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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 37
2003 269
2004 753
2005 933
2006 735
2007 1032
2008 1262
2009 1596
2010 1483
2011 1678
2012 1709
2013 1949
2014 1886
2015 1886
2016 1854
2017 1790
2018 2044
2019 693
2020 5
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21,037 results
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piRNA Biogenesis in Drosophila melanogaster
Huang X, et al. Trends Genet 2017 - Review. PMID 28964526 Free PMC article.
The PIWI-interacting RNA (piRNA) pathway is a conserved defense system that protects the genome integrity of the animal germline from deleterious transposable elements. Targets of silencing are recognized by small noncoding piRNAs that are processed from long precursor molecules. Although piRNAs and other classes of small noncoding RNAs, such as miRNAs and small interfering (si)RNAs, interact with members of the same family of Argonaute (Ago) proteins and their function in target repression is similar, the biogenesis of piRNAs differs from those of the other two small RNAs. ...
The PIWI-interacting RNA (piRNA) pathway is a conserved defense system that protects the genome integrity of the animal germline from …
Small Interfering RNA Pathway Modulates Initial Viral Infection in Midgut Epithelium of Insect after Ingestion of Virus.
Lan H, et al. J Virol 2015. PMID 26537672 Free PMC article.
Although propagation of viruses in insect vectors can be controlled by the small interfering RNA (siRNA) antiviral pathway, whether the siRNA pathway can control viral dissemination from the midgut epithelium is unknown. ...Here, we show that silencing of the core component Dicer-2 of the small interfering RNA (siRNA) pathway increases viral titers in the midgut epithelium past the threshold (1.99 × 10(9) copies of the SRBSDV P10 gene/μg of midgut RNA) for viral dissemination into the midgut muscles and then into the salivary glands, allowing the SBPH to become a competent vector of SRBSDV. ...
Although propagation of viruses in insect vectors can be controlled by the small interfering RNA (siRNA) antiviral path …
piRNAs: from biogenesis to function
Weick EM and Miska EA. Development 2014 - Review. PMID 25183868 Free article.
siRNA and RNAi optimization
Alagia A and Eritja R. Wiley Interdiscip Rev RNA 2016 - Review. PMID 26840434
The discovery and examination of the posttranscriptional gene regulatory mechanism known as RNA interference (RNAi) contributed to the identification of small interfering RNA (siRNA) and the comprehension of its enormous potential for clinical purposes. ...WIREs RNA 2016, 7:316-329. doi: 10.1002/wrna.1337 For further resources related to this article, please visit the WIREs website....
The discovery and examination of the posttranscriptional gene regulatory mechanism known as RNA interference (RNAi) contributed to th …
Production of Extracellular Vesicles Loaded with Therapeutic Cargo
Lamichhane TN and Jay SM. Methods Mol Biol 2018. PMID 30051423 Free PMC article.
In this chapter, we outline steps for EV isolation and characterization and compare current methods for active and passive loading of EVs with payloads of short interfering RNA (siRNA) or small molecules, with the results revealing that active loading via electroporation increases loading efficiency of siRNA but not of Rhodamine B, a model for a small molecule drug, in HEK293T-derived EVs. The methods described here may inform future design of targeted delivery of nucleic acids or small molecules via EVs....
In this chapter, we outline steps for EV isolation and characterization and compare current methods for active and passive loading of EVs wi …
Small interfering RNA in drug metabolism and transport.
Yu AM. Curr Drug Metab 2007 - Review. PMID 17979658
RNA interference (RNAi) is a powerful technique that utilizes RNA molecules to specifically knock down the expression of targeted gene at posttranscriptional level. These small interfering RNAs (siRNAs) not only have broad application to basic biomedical research but may be developed as therapeutic agents. ...
RNA interference (RNAi) is a powerful technique that utilizes RNA molecules to specifically knock down the expression of targe
Insight of In Vitro Small-Interfering RNA Release From Chitosan Nanoparticles Under Enzymolysis With Förster Resonance Energy Transfer Analysis.
Zhang D, et al. J Pharm Sci 2016. PMID 26554743
Small-interfering RNA (siRNA)-mediated gene silencing with the aid of chitosan (CS)-based carriers has shown efficient and reliable outcome in vitro, but the gene silencing efficiency in vivo is still limited. ...
Small-interfering RNA (siRNA)-mediated gene silencing with the aid of chitosan (CS)-based carriers has shown efficient
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