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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1981 1
1983 12
1984 154
1985 292
1986 345
1987 399
1988 427
1989 421
1990 452
1991 554
1992 539
1993 563
1994 499
1995 623
1996 494
1997 509
1998 474
1999 449
2000 469
2001 429
2002 413
2003 410
2004 397
2005 387
2006 353
2007 380
2008 409
2009 385
2010 379
2011 384
2012 379
2013 327
2014 285
2015 341
2016 284
2017 272
2018 212
2019 102
2020 1
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13,438 results
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Page 1
Differential use of danger and safety signals in an animal model of anxiety vulnerability: The behavioral economics of avoidance
Spiegler KM, et al. Prog Neuropsychopharmacol Biol Psychiatry 2018. PMID 29175308
Hedonic value of avoidance did not differ between SD and WKY rats, but WKY rats had greater motivation to avoid than SD rats. ...When danger and safety signals were presented simultaneously, WKY rats responded to the danger signals, whereas SD rats responded to the safety signal. ...
Hedonic value of avoidance did not differ between SD and WKY rats, but WKY rats had greater motivation to avoid than SD rat
The performance of WKY rats on three tests of emotional behavior.
Paré WP. Physiol Behav 1992. PMID 1615043
Scores reflecting anxiety in the elevated plus maze were lowest for Fischer-344 rats and highest for WKY rats, but the anxiety scores of WKY rats did not differ significantly from Wistar rats. ...We propose that WKY rats are hyperresponsive to stress and that novelty stress elicits depression-like behavior, which is the prevalent behavioral stress response in WKY rats....
Scores reflecting anxiety in the elevated plus maze were lowest for Fischer-344 rats and highest for WKY rats, but the anxiety …
[Effect of glucocorticoid receptor function on the behavior of rats with attention deficit hyperactivity disorder].
Lu HZ, et al. Zhongguo Dang Dai Er Ke Za Zhi 2018. PMID 30369362 Chinese. Free article.
OBJECTIVE: To investigate the ideal animal models for attention deficit hyperactivity disorder (ADHD) subtypes and the effect of glucocorticoid receptor (GR) function on the behavior of ADHD rats by comparing behavioral differences between spontaneously hypertensive rats (SHRs), Wistar Kyoto (WKY) rats, and Sprague-Dawley (SD) rats. METHODS: A total of 24 male SHRs aged 21 days were randomly divided into GR agonist group, GR inhibitor group, and SHR group, with 8 rats in each group. ...
OBJECTIVE: To investigate the ideal animal models for attention deficit hyperactivity disorder (ADHD) subtypes and the effect of glucocortic …
Substrain comparison of genetically hypertensive rats using DNA fingerprinting, and genetic analysis of blood pressure in the inbred rats.
Katsuya T, et al. Tohoku J Exp Med 1991. PMID 1818433 Free article.
Using DNA fingerprinting, genetic heterogeneity or homogeneity was studied between substrains of spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats maintained in Japan. ...In another experiment using the inbred substrains of SHR and WKY rats which have been confirmed as genetically homogeneous, we produced F1 and F2 rats, and biometrically analyzed their systolic blood pressure. ...
Using DNA fingerprinting, genetic heterogeneity or homogeneity was studied between substrains of spontaneously hypertensive rats (SHR …
[Effects of ketamine, imipramine, and their combination on depression-like behaviors in Wistar Kyoto rats].
Ye K, et al. Sheng Li Xue Bao 2016. PMID 26915317 Chinese. Free article.
The results showed that, compared with Wistar rats, WKY rats exhibited decreased sucrose preference and extended immobility time. ...Compared with Wistar rats, WKY rats showed up-regulated levels of βCaMKII and membrane GluR1 protein expressions in habenula, and down-regulated level of membrane GluR1 protein expressions in the prefrontal cortex. ...
The results showed that, compared with Wistar rats, WKY rats exhibited decreased sucrose preference and extended immobility ti …
Differences in the stress response of Wistar-Kyoto (WKY) rats from different vendors.
Paré WP and Kluczynski J. Physiol Behav 1997. PMID 9272677
Wistar-Kyoto (WKY) rats are hyperresponsive to stress and prone to stress ulcer. However, some variability in these general findings has been reported. ...WKY-CR and WKY-H rats revealed significantly more ulcers as compared to WKY-T and Wistar rats. The WKY inbreeding programs at Charles River and Harlan, as compared to the outbreeding practice at Taconic may contribute to these vendor differences. ...
Wistar-Kyoto (WKY) rats are hyperresponsive to stress and prone to stress ulcer. However, some variability in these general findings …
Differences in free amino acid concentrations in milk between Wistar and Wistar Kyoto rats.
Hamada M, et al. J Vet Med Sci 2019. PMID 30982807 Free PMC article.
Wistar Kyoto (WKY) rats, an animal depression model, display abnormal behaviors such as hypoactivity and depression-like behavior compared with Wistar (WIS) rats as a control. A previous study confirmed a dysfunction of amino acid metabolism in the brain of WKY rats compared with that of WIS rats. At the neonatal stage, free amino acids in milk are important nutrients because they act as immediate nutrients for offspring and may affect later health and behavior of the offspring. ...
Wistar Kyoto (WKY) rats, an animal depression model, display abnormal behaviors such as hypoactivity and depression-like behavior com …
Amplified cardiorespiratory activity by hypoxia in conscious spontaneously hypertensive rats.
Tian YM, et al. Sheng Li Xue Bao 2019. PMID 31440747 Free article.
We found that exposure to hypoxia induced greater increases in tidal volume and minute ventilation volume in SHRs compared to WKY rats. ...After carotid body denervation, the hypoxic ventilatory response was significantly decreased in both SHRs and WKY rats, but without significant difference between the two strains; moreover, the differences of arterial blood pressure and heart rate changes during hypoxic exposure were statistically insignificant between SHRs and WKY rats. ...
We found that exposure to hypoxia induced greater increases in tidal volume and minute ventilation volume in SHRs compared to WKY rats
Long-term left ventricular echocardiographic follow-up of SHR and WKY rats: effects of hypertension and age.
Slama M, et al. Am J Physiol Heart Circ Physiol 2004. PMID 12958037 Free article.
No difference in LVEDD was found between SHR and WKY rats; however, LVEDD was increased at 80 wk in both strains. SF decreased slightly in old WKY rats. ...VE/VA and Em/Am decreased at 80 wk in WKY rats. LV relaxation (IVRT, Tei index, and Vp) was progressively impaired in SHR compared with WKY rats. ...
No difference in LVEDD was found between SHR and WKY rats; however, LVEDD was increased at 80 wk in both strains. SF decreased slight …
13,438 results
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