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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1962 1
1967 4
1968 1
1974 5
1979 2
1983 2
1986 3
1987 10
1988 30
1989 1138
1990 2315
1991 313
1992 475
1993 707
1994 1300
1995 1497
1996 1410
1997 1674
1998 2049
1999 2493
2000 2987
2001 3737
2002 4323
2003 4870
2004 5348
2005 5438
2006 5875
2007 5614
2008 6354
2009 7024
2010 7355
2011 7536
2012 7651
2013 7986
2014 7692
2015 7984
2016 8359
2017 8671
2018 9135
2019 4857
2020 125
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Search Results

133,485 results
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Page 1
Randomised, double-blind, placebo-controlled trials of non-individualised homeopathic treatment: systematic review and meta-analysis.
Mathie RT, et al. Syst Rev 2017 - Review. PMID 28340607 Free PMC article.
BACKGROUND: A rigorous systematic review and meta-analysis focused on randomised controlled trials (RCTs) of non-individualised homeopathic treatment has not previously been reported. ...Forty-nine trials were classed as 'high risk of bias' and 23 as 'uncertain risk of bias'; the remaining three, clinically heterogeneous, trials displayed sufficiently low risk of bias to be designated reliable evidence. ...
BACKGROUND: A rigorous systematic review and meta-analysis focused on randomised controlled trials (RCTs) of non-individualise …
Methods of defining the non-inferiority margin in randomized, double-blind controlled trials: a systematic review.
Althunian TA, et al. Trials 2017 - Review. PMID 28270184 Free PMC article.
METHODS: A systematic PubMed search was conducted for all published randomized, double-blind, non-inferiority trials from January 1, 1966, to February 6, 2015. ...Authors, reviewers, and editors need to take notice of reporting this critical information to allow for better judgment of non-inferiority trials....
METHODS: A systematic PubMed search was conducted for all published randomized, double-blind, non-inferiority trials from Janu …
Randomized controlled trials in environmental health research: unethical or underutilized?
Allen RW, et al. PLoS Med 2015. PMID 25562846 Free PMC article.
Ryan Allen and colleagues argue that more randomized controlled trials in environmental health would complement a strong tradition of observational research. ...
Ryan Allen and colleagues argue that more randomized controlled trials in environmental health would complement a stron …
CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials.
Schulz KF, et al. BMJ 2010. PMID 20332509 Free PMC article.
The CONSORT statement is used worldwide to improve the reporting of randomised controlled trials. Kenneth Schulz and colleagues describe the latest version, CONSORT 2010, which updates the reporting guideline based on new methodological evidence and accumulating experience...
The CONSORT statement is used worldwide to improve the reporting of randomised controlled trials. Kenneth Schulz and colleague …
Safety data from randomized controlled trials: applying models for recurrent events.
Hengelbrock J, et al. Pharm Stat 2016. PMID 27291933
Simple descriptive listings and inference statistics based on 2×2 tables are still the most common way of summarizing and reporting adverse events data from randomized controlled trials, although these methods do not account for differences in observation times between treatment groups. ...As an alternative, we discuss two models for recurrent events data-the Andersen-Gill and Prentice-Williams-Peterson model-regarding their applicability to safety data from randomized controlled trials. ...
Simple descriptive listings and inference statistics based on 2×2 tables are still the most common way of summarizing and reporting adverse …
Randomized controlled trials in plastic surgery: a 20-year review of reporting standards, methodologic quality, and impact.
Taghinia AH, et al. Plast Reconstr Surg 2008. PMID 18827662
The relative impact of randomized controlled trials in plastic surgery was compared with that in other specialties. RESULTS: A total of 163 randomized controlled trials were evaluated. ...Nonsurgical trials had significantly higher quality and impact than surgical trials. Randomized controlled trials in plastic surgery had relatively lower impact as compared with randomized controlled trials in other specialties. ...
The relative impact of randomized controlled trials in plastic surgery was compared with that in other specialties. RES …
Proposals to Conduct Randomized Controlled Trials Without Informed Consent: a Narrative Review.
Flory JH, et al. J Gen Intern Med 2016 - Review. PMID 27384536 Free PMC article.
BACKGROUND: Individual informed consent from all participants is required for most randomized clinical trials (RCTs). However, some exceptions-for example, emergency research-are widely accepted. ...RESULTS: We identified ten different proposals for RWOC: two variants of cluster randomization, two variants of the Zelen design, consent to postponed information, two-stage randomized consent, cohort multiple RCT, emergency research, prompted optional randomization trials, and low-risk pragmatic RCTs without consent. ...
BACKGROUND: Individual informed consent from all participants is required for most randomized clinical trials (RCTs). However, …
Challenges in randomized controlled trials and emerging multiple sclerosis therapeutics.
Huang D. Neurosci Bull 2015 - Review. PMID 26480875 Free PMC article.
The use of an active comparator control group increases the number of participants in each group that is essential to achieve statistical significance, thus further increasing the difficulty of completing randomized controlled trials (RCTs) for the development of new MS therapies. ...Lack of access to approved DMTs provides a good opportunity for clinical trials that are designed for the development of new MS therapies. ...
The use of an active comparator control group increases the number of participants in each group that is essential to achieve statistical si …
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