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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 2
2002 149
2003 747
2004 1415
2005 1976
2006 2449
2007 2695
2008 2938
2009 3229
2010 3943
2011 4208
2012 4927
2013 5004
2014 4870
2015 5363
2016 4431
2017 4100
2018 3158
2019 1217
2020 26
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50,586 results
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Page 1
RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?
Bobbin ML and Rossi JJ. Annu Rev Pharmacol Toxicol 2016 - Review. PMID 26738473
A resurgence in clinical trials using RNA interference (RNAi) occurred in 2012. Although there were initial difficulties in achieving efficacious results with RNAi without toxic side effects, advances in delivery and improved chemistry made this resurgence possible. ...
A resurgence in clinical trials using RNA interference (RNAi) occurred in 2012. Although there were initial difficulties in ac …
RNA Interference Mechanisms and Applications in Plant Pathology.
Rosa C, et al. Annu Rev Phytopathol 2018 - Review. PMID 29979927
The origin of RNA interference (RNAi), the cell sentinel system widely shared among eukaryotes that recognizes RNAs and specifically degrades or prevents their translation in cells, is suggested to predate the last eukaryote common ancestor ( 138 ). ...Here, we review the discovery of RNAi, canonical mechanisms, experimental and translational applications, and new RNA-based technologies of importance to plant pathology....
The origin of RNA interference (RNAi), the cell sentinel system widely shared among eukaryotes that recognizes RNAs and specif …
RNA interference: biology, mechanism, and applications.
Agrawal N, et al. Microbiol Mol Biol Rev 2003 - Review. PMID 14665679 Free PMC article.
Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of silencing gene expression in a range of organisms. ...Several key components such as Dicer, RNA-dependent RNA polymerase, helicases, and dsRNA endonucleases have been identified in different organisms for their roles in RNAi. ...
Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of silencing gene expression in a range of organ …
An RNA toolbox for cancer immunotherapy.
Pastor F, et al. Nat Rev Drug Discov 2018 - Review. PMID 30190565
RNA-based structures have diverse functions, ranging from gene expression and gene regulation to pro-inflammatory effects and the ability to specifically bind different molecules. ...Nascent RNA immunotherapeutics include RNA vaccines encoding cancer neoantigens, mRNAs encoding immunomodulatory factors, viral RNA analogues, interference RNAs and protein-binding RNA aptamers. ...
RNA-based structures have diverse functions, ranging from gene expression and gene regulation to pro-inflammatory effects and the abi
RNA Interference in Planarians: Feeding and Injection of Synthetic dsRNA.
Shibata N and Agata K. Methods Mol Biol 2018. PMID 29916171
RNA interference (RNAi) is one of the simplest and easiest methods for specifically perturbing gene function in an organism. ...Here, we describe protocols to synthesize and deliver synthetic double-stranded RNA (dsRNA) to planarians, either by injection or by feeding. ...
RNA interference (RNAi) is one of the simplest and easiest methods for specifically perturbing gene function in an organism. .
Pharmacology of Antisense Drugs
Bennett CF, et al. Annu Rev Pharmacol Toxicol 2017 - Review. PMID 27732800
Antisense oligonucleotides are the most direct means to target RNA in a selective manner and have become an established platform technology for drug discovery. There are multiple molecular mechanisms by which antisense oligonucleotides can be used to modulate RNAs in cells, including promoting the degradation of the targeted RNA or modulating RNA function without degradation. ...
Antisense oligonucleotides are the most direct means to target RNA in a selective manner and have become an established platform tech …
Systemic RNA Interference in Planarians by Feeding of dsRNA Containing Bacteria.
Adler CE and Alvarado AS. Methods Mol Biol 2018. PMID 29916170
RNA interference (RNAi) is currently the only method available in planaria for assessing the function of particular genes. We describe here a method for performing body-wide gene knockdown, relying on dsRNA production in bacteria and subsequent delivery to planaria by feeding a liver-bacteria mixture. ...
RNA interference (RNAi) is currently the only method available in planaria for assessing the function of particular genes. We
Angiogenesis regulation by nanocarriers bearing RNA interference.
Ofek P, et al. Adv Drug Deliv Rev 2017 - Review. PMID 28163106
RNA interference approaches offer the possibility of rational design with high specificity, lacking in many current drug treatments for various diseases including cancer. ...We present pro-angiogenic and anti-angiogenic factors as potential targets, experimental evidence and clinical trials data on angiogenesis regulation by RNA interference. ...
RNA interference approaches offer the possibility of rational design with high specificity, lacking in many current drug treat
Nano-based delivery of RNAi in cancer therapy
Xin Y, et al. Mol Cancer 2017 - Review. PMID 28754120 Free PMC article.
BACKGROUND: RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. ...OBJECTIVE: This review presents an overview of the mechanisms of RNAi molecules in gene therapy and the different nanoparticles used to deliver RNAi molecules; briefly describes the current uses of RNAi in cancer therapy along with the nano-based delivery of RNA molecules in previous studies; and highlights some other carriers that have been applied in clinical settings. ...
BACKGROUND: RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recen …
Practical Use of RNA Interference: Oral Delivery of Double-stranded RNA in Liposome Carriers for Cockroaches.
Huang JH, et al. J Vis Exp 2018. PMID 29782022 Free PMC article.
RNA interference (RNAi) has been widely applied for uncovering the biological functions of numerous genes, and has been envisaged as a pest control tool operating by disruption of essential gene expression. Although different methods, such as injection, feeding, and soaking, have been reported for successful delivery of double-stranded RNA (dsRNA), the efficiency of RNAi through oral delivery of dsRNA is highly variable among different insect groups. ...
RNA interference (RNAi) has been widely applied for uncovering the biological functions of numerous genes, and has been envisa
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