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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1978 1
1992 7
1993 3
1994 23
1995 35
1996 57
1997 75
1998 76
1999 72
2000 115
2001 128
2002 220
2003 138
2004 174
2005 213
2006 276
2007 328
2008 424
2009 503
2010 545
2011 583
2012 538
2013 439
2014 476
2015 478
2016 469
2017 469
2018 485
2019 214
2020 3
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6,911 results
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Page 1
The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest.
Trendel J, et al. Cell 2019. PMID 30528433 Free article.
Proteins and RNA functionally and physically intersect in multiple biological processes, however, currently no universal method is available to purify protein-RNA complexes. ...Thus, XRNAX is a resourceful approach to study structural and compositional aspects of protein-RNA interactions to address fundamental questions in RNA-biology....
Proteins and RNA functionally and physically intersect in multiple biological processes, however, currently no universal method is av …
Progress in Epigenetics of Depression
Peña CJ and Nestler EJ. Prog Mol Biol Transl Sci 2018 - Review. PMID 29933956 Free PMC article.
Widespread and Functional RNA Circularization in Localized Prostate Cancer.
Chen S, et al. Cell 2019. PMID 30735634 Free article.
Analysis of back-splicing events showed widespread RNA circularization, with the average tumor expressing 7,232 circular RNAs (circRNAs). ...These data advocate for adoption of ultra-deep RNA-seq without poly-A selection to interrogate both linear and circular transcriptomes....
Analysis of back-splicing events showed widespread RNA circularization, with the average tumor expressing 7,232 circular RNAs (circRN …
A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain
Kleaveland B, et al. Cell 2018. PMID 29887379 Free PMC article.
Here, we describe a regulatory network centered on four ncRNAs-a long ncRNA, a circular RNA, and two microRNAs-using gene editing in mice to probe the molecular consequences of disrupting key components of this network. ...By reducing miR-7 levels, Cyrano prevents repression of miR-7-targeted mRNAs and enables accumulation of Cdr1as, a circular RNA known to regulate neuronal activity. ...
Here, we describe a regulatory network centered on four ncRNAs-a long ncRNA, a circular RNA, and two microRNAs-using gene editing in …
ChIRP-MS: RNA-Directed Proteomic Discovery.
Chu C and Chang HY. Methods Mol Biol 2018. PMID 30218357
Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-ms) is a novel technique for studying endogenous ribonucleoprotein complexes. ...In vivo RNA-protein interactions are chemically cross-linked, and purified using biotinylated antisense oligonucleotides against RNA of interest. ...
Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-ms) is a novel technique for studying endogenous rib …
Emerging Roles of Non-Coding RNA Transcription.
Kaikkonen MU and Adelman K. Trends Biochem Sci 2018 - Review. PMID 30145998
Metazoan genomes are broadly transcribed by RNA polymerase II (RNAPII), but surprisingly few of these RNAs encode proteins. Accordingly, there is great interest in understanding the origins and potential roles of the vast array of non-coding RNAs (ncRNAs) that are produced. We present here emerging evidence that the act of transcription and the presence of nascent RNA at a locus is often central to function, rather than specific ncRNA sequences or structures. ...
Metazoan genomes are broadly transcribed by RNA polymerase II (RNAPII), but surprisingly few of these RNAs encode proteins. According …
The role of RNA modifications in the regulation of tRNA cleavage.
Lyons SM, et al. FEBS Lett 2018 - Review. PMID 30058219 Free PMC article.
Transfer RNA (tRNA) have been harbingers of many paradigms in RNA biology. They are among the first recognized noncoding RNA (ncRNA) playing fundamental roles in RNA metabolism. ...
Transfer RNA (tRNA) have been harbingers of many paradigms in RNA biology. They are among the first recognized noncoding RN
The Molecular Biology of HIV Latency
Khoury G, et al. Adv Exp Med Biol 2018 - Review. PMID 30030794
SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability.
Petti E, et al. Nat Commun 2019. PMID 30824709 Free PMC article.
In vertebrates, the telomere repeat containing long, non-coding RNA TERRA is prone to form RNA:DNA hybrids at telomeres. This results in the formation of R-loop structures, replication stress and telomere instability, but also contributes to alternative lengthening of telomeres (ALT). ...Our data identify the RNA binding proteins SFPQ and NONO as novel regulators at telomeres that collaborate to ensure telomere integrity by suppressing telomere fragility and homologous recombination triggered by RNA:DNA hybrids....
In vertebrates, the telomere repeat containing long, non-coding RNA TERRA is prone to form RNA:DNA hybrids at telomeres. This …
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