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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 4
1964 3
1965 1
1971 1
1972 1
1974 2
1981 1
1982 1
1983 16
1984 263
1985 491
1986 600
1987 624
1988 651
1989 633
1990 658
1991 715
1992 672
1993 662
1994 670
1995 767
1996 605
1997 601
1998 562
1999 509
2000 510
2001 478
2002 455
2003 466
2004 494
2005 474
2006 413
2007 477
2008 485
2009 460
2010 478
2011 489
2012 517
2013 495
2014 458
2015 450
2016 404
2017 389
2018 350
2019 181
2020 8
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17,680 results
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Page 1
The Quinpirole Hypolocomotive Effects are Strain and Route of Administration Dependent in SHR and SLA16 Isogenic Rats.
Pértile RAN, et al. Behav Genet 2017. PMID 28822047
The SHR and SLA16 inbred strains present behavioral differences in anxiety/emotionality that could be under the influence of dopaminergic neurotransmission. ...Quinpirole and haloperidol IP decreased locomotor activity, only in SLA16 rats in the open-field (OF), and in both strains in the elevated plus-maze (EPM). ...
The SHR and SLA16 inbred strains present behavioral differences in anxiety/emotionality that could be under the influence of dopamine …
Enhancement of central pressor effect of AVP in SHR and WKY rats by intracranial N(G)-nitro-L-arginine.
Paczwa P, et al. Brain Res 1997. PMID 9067444
The aim of the present study was to find out whether brain nitroxidergic system may be involved in modulation of central cardiovascular effects of arginine vasopressin (AVP) in normotensive (WKY) rats and whether its regulatory effects are altered in spontaneously hypertensive (SHR) rats. ...Effectiveness of this compensatory mechanism is enhanced in the SHR rats....
The aim of the present study was to find out whether brain nitroxidergic system may be involved in modulation of central cardiovascular effe …
Comparison of the validity of the use of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder in males and females
Bayless DW, et al. Behav Brain Res 2015. PMID 25724583
Analyses of the number of premature responses revealed that SHR rats made more inhibitory control errors than did control rats and that this decrease in inhibitory control was present in both SHR males and females. Analyses of activity in the open field revealed that SHR rats were more hyperactive than were control rats and that this increased hyperactivity was present in both SHR males and females. ...
Analyses of the number of premature responses revealed that SHR rats made more inhibitory control errors than did control rats
Major thermogenic defect associated with insulin resistance in brown adipose tissue of obese diabetic SHR/N-cp rats.
Marette A, et al. Am J Physiol 1991. PMID 1651655
The effects of norepinephrine and insulin on thermogenesis were investigated in adipocytes isolated from brown adipose tissue (BAT) of obese non-diabetic LA/N-cp rats (obese LA), obese diabetic SHR/N-cp rats (obese SHR), and their corresponding lean controls. ...In contrast, all the above biochemical parameters were normal in obese LA rats. These results demonstrate that the marked insulin resistance in BAT of obese SHR rats is associated with a decreased responsiveness and sensitivity to norepinephrine, indicating the presence of receptor and postreceptor defects. ...
The effects of norepinephrine and insulin on thermogenesis were investigated in adipocytes isolated from brown adipose tissue (BAT) of obese …
Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model
Šedová L, et al. PLoS One 2016. PMID 27031336 Free PMC article.
SHR.BN16 congenic rats had significantly lower weight, decreased concentrations of total triglycerides and cholesterol, and improved glucose tolerance compared with SHR rats. ...SHR.BN16 rats had significantly lower systolic (18-28 mmHg difference) and diastolic (10-15 mmHg difference) blood pressure throughout the experiment (repeated-measures ANOVA, P < 0.001). ...
SHR.BN16 congenic rats had significantly lower weight, decreased concentrations of total triglycerides and cholesterol, and improved …
Reprint of "Problems with spontaneously hypertensive rats (SHR) as a model of attention-deficit/hyperactivity disorder (AD/HD)".
Alsop B. J Neurosci Methods 2007 - Review. PMID 17980764
Spontaneously hypertensive rats (SHR) have been promoted as animal models of attention-deficit hyperactivity disorder (AD/HD). ...
Spontaneously hypertensive rats (SHR) have been promoted as animal models of attention-deficit hyperactivity disorder (AD/HD). ...
Decreased content in left atrium and increased plasma concentration of atrial natriuretic polypeptide in spontaneously hypertensive rats (SHR) and SHR stroke-prone.
Morii N, et al. Biochem Biophys Res Commun 1986. PMID 2937405
The atrial contents and concentrations, and the plasma concentrations of atrial natriuretic polypeptide (ANP) in spontaneously hypertensive rats (SHR) and SHR stroke-prone (SHRSP) were measured and compared with those of age-matched Wistar Kyoto rats (WKY) using a specific radioimmunoassay (RIA) for alpha-rat ANP (alpha-rANP). ...
The atrial contents and concentrations, and the plasma concentrations of atrial natriuretic polypeptide (ANP) in spontaneously hypertensive …
Vascular smooth muscle cells direct extracellular dysregulation in aortic stiffening of hypertensive rats.
Hays TT, et al. Aging Cell 2018. PMID 29603864 Free PMC article.
Aortic stiffening was confirmed in spontaneously hypertensive rats (SHRs) vs. Wistar-Kyoto (WKY) rats in vivo by echocardiography and ex vivo by isometric force measurements in isolated de-endothelized aortic vessel segments. ...
Aortic stiffening was confirmed in spontaneously hypertensive rats (SHRs) vs. Wistar-Kyoto (WKY) rats in vivo by echocardiogra …
Visual discrimination learning in spontaneously hypertensive (SHR) and Wistar normotensive rats: computerized analysis of choice strategies.
Niewiadomska G and Niewiadomski W. Acta Neurobiol Exp (Wars) 1995. PMID 7660861 Free article.
Spontaneously hypertensive rats (SHR) were found to learn a visual discrimination paradigm better than Wistar normotensive rats (NT). ...SHR solved the task using different strategies than the NT rats. All subjects began by responding to position as a cue, but SHR gave up this strategy more quickly than NT rats did and responded earlier to colour. ...
Spontaneously hypertensive rats (SHR) were found to learn a visual discrimination paradigm better than Wistar normotensive rats
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