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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1972 2
1974 3
1975 2
1977 4
1978 27
1979 26
1980 32
1981 25
1982 37
1983 55
1984 64
1985 68
1986 70
1987 78
1988 121
1989 123
1990 153
1991 188
1992 210
1993 227
1994 220
1995 295
1996 267
1997 292
1998 211
1999 286
2000 285
2001 238
2002 348
2003 437
2004 642
2005 444
2006 664
2007 777
2008 792
2009 763
2010 620
2011 544
2012 612
2013 572
2014 401
2015 403
2016 518
2017 367
2018 366
2019 138
2020 1
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12,076 results
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Page 1
RNA-Seq for Bacterial Gene Expression.
Poulsen LD and Vinther J. Curr Protoc Nucleic Acid Chem 2018. PMID 29927111
RNA sequencing (RNA-seq) has become the preferred method for global quantification of bacterial gene expression. With the continued improvements in sequencing technology and data analysis tools, the most labor-intensive and expensive part of an RNA-seq experiment is the preparation of sequencing libraries, which is also essential for the quality of the data obtained. Here, we present a straightforward and inexpensive basic protocol for preparation of strand-specific RNA-seq libraries from bacterial RNA as well as a computational pipeline for the data analysis of sequencing reads. ...
RNA sequencing (RNA-seq) has become the preferred method for global quantification of bacterial gene expression. With t
Secreted bacterial RNA: an unexplored avenue.
Ghosal A. FEMS Microbiol Lett 2018. PMID 29462301
The role of bacterial-released secreted RNA (seRNA) is mostly unexplored, and the study on seRNA will open a new branch in science. ...
The role of bacterial-released secreted RNA (seRNA) is mostly unexplored, and the study on seRNA will open a new branch in sci …
Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array
Zetsche B, et al. Nat Biotechnol 2017. PMID 27918548 Free PMC article.
Here we show that the ability of Cpf1 to process its own CRISPR RNA (crRNA) can be used to simplify multiplexed genome editing. ...
Here we show that the ability of Cpf1 to process its own CRISPR RNA (crRNA) can be used to simplify multiplexed genome editing. ...
Small RNA-mediated regulation in bacteria: A growing palette of diverse mechanisms.
Dutta T and Srivastava S. Gene 2018 - Review. PMID 29501814
Accumulating studies on bacterial regulatory processes firmly established that sRNAs modulate their target gene expression generally at the posttranscriptional level. ...This review deals with the diverse array of mechanisms, which sRNAs follow to maintain bacterial lifestyle....
Accumulating studies on bacterial regulatory processes firmly established that sRNAs modulate their target gene expression generally …
Mapping the small RNA interactome in bacteria using RIL-seq.
Melamed S, et al. Nat Protoc 2018. PMID 29215635
To enable transcriptome-wide mapping of bacterial sRNA-target pairs, we developed RIL-seq (RNA interaction by ligation and sequencing). RIL-seq is an experimental-computational methodology for capturing sRNA-target interactions in vivo that takes advantage of the mutual binding of the sRNA and target RNA molecules to the RNA chaperone protein Hfq. ...
To enable transcriptome-wide mapping of bacterial sRNA-target pairs, we developed RIL-seq (RNA interaction by ligation and seq …
Riboswitch diversity and distribution
McCown PJ, et al. RNA 2017. PMID 28396576 Free PMC article.
The research findings produced since the first riboswitch validation reports in 2002 reveal that these noncoding RNA domains exploit many different structural features to create binding pockets that are extremely selective for their target ligands. ...Based on our findings, we predict that there are potentially many thousands of distinct bacterial riboswitch classes remaining to be discovered, but that the rarity of individual undiscovered classes will make it increasingly difficult to find additional examples of this RNA-based sensory and gene control mechanism....
The research findings produced since the first riboswitch validation reports in 2002 reveal that these noncoding RNA domains exploit …
An undergraduate laboratory on RNA sequencing analysis of bacterial gene expression.
Militello KT and Reinhardt JA. Biochem Mol Biol Educ 2019. PMID 30681282
Herein, we describe the design, execution, and assessment of a four-week laboratory for junior and senior undergraduate students that focuses on bacterial gene expression changes detected by RNA sequencing (RNA-seq). In the laboratory, students analyze a bacterial RNA-seq dataset in detail and answer questions relating to the impact of DNA methylation on bacterial gene expression. ...
Herein, we describe the design, execution, and assessment of a four-week laboratory for junior and senior undergraduate students that focuse …
SPARTA: Simple Program for Automated reference-based bacterial RNA-seq Transcriptome Analysis.
Johnson BK, et al. BMC Bioinformatics 2016. PMID 26847232 Free PMC article.
RESULTS: To make bacterial RNA-seq data analysis more accessible, we developed a Simple Program for Automated reference-based bacterial RNA-seq Transcriptome Analysis (SPARTA). SPARTA is a reference-based bacterial RNA-seq analysis workflow application for single-end Illumina reads. SPARTA is turnkey software that simplifies the process of analyzing RNA-seq data sets, making bacterial RNA-seq analysis a routine process that can be undertaken on a personal computer or in the classroom. ...
RESULTS: To make bacterial RNA-seq data analysis more accessible, we developed a Simple Program for Automated reference-based …
Large Noncoding RNAs in Bacteria
Harris KA and Breaker RR. Microbiol Spectr 2018 - Review. PMID 29992899 Free PMC article.
Bacterial noncoding RNA (ncRNA) classes longer than 200 nucleotides are rare but are responsible for performing some of the most fundamental tasks in living cells. ...Based on precedents for bacterial large ncRNAs performing sophisticated functions, it seems likely that some of these structured ncRNAs also will prove to carry out complex functions. ...
Bacterial noncoding RNA (ncRNA) classes longer than 200 nucleotides are rare but are responsible for performing some of the mo
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