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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 17
2003 129
2004 302
2005 566
2006 901
2007 1079
2008 1140
2009 1163
2010 1265
2011 1213
2012 1154
2013 896
2014 870
2015 805
2016 683
2017 633
2018 631
2019 288
2020 5
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11,898 results
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Intratracheal Administration of Small Interfering RNA Targeting Fas Reduces Lung Ischemia-Reperfusion Injury.
Del Sorbo L, et al. Crit Care Med 2016. PMID 26963318
INTERVENTIONS: Ischemia-reperfusion injury was induced in lungs isolated from mice, 48 hours after treatment with intratracheal small interfering RNA targeting Fas, control small interfering RNA, or vehicle. ...MEASUREMENTS AND MAIN RESULTS: Fas gene expression was significantly silenced at the level of messenger RNA and protein after ischemia-reperfusion in lungs treated with small interfering RNA targeting Fas compared with lungs treated with control small interfering RNA or vehicle. ...
INTERVENTIONS: Ischemia-reperfusion injury was induced in lungs isolated from mice, 48 hours after treatment with intratracheal small
Immunoprotein-Mediated siRNA Delivery
Bäumer N, et al. Mol Pharm 2017 - Review. PMID 28170265
RNA interference strategies offer an alternative to small molecular drug targeting. Small interfering RNA (siRNA) constitutes a class of molecules that allows the effective and specific inhibition of the biosynthesis of any protein. ...
RNA interference strategies offer an alternative to small molecular drug targeting. Small interfering RNA
Safety of antisense oligonucleotide and siRNA-based therapeutics
Chi X, et al. Drug Discov Today 2017 - Review. PMID 28159625
Two of the more promising platforms are the antisense oligonucleotides (ASOs) and short interfering RNAs (siRNAs), both of which are often directed against similar targets. ...
Two of the more promising platforms are the antisense oligonucleotides (ASOs) and short interfering RNAs (siRNAs), both of which are …
Pulmonary administration of small interfering RNA: The route to go?
Ruigrok MJR, et al. J Control Release 2016 - Review. PMID 27235976
Ever since the discovery of RNA interference (RNAi), which is a post-transcriptional gene silencing mechanism, researchers have been studying the therapeutic potential of using small interfering RNA (siRNA) to treat diseases that are characterized by excessive gene expression. ...
Ever since the discovery of RNA interference (RNAi), which is a post-transcriptional gene silencing mechanism, researchers have been …
Noninvasive approach for enhancing small interfering RNA delivery percutaneously.
Aljuffali IA, et al. Expert Opin Drug Deliv 2016 - Review. PMID 26592090
INTRODUCTION: Topically applied small interfering RNA (siRNA) can be an effective treatment for skin disorders. Using noninvasive strategies can be a safe and effective siRNA-permeation-enhancement approach for facilitating skin delivery. ...
INTRODUCTION: Topically applied small interfering RNA (siRNA) can be an effective treatment for skin disorders. Using n …
Nanovehicle-based Small Interfering RNA (siRNA) Delivery for Therapeutic Purposes: A New Molecular Approach in Pharmacogenomics.
Akhtari J, et al. Curr Clin Pharmacol 2018 - Review. PMID 29992895
BACKGROUND: RNA interference (RNAi) is a process for regulating the gene expression in which small interfering RNAs (siRNAs) silence target genes. siRNA-based therapy as a new molecular treatment approach, offers therapeutic prospects for many common diseases such as cancer and cardiovascular disorders. ...
BACKGROUND: RNA interference (RNAi) is a process for regulating the gene expression in which small interfering RNAs (si …
Preparation of Exosomes for siRNA Delivery to Cancer Cells
Faruqu FN, et al. J Vis Exp 2018. PMID 30582600 Free PMC article.
Small interfering RNA (siRNA), fluorescently labeled with Atto655, is loaded into exosomes by electroporation and excess siRNA is removed by gel filtration. ...
Small interfering RNA (siRNA), fluorescently labeled with Atto655, is loaded into exosomes by electroporation and exces
Novel Survivin-Targeted Small Interfering RNA Delivered by Nanoparticles.
Feng C, et al. Am J Med Sci 2017. PMID 29173363
BACKGROUND: The aim of the present study was to investigate the antitumor effect of our novel survivin-targeted small interfering RNA (siRNA) nanoliposomes on xenograft mouse models with human cervical carcinoma HeLa cells, and to evaluate pharmacokinetics. ...
BACKGROUND: The aim of the present study was to investigate the antitumor effect of our novel survivin-targeted small interfering
Poly(glycerol methacrylate)-based degradable nanoparticles for delivery of small interfering RNA.
Morsi NG, et al. Pharm Dev Technol 2018. PMID 28347210
The purpose of this study is to compare the efficiency and toxicity of aminated linear poly(glycerol methacrylate) (ALT) biodegradable polymer to the most commonly used cationic degradable (i.e. chitosan) and non-degradable (i.e. polyethylenimine (PEI)) polymers for delivery of short interfering RNA (siRNA). ...
The purpose of this study is to compare the efficiency and toxicity of aminated linear poly(glycerol methacrylate) (ALT) biodegradable polym …
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