonal chemistry and optimized chromosome conformation capture conditions, which enables interrogation of chromatin architecture focused around a specific RNA of interest down to approximately ten copies per cell. HiChIRP of three nuclear RNAs reveals insights into promoter interactions (7SK), telomere biology (telomerase RNA component) and inflammatory gene regulation (lincRNA-EPS)....
Here, we present HiChIRP, a method leveraging bio-orthogonal chemistry and optimized chromosome conformation capture conditions, which enabl …
Programmable RNA manipulation in living cells.
Pei Y and Lu M. Cell Mol Life Sci 2019 - Review. PMID 31367845
RNA splicing, modification, trafficking, translation, and stability are all controlled at the transcript level. However, biological tools to study and manipulate them in a programmable fashion are currently limited. In this review, we summarize recent advances regarding available RNA-targeting systems discovered so far, including CRISPR-based technologies-Cas9 and Cas13, and programmable RNA-binding proteins-PUF and PPR. ...
RNA splicing, modification, trafficking, translation, and stability are all controlled at the transcript level. However, biological t
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