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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1995 2
1997 1
1998 3
1999 3
2000 8
2001 32
2002 181
2003 648
2004 1607
2005 2469
2006 3051
2007 3806
2008 4385
2009 4999
2010 5319
2011 5853
2012 6357
2013 6483
2014 5922
2015 5803
2016 4908
2017 4358
2018 4310
2019 1745
2020 26
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63,577 results
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Page 1
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Minuesa G, et al. Nat Commun 2019. PMID 31217428 Free PMC article.
We find that the small molecule Ro 08-2750 (Ro) binds directly and selectively to MSI2 and competes for its RNA binding in biochemical assays. ...Thus, we identify a small molecule that targets MSI's oncogenic activity. Our study provides a framework for targeting RNA binding proteins in cancer....
We find that the small molecule Ro 08-2750 (Ro) binds directly and selectively to MSI2 and competes for its RNA binding in bio …
RNA Therapeutics: How Far Have We Gone?
Coutinho MF, et al. Adv Exp Med Biol 2019 - Review. PMID 31342441
In recent years, the RNA molecule became one of the most promising targets for therapeutic intervention. Currently, a large number of RNA-based therapeutics are being investigated both at the basic research level and in late-stage clinical trials. ...RNA-based approaches can act at pre-mRNA level (by splicing modulation/correction using antisense oligonucleotides or U1snRNA vectors), at mRNA level (inhibiting gene expression by siRNAs and antisense oligonucleotides) or at DNA level (by editing mutated sequences through the use of CRISPR/Cas). ...
In recent years, the RNA molecule became one of the most promising targets for therapeutic intervention. Currently, a large number of …
Small interfering RNA targeting of peroxiredoxinⅡ gene enhances formaldehyde-induced toxicity in bone marrow cells isolated from BALB/c mice.
Yu G, et al. Ecotoxicol Environ Saf 2019. PMID 31176251
Afterwards, we used a small interfering RNA (siRNA) to inhibit the expression of PrxⅡ gene, and chose 100 μmol/L FA for exposure dose, to examine the cell viability, ROS level, cell cycle, apoptotic rate, expressions of PrxⅡ gene in BMCs. ...
Afterwards, we used a small interfering RNA (siRNA) to inhibit the expression of PrxⅡ gene, and chose 100 μmol/L FA for …
Promising approaches of small interfering RNAs (siRNAs) mediated cancer gene therapy.
Senapati D, et al. Gene 2019 - Review. PMID 31454539
RNA interference (RNAi) has extensive potential to revolutionize every aspect of clinical application in biomedical research. One of the promising tools is the Small interfering RNA (siRNA) molecules within a cellular component. Principally, siRNA mediated innovative advances are increasing rapidly in support of cancer diagnosis and therapeutic purposes. ...
RNA interference (RNAi) has extensive potential to revolutionize every aspect of clinical application in biomedical research. One of
FIERY1 promotes microRNA accumulation by suppressing rRNA-derived small interfering RNAs in Arabidopsis.
You C, et al. Nat Commun 2019. PMID 31562313 Free PMC article.
Although AGO1 predominantly binds miRNAs in vivo, it also associates with endogenous small interfering RNAs (siRNAs). It is unclear whether the miRNA/siRNA balance affects miRNA activities. Here we report that FIERY1 (FRY1), which is involved in 5'-3' RNA degradation, regulates miRNA abundance and function by suppressing the biogenesis of ribosomal RNA-derived siRNAs (risiRNAs). ...
Although AGO1 predominantly binds miRNAs in vivo, it also associates with endogenous small interfering RNAs (siRNAs). It is un …
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system
Alterman JF, et al. Nat Biotechnol 2019. PMID 31375812 Free PMC article.
Sustained silencing of gene expression throughout the brain using small interfering RNAs (siRNAs) has not been achieved. Here we describe an siRNA architecture, divalent siRNA (di-siRNA), that supports potent, sustained gene silencing in the central nervous system (CNS) of mice and nonhuman primates following a single injection into the cerebrospinal fluid. ...This siRNA design may enable RNA interference-based gene silencing in the CNS for the treatment of neurological disorders....
Sustained silencing of gene expression throughout the brain using small interfering RNAs (siRNAs) has not been achieved. Here …
Interplay between small RNA pathways shapes chromatin landscapes in C. elegans.
Gushchanskaia ES, et al. Nucleic Acids Res 2019. PMID 31216042 Free PMC article.
The nematode Caenorhabditis elegans contains several types of endogenous small interfering RNAs (endo-siRNAs) produced by RNA-dependent RNA polymerase (RdRP) complexes. ...Moreover, our results suggest that enhancer small RNAs may guide local H3K9 methylation....
The nematode Caenorhabditis elegans contains several types of endogenous small interfering RNAs (endo-siRNAs) produced by R
Synergistic effect of STAT3‑targeted small interfering RNA and AZD0530 against glioblastoma in vitro and in vivo.
Liu Q, et al. Mol Med Rep 2019. PMID 31485668 Free PMC article.
The aim of this study was to explore the synergistic effect of signal transducer and activator of transcription 3 (STAT3)‑targeted small interfering (si)RNA and AZD0530 against glioblastoma in vitro and in vivo. ...
The aim of this study was to explore the synergistic effect of signal transducer and activator of transcription 3 (STAT3)‑targeted small
Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo.
Li W, et al. Drug Deliv 2019. PMID 31366257 Free PMC article.
Therefore, Bmi1 gene can be a potential target for small interfering RNA (siRNA) mediated cancer therapy. Ursolic acid (UA) as a natural product plays a pivotal role in anti-tumor field, although its performance is limited by low bioavailability and poor hydrophilicity. ...
Therefore, Bmi1 gene can be a potential target for small interfering RNA (siRNA) mediated cancer therapy. Ursolic acid …
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