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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 2
2002 39
2003 267
2004 649
2005 1107
2006 1417
2007 1577
2008 1845
2009 2191
2010 2472
2011 2749
2012 2955
2013 3296
2014 2772
2015 2674
2016 2654
2017 2305
2018 2051
2019 863
2020 15
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29,854 results
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Page 1
siRNA vs. shRNA: similarities and differences
Rao DD, et al. Adv Drug Deliv Rev 2009 - Review. PMID 19389436
RNA interference (RNAi) is a natural process through which expression of a targeted gene can be knocked down with high specificity and selectivity. ...Methods of mediating the RNAi effect involve small interfering RNA (siRNA), short hairpin RNA (shRNA) and bi-functional shRNA. ...
RNA interference (RNAi) is a natural process through which expression of a targeted gene can be knocked down with high specificity an
Advances in siRNA delivery in cancer therapy
Singh A, et al. Artif Cells Nanomed Biotechnol 2018 - Review. PMID 28423924
RNA interference (RNAi)-based therapeutic approaches are under vibrant scrutinisation to seek cancer cure. siRNA suppress expression of the carcinogenic genes by targeting the mRNA expression. ...
RNA interference (RNAi)-based therapeutic approaches are under vibrant scrutinisation to seek cancer cure. siRNA suppress expression
Delivery materials for siRNA therapeutics
Kanasty R, et al. Nat Mater 2013 - Review. PMID 24150415
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short interfering RNA (siRNA) to the site of action in the cells of target tissues. ...
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNA
Principles of Transgenerational Small RNA Inheritance in Caenorhabditis elegans.
Rechavi O and Lev I. Curr Biol 2017 - Review. PMID 28743023 Free article.
In Caenorhabditis elegans nematodes, such heritable information transmits across generations in the form of RNA-dependent RNA polymerase-amplified small RNAs. ...In this review, we discuss the path that small RNAs take from the soma to the germline, and elaborate on the mechanisms that maintain or erase parental small RNA responses after a specific number of generations. ...
In Caenorhabditis elegans nematodes, such heritable information transmits across generations in the form of RNA-dependent RNA
Journey of siRNA: Clinical Developments and Targeted Delivery
Nikam RR and Gore KR. Nucleic Acid Ther 2018 - Review. PMID 29584585
Since the evolutionary discovery of RNA interference and its utilization for gene knockdown in mammalian cell, a remarkable progress has been achieved in small interfering RNA (siRNA) therapeutics. siRNA is a promising tool, utilized as therapeutic agent against various diseases. ...
Since the evolutionary discovery of RNA interference and its utilization for gene knockdown in mammalian cell, a remarkable progress …
Deep sequencing of virus-derived small interfering RNAs and RNA from viral particles shows highly similar mutational landscapes of a plant virus population.
Kutnjak D, et al. J Virol 2015. PMID 25673712 Free PMC article.
RNA viruses exist within a host as a population of mutant sequences, often referred to as quasispecies. Within a host, sequences of RNA viruses constitute several distinct but interconnected pools, such as RNA packed in viral particles, double-stranded RNA, and virus-derived small interfering RNAs. ...Using ultradeep Illumina sequencing, the diversity of two coexisting Potato virus Y sequence pools present within a plant was investigated: RNA isolated from viral particles and virus-derived small interfering RNAs (the derivatives of a plant RNA silencing mechanism). ...
RNA viruses exist within a host as a population of mutant sequences, often referred to as quasispecies. Within a host, sequences of
Artificial trans-acting small interfering RNA: a tool for plant biology study and crop improvements.
Zhang ZJ. Planta 2014 - Review. PMID 24643516
Of various tools, small RNA-mediated gene silencing platform plays an important and unique role in functional verification of plant genes and trait improvements. Artificial trans-acting small interfering RNA (atasiRNA) has emerged as a potent and specific gene silencing platform which overcomes major limitations of other small RNA silencing approaches including double-stranded RNA, artificial microRNA (amiRNA), and microRNA-induced gene silencing. ...
Of various tools, small RNA-mediated gene silencing platform plays an important and unique role in functional verification of …
Advances in targeted delivery of small interfering RNA using simple bioconjugates.
Nielsen C, et al. Expert Opin Drug Deliv 2014 - Review. PMID 24669756
INTRODUCTION: Development of drugs based on RNA interference by small interfering RNA (siRNA) has been progressing slowly due to a number of challenges associated with the in vivo behavior of siRNA. ...
INTRODUCTION: Development of drugs based on RNA interference by small interfering RNA (siRNA) has been progressing slow …
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing
Nair JK, et al. J Am Chem Soc 2014. PMID 25434769 Free article.
Conjugation of small interfering RNA (siRNA) to an asialoglycoprotein receptor ligand derived from N-acetylgalactosamine (GalNAc) facilitates targeted delivery of the siRNA to hepatocytes in vitro and in vivo. ...
Conjugation of small interfering RNA (siRNA) to an asialoglycoprotein receptor ligand derived from N-acetylgalactosamine (GalN …
Ideal and Reality: Barricade in the Delivery of Small Interfering RNA for Cancer Therapy.
Wu D, et al. Curr Pharm Biotechnol 2016 - Review. PMID 26511977
Small interfering RNA (siRNA) has been demonstrated to be a powerful tool for silencing post-transcriptional gene expression, and thus exhibits great potential in cancer gene therapy. ...
Small interfering RNA (siRNA) has been demonstrated to be a powerful tool for silencing post-transcriptional gene expression,
29,854 results
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