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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 2
1989 16
1990 77
1991 76
1992 45
1993 52
1994 67
1995 72
1996 106
1997 98
1998 115
1999 128
2000 161
2001 204
2002 256
2003 299
2004 286
2005 367
2006 425
2007 428
2008 433
2009 517
2010 553
2011 655
2012 671
2013 764
2014 731
2015 708
2016 673
2017 713
2018 679
2019 264
2020 3
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9,549 results
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Page 1
A simplified guide to randomized controlled trials.
Bhide A, et al. Acta Obstet Gynecol Scand 2018 - Review. PMID 29377058
Therefore, randomized controlled trials are becoming increasingly popular in all areas of clinical medicine including perinatology. ...In this review, we provide simple descriptive guidance on planning, conducting, analyzing and reporting randomized controlled trials....
Therefore, randomized controlled trials are becoming increasingly popular in all areas of clinical medicine including p …
Pragmatic Trials.
Ford I and Norrie J. N Engl J Med 2016. PMID 27518663 Free article.
Eliminating bias in randomized controlled trials: importance of allocation concealment and masking.
Viera AJ and Bangdiwala SI. Fam Med 2007. PMID 17273956 Free article.
Randomization in randomized controlled trials involves more than generation of a random sequence by which to assign subjects. ...In contrast to allocation concealment, masking cannot always be incorporated into a randomized controlled trial. Both allocation concealment and masking add to the elimination of bias in randomized controlled trials....
Randomization in randomized controlled trials involves more than generation of a random sequence by which to assign sub …
Evaluating Complex Health Interventions With Randomized Controlled Trials: How Do We Improve the Use of Qualitative Methods?
Mannell J and Davis K. Qual Health Res 2019. PMID 30871431
Qualitative methods are underutilized in health intervention evaluation, and overshadowed by the importance placed on randomized controlled trials (RCTs). This Commentary describes how innovative qualitative methods are being used as part of RCTs, drawing on articles included in a special issue of Qualitative Health Research on this topic. ...
Qualitative methods are underutilized in health intervention evaluation, and overshadowed by the importance placed on randomized
The Statistical Curriculum Within Randomized Controlled Trials in Critical Illness.
McCullough JPA, et al. Crit Care Med 2018. PMID 30119072
A total of 580 statistical tests or methods were identified within 116 original randomized controlled trials published between 2011 and 2015. ...CONCLUSIONS: Physicians assessing recent randomized controlled trials in critical illness encounter results derived from a substantial and potentially expanding range of biostatistical methods. ...
A total of 580 statistical tests or methods were identified within 116 original randomized controlled trials pub …
Nature as a Trialist?: Deconstructing the Analogy Between Mendelian Randomization and Randomized Trials.
Swanson SA, et al. Epidemiology 2017. PMID 28590373 Free PMC article.
For example, analytic practices that are discouraged in randomized trials should also be discouraged in MR studies. Here, we deconstruct the oft-made analogy between MR and randomized trials. ...By precisely defining the causal effects being estimated, we underscore that MR estimates are often vaguely analogous to per-protocol effects in randomized trials, and that current MR methods for estimating analogues of per-protocol effects could be biased in practice. ...
For example, analytic practices that are discouraged in randomized trials should also be discouraged in MR studies. Here, we d …
Odds ratio vs risk ratio in randomized controlled trials.
Balasubramanian H, et al. Postgrad Med 2015. PMID 25746068
OBJECTIVE: Use of odds ratio (OR) in randomized controlled trials (RCTs) has been criticized because it overestimates the effect size, if incorrectly interpreted as risk ratio (RR). ...METHODS: We reviewed 580 RCTs published in the New England Journal of Medicine between January 2004 and June 2014 and identified 107 RCTs that reported unadjusted RR (n = 76) or OR (n = 31) for the primary outcome. ...
OBJECTIVE: Use of odds ratio (OR) in randomized controlled trials (RCTs) has been criticized because it overestimates t …
Sham control methods used in ear-acupuncture/ear-acupressure randomized controlled trials: a systematic review.
Zhang CS, et al. J Altern Complement Med 2014 - Review. PMID 24138333 Free PMC article.
Ear-acupuncture/ear-acupressure (EAP) has been used for a range of health conditions with numerous randomized controlled trials (RCTs) investigating its efficacy and safety. ...Four types of sham methods were identified. Among the 55 RCTs, 25 studies involved treatment on nonspecific ear acupoints as the sham method; seven studies used nonacupoints on the ear; nine studies selected placebo needles or placebo ear-acupressure on the same ear acupoints for the real treatment; 10 studies employed pseudo-intervention; and five studies combined two of the above methods to be the sham control. ...
Ear-acupuncture/ear-acupressure (EAP) has been used for a range of health conditions with numerous randomized controlled tr
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