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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1956 2
1957 3
1958 1
1959 1
1960 1
1961 6
1962 3
1966 7
1967 14
1968 7
1969 6
1970 10
1971 15
1972 30
1973 31
1974 35
1975 40
1976 21
1977 30
1978 23
1979 24
1980 22
1981 15
1982 16
1983 14
1984 14
1985 6
1986 11
1987 16
1988 17
1989 30
1990 38
1991 90
1992 135
1993 223
1994 305
1995 363
1996 379
1997 503
1998 611
1999 732
2000 771
2001 739
2002 668
2003 665
2004 709
2005 743
2006 696
2007 773
2008 775
2009 808
2010 880
2011 984
2012 1090
2013 1228
2014 1363
2015 1608
2016 1575
2017 1549
2018 1462
2019 751
2020 14
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21,779 results
Results by year
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Page 1
exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes.
Li S, et al. Nucleic Acids Res 2018. PMID 30053265 Free PMC article.
Here, we develop a web-accessible database (http://www.exoRBase.org), exoRBase, which is a repository of circular RNA (circRNA), long non-coding RNA (lncRNA) and messenger RNA (mRNA) derived from RNA-seq data analyses of human blood exosomes. Experimental validations from the published literature are also included. exoRBase features the integration and visualization of RNA expression profiles based on normalized RNA-seq data spanning both normal individuals and patients with different diseases. exoRBase aims to collect and characterize all long RNA species in human blood exosomes. ...
Here, we develop a web-accessible database (http://www.exoRBase.org), exoRBase, which is a repository of circular RNA (circRNA), long …
Dried Blood Spot RNA Transcriptomes Correlate with Transcriptomes Derived from Whole Blood RNA.
Reust MJ, et al. Am J Trop Med Hyg 2018. PMID 29512483 Free PMC article.
Obtaining RNA from clinical samples collected in resource-limited settings can be costly and challenging. The goals of this study were to 1) optimize messenger RNA extraction from dried blood spots (DBS) and 2) determine how transcriptomes generated from DBS RNA compared with RNA isolated from blood collected in Tempus tubes. ...Dried blood spots for transcriptome studies could be an option when field conditions preclude appropriate collection, storage, or transport of whole blood for RNA studies....
Obtaining RNA from clinical samples collected in resource-limited settings can be costly and challenging. The goals of this study wer …
Comparison of six different pretreatment methods for blood RNA extraction.
Liu X, et al. Biopreserv Biobank 2015. PMID 25686049
Human blood specimens serve as important research materials in the field of translational medicine research. The RNA extracted from blood, for example, represents the gene expression profiles of individuals or groups, and can be indicative of the pathological basis for human diseases. ...In this study, six different pretreatment methods are evaluated for their effects on blood RNA extraction including the RNA yields and quality. ...
Human blood specimens serve as important research materials in the field of translational medicine research. The RNA extracted …
Inter-Individual Differences in RNA Levels in Human Peripheral Blood.
Chomczynski P, et al. PLoS One 2016. PMID 26863434 Free PMC article.
The individual RNA level ranged from 6.7 to 22.7 μg/ml of blood. In healthy subjects, the repeated sampling of an individual's blood showed that RNA level, whether high or low, was stable. The inter-individual differences in RNA level in blood can be attributed to both, differences in cell number and the amount of RNA per cell. ...
The individual RNA level ranged from 6.7 to 22.7 μg/ml of blood. In healthy subjects, the repeated sampling of an individual's …
Comparison of blood RNA isolation methods from samples stabilized in Tempus tubes and stored at a large human biobank.
Aarem J, et al. BMC Res Notes 2016. PMID 27587079 Free PMC article.
In this study, we systematically evaluated and compared five blood-RNA isolation protocols: three blood-RNA isolation protocols optimized for simultaneous isolation of all blood-RNA species (MagMAX RNA Isolation Kit, both manual and semi-automated protocols; and Norgen Preserved Blood RNA kit I); and two protocols optimized for large RNAs only (Tempus Spin RNA, and Tempus 6-port isolation kit). ...Some differences in the RNA processing time and cost were noted. CONCLUSIONS: Sufficient amounts of high-quality RNA were obtained using all five protocols, and the Tempus blood RNA system therefore seems not to be dependent on one specific RNA isolation method....
In this study, we systematically evaluated and compared five blood-RNA isolation protocols: three blood-RNA isol …
A comprehensive profile of circulating RNAs in human serum
Umu SU, et al. RNA Biol 2018. PMID 29219730 Free PMC article.
In this study, we used RNA sequencing (RNA-seq) to investigate the profile of small non-coding RNA (sncRNA) in human serum. We analyzed 10 billion Illumina reads from 477 serum samples, included in the Norwegian population-based Janus Serum Bank (JSB). ...In addition, the presence of specific fragments of tRNA, snoRNA, Vault RNA and Y_RNA indicates protection from degradation. Our results suggest that many circulating RNAs in serum can be potential biomarkers....
In this study, we used RNA sequencing (RNA-seq) to investigate the profile of small non-coding RNA (sncRNA) in human se …
RNA-Seq blood transcriptome profiling in familial attention deficit and hyperactivity disorder (ADHD).
Lorenzo G, et al. Psychiatry Res 2018. PMID 30343239
We have carried an exploratory study by blood transcriptome to find RNA expression signatures in familial ADHD. Samples were collected from three cases with familial ADHD and their paired controls and evaluated by RNA-Seq. ...These findings show that blood transcriptome can have an associated signature and highlight a potential to use blood transcriptome to identify patterns of ADHD....
We have carried an exploratory study by blood transcriptome to find RNA expression signatures in familial ADHD. Samples were c …
Platelet RNA signatures for the detection of cancer.
Sol N and Wurdinger T. Cancer Metastasis Rev 2017 - Review. PMID 28681241 Free PMC article.
Platelets are equipped with RNA processing machineries, such as pre-mRNA splicing, pre-miRNA processing, and mRNA translation. ...In this review, we discuss how platelet RNA biomarker signatures can be altered in the presence of cancer....
Platelets are equipped with RNA processing machineries, such as pre-mRNA splicing, pre-miRNA processing, and mRNA translation. ...In …
Cell-free nucleic acids as biomarkers in cancer patients
Schwarzenbach H, et al. Nat Rev Cancer 2011 - Review. PMID 21562580
DNA, mRNA and microRNA are released and circulate in the blood of cancer patients. Changes in the levels of circulating nucleic acids have been associated with tumour burden and malignant progression. ...In this Review, we discuss these findings with a specific focus on the clinical utility of cell-free nucleic acids as blood biomarkers....
DNA, mRNA and microRNA are released and circulate in the blood of cancer patients. Changes in the levels of circulating nucleic acids …
Phospho-RNA-seq: a modified small RNA-seq method that reveals circulating mRNA and lncRNA fragments as potential biomarkers in human plasma.
Giraldez MD, et al. EMBO J 2019. PMID 31053596 Free PMC article.
Although extracellular microRNAs in blood plasma are extensively characterized, extracellular messenger RNA (mRNA) and long non-coding RNA (lncRNA) studies are limited. ...These fragments were revealed using a modified protocol ("phospho-RNA-seq") incorporating RNA treatment with T4-polynucleotide kinase, which we compared with standard small RNA-seq for sequencing synthetic RNAs with varied 5' and 3' ends, as well as human plasma exRNA Analyzing phospho-RNA-seq data using a custom, high-stringency bioinformatic pipeline, we identified mRNA/lncRNA transcriptome fingerprints in plasma, including tissue-specific gene sets. ...
Although extracellular microRNAs in blood plasma are extensively characterized, extracellular messenger RNA (mRNA) and long no …
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