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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1960 1
1964 1
1967 1
1972 1
1977 1
1978 1
1980 2
1981 24
1982 42
1983 74
1984 91
1985 97
1986 100
1987 115
1988 136
1989 158
1990 259
1991 241
1992 317
1993 337
1994 387
1995 477
1996 472
1997 563
1998 720
1999 1240
2000 1404
2001 1484
2002 1584
2003 1963
2004 3088
2005 4131
2006 5060
2007 6130
2008 7320
2009 8649
2010 10160
2011 11919
2012 13963
2013 15693
2014 16800
2015 18281
2016 17811
2017 18250
2018 19496
2019 9660
2020 215
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176,797 results
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Page 1
Non-coding RNAs as drug targets
Matsui M and Corey DR. Nat Rev Drug Discov 2017 - Review. PMID 27444227 Free PMC article.
Here, we discuss the growing field of ncRNA - including microRNA, intronic RNA, repetitive RNA and long non-coding RNA - and assess the potential and challenges in their therapeutic exploitation....
Here, we discuss the growing field of ncRNA - including microRNA, intronic RNA, repetitive RNA and long non-coding RNA
Non-coding RNAs in human disease
Esteller M. Nat Rev Genet 2011 - Review. PMID 22094949
Evolution and functions of long noncoding RNAs
Ponting CP, et al. Cell 2009 - Review. PMID 19239885 Free article.
RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA species that show complex overlapping patterns of expression and regulation. ...
RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome generates a
Long non-coding RNAs: insights into functions
Mercer TR, et al. Nat Rev Genet 2009 - Review. PMID 19188922
We also consider the medical implications, and the emerging recognition that any transcript, regardless of coding potential, can have an intrinsic function as an RNA....
We also consider the medical implications, and the emerging recognition that any transcript, regardless of coding potential, can have an int …
Analysis RNA-seq and Noncoding RNA.
Arrigoni A, et al. Methods Mol Biol 2016. PMID 27659980
RNA-Seq is an approach to transcriptome profiling that uses deep-sequencing technologies to detect and accurately quantify RNA molecules originating from a genome at a given moment in time. In recent years, the advent of RNA-Seq has facilitated genome-wide expression profiling, including the identification of novel and rare transcripts like noncoding RNAs and novel alternative splicing isoforms.Here, we describe the analytical steps required for the identification and characterization of noncoding RNAs starting from RNA-Seq raw samples, with a particular emphasis on long noncoding RNAs (lncRNAs)....
RNA-Seq is an approach to transcriptome profiling that uses deep-sequencing technologies to detect and accurately quantify RNA
The role of RNA modifications in the regulation of tRNA cleavage.
Lyons SM, et al. FEBS Lett 2018 - Review. PMID 30058219 Free PMC article.
Transfer RNA (tRNA) have been harbingers of many paradigms in RNA biology. They are among the first recognized noncoding RNA (ncRNA) playing fundamental roles in RNA metabolism. ...
Transfer RNA (tRNA) have been harbingers of many paradigms in RNA biology. They are among the first recognized noncoding RN
The noncoding RNA revolution-trashing old rules to forge new ones.
Cech TR and Steitz JA. Cell 2014 - Review. PMID 24679528 Free article.
They regulate gene expression at the levels of transcription, RNA processing, and translation. They protect genomes from foreign nucleic acids. ...For ribozymes and riboswitches, the RNA structure itself provides the biological function, but most ncRNAs operate as RNA-protein complexes, including ribosomes, snRNPs, snoRNPs, telomerase, microRNAs, and long ncRNAs. ...
They regulate gene expression at the levels of transcription, RNA processing, and translation. They protect genomes from foreign nucl …
Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
Thapar R. Molecules 2018 - Review. PMID 30373256 Free PMC article.
Whereas the roles of protein-DNA interactions in HR and NHEJ have been fairly well defined, the functions of small and long non-coding RNAs and RNA-DNA hybrids in the DNA damage response is just beginning to be elucidated. This review summarizes recent discoveries on the identification of non-coding RNAs and RNA-mediated regulation of DSB repair....
Whereas the roles of protein-DNA interactions in HR and NHEJ have been fairly well defined, the functions of small and long non-coding RNAs …
RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites.
Engreitz JM, et al. Cell 2014. PMID 25259926 Free PMC article.
Intermolecular RNA-RNA interactions are used by many noncoding RNAs (ncRNAs) to achieve their diverse functions. To identify these contacts, we developed a method based on RNA antisense purification to systematically map RNA-RNA interactions (RAP-RNA) and applied it to investigate two ncRNAs implicated in RNA processing: U1 small nuclear RNA, a component of the spliceosome, and Malat1, a large ncRNA that localizes to nuclear speckles. ...Interactions with nascent pre-mRNAs cause U1 and Malat1 to localize proximally to chromatin at active genes, demonstrating that ncRNAs can use RNA-RNA interactions to target specific pre-mRNAs and genomic sites. ...
Intermolecular RNA-RNA interactions are used by many noncoding RNAs (ncRNAs) to achieve their diverse functions. To identify t …
176,797 results
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