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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
1960 3
1961 3
1962 44
1963 227
1964 299
1965 297
1966 293
1967 318
1968 360
1969 451
1970 527
1971 580
1972 793
1973 789
1974 842
1975 778
1976 786
1977 780
1978 716
1979 743
1980 748
1981 666
1982 640
1983 591
1984 536
1985 643
1986 643
1987 664
1988 797
1989 939
1990 1063
1991 1164
1992 1194
1993 1406
1994 1553
1995 1823
1996 1757
1997 1908
1998 1972
1999 1988
2000 2052
2001 2019
2002 1890
2003 2015
2004 2194
2005 2363
2006 2572
2007 2497
2008 2604
2009 2803
2010 3058
2011 3233
2012 3051
2013 2963
2014 2904
2015 2722
2016 2631
2017 2452
2018 2294
2019 1052
2020 22
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76,912 results
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Page 1
Viral Regulation of RNA Granules in Infected Cells.
Zhang Q, et al. Virol Sin 2019 - Review. PMID 31037644 Free PMC article.
RNA granules are cytoplasmic, microscopically visible, non-membrane ribo-nucleoprotein structures and are important posttranscriptional regulators in gene expression by controlling RNA translation and stability. TIA/G3BP/PABP-specific stress granules (SG) and GW182/DCP-specific RNA processing bodies (PB) are two major distinguishable RNA granules in somatic cells and contain various ribosomal subunits, translation factors, scaffold proteins, RNA-binding proteins, RNA decay enzymes and helicases to exclude mRNAs from the cellular active translational pool. ...
RNA granules are cytoplasmic, microscopically visible, non-membrane ribo-nucleoprotein structures and are important posttranscription
Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts.
Warmbrod KL, et al. PLoS Pathog 2019. PMID 30947291 Free PMC article.
The presence of bottlenecks in the transmission cycle of many RNA viruses leads to a severe reduction of number of virus particles and this occurs multiple times throughout the viral transmission cycle. Viral replication is then necessary for regeneration of a diverse mutant swarm. It is now understood that any perturbation of the mutation frequency either by increasing or decreasing the accumulation of mutations in an RNA virus results in attenuation of the virus. ...
The presence of bottlenecks in the transmission cycle of many RNA viruses leads to a severe reduction of number of virus particles an …
Impact of a patient-derived hepatitis C viral RNA genome with a mutated microRNA binding site.
Mata M, et al. PLoS Pathog 2019. PMID 31075158 Free PMC article.
Hepatitis C virus (HCV) depends on liver-specific microRNA miR-122 for efficient viral RNA amplification in liver cells. This microRNA interacts with two different conserved sites at the very 5' end of the viral RNA, enhancing miR-122 stability and promoting replication of the viral RNA. Treatment of HCV patients with oligonucleotides that sequester miR-122 resulted in profound loss of viral RNA in phase II clinical trials. ...
Hepatitis C virus (HCV) depends on liver-specific microRNA miR-122 for efficient viral RNA amplification in liver cells. This …
Structures of RIG-I-Like Receptors and Insights into Viral RNA Sensing.
Fan X and Jin T. Adv Exp Med Biol 2019 - Review. PMID 31628656
RIG-I, but not MDA5, adopts an auto-suppression conformation in the absence of RNA. In addition to ligand triggered receptor oligomerization, the activities of these receptors are also regulated by several posttranslational modifications, especially ubiquitination. Overall, these structural studies play critical roles in promoting the understanding of viral RNA recognition mechanisms by the host innate immune system, which also contribute to the designing of drugs for treatment of viral infection. ...
RIG-I, but not MDA5, adopts an auto-suppression conformation in the absence of RNA. In addition to ligand triggered receptor oligomer …
The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.
Cao L, et al. Cell Host Microbe 2019. PMID 31513772
All known PRRs for viral RNA have extranuclear localization. However, for many viruses, replication generates dsRNA in the nucleus. Here, we show that the nuclear matrix protein SAFA (also known as HnRNPU) functions as a nuclear viral dsRNA sensor for both DNA and RNA viruses. ...
All known PRRs for viral RNA have extranuclear localization. However, for many viruses, replication generates dsRNA in the nuc …
Slicing and dicing viruses: antiviral RNA interference in mammals.
Maillard PV, et al. EMBO J 2019 - Review. PMID 30872283 Free PMC article.
Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA-based mechanism, for cell-intrinsic immunity to viruses while vertebrates rely on the protein-based interferon (IFN)-driven innate immune system for the same purpose. ...Here, we discuss cellular and viral factors that impact on antiviral RNAi and the contexts in which this system might be at play in mammalian resistance to viral infection....
Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA-based mechanism, for cell-intrinsic immunity to vi …
Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex.
Kirchdoerfer RN, et al. Acta Crystallogr F Struct Biol Commun 2019. PMID 31045563 Free PMC article.
Replication, transcription and packaging of the viral genome are carried out by the viral nucleocapsid. The nucleocapsid is a complex of the viral nucleoprotein, RNA and several other viral proteins. The nucleoprotein forms large, RNA-bound, helical filaments and acts as a scaffold for additional viral proteins. The 3.1 Å resolution single-particle cryo-electron microscopy structure of the nucleoprotein-RNA helical filament presented here resembles previous structures determined at lower resolution, while providing improved molecular details of protein-protein and protein-RNA interactions. ...
Replication, transcription and packaging of the viral genome are carried out by the viral nucleocapsid. The nucleocapsid is a …
KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.
Sharma NR, et al. Nucleic Acids Res 2019. PMID 31400113 Free PMC article.
Cellular non-membranous RNA-granules, P-bodies (RNA processing bodies, PB) and stress granules (SG), are important components of the innate immune response to virus invasion. ...Here, we report the important roles of GW182 and DDX6, but not Dicer, Ago2 and DCP1A, in PB formation, and that Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection reduces PB formation through several specific interactions with viral RNA-binding protein ORF57. ...
Cellular non-membranous RNA-granules, P-bodies (RNA processing bodies, PB) and stress granules (SG), are important components …
Mosquito antiviral defense mechanisms: a delicate balance between innate immunity and persistent viral infection.
Lee WS, et al. Parasit Vectors 2019 - Review. PMID 30975197 Free PMC article.
Of these host defenses, activation of the RNAi pathway is the main antiviral mechanism, leading to the degradation of viral RNA, thereby inhibiting viral replication and promoting viral clearance. However, whilst antiviral host defense mechanisms limit viral replication, the mosquito immune system is unable to effectively clear the virus. ...
Of these host defenses, activation of the RNAi pathway is the main antiviral mechanism, leading to the degradation of viral RNA
FHL1 is a major host factor for chikungunya virus infection
Meertens L, et al. Nature 2019. PMID 31554973
Despite intensive investigations, the human cellular factors that are critical for CHIKV infection remain unknown, hampering the understanding of viral pathogenesis and the development of anti-CHIKV therapies. ...FHL1 interacts directly with the hypervariable domain of the nsP3 protein of CHIKV and is essential for the replication of viral RNA. ...
Despite intensive investigations, the human cellular factors that are critical for CHIKV infection remain unknown, hampering the understandi …
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