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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1985 1
1986 1
1988 4
1989 9
1990 13
1991 42
1992 50
1993 231
1994 641
1995 688
1996 775
1997 823
1998 902
1999 898
2000 840
2001 966
2002 886
2003 700
2004 679
2005 593
2006 365
2007 394
2008 403
2009 378
2010 516
2011 642
2012 682
2013 786
2014 815
2015 860
2016 835
2017 746
2018 450
2019 180
2020 5
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16,737 results
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Page 1
Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges.
Butti R, et al. Mol Cancer 2018 - Review. PMID 29455658 Free PMC article.
Receptor Tyrosine Kinases (RTKs) constitute a class of receptors that play important role in cancer progression. RTKs are cell surface receptors with specialized structural and biological features which respond to environmental cues by initiating appropriate signaling cascades in tumor cells. ...
Receptor Tyrosine Kinases (RTKs) constitute a class of receptors that play important role in cancer progression. RTKs a
Blurring Boundaries: Receptor Tyrosine Kinases as functional G Protein-Coupled Receptors.
Crudden C, et al. Int Rev Cell Mol Biol 2018 - Review. PMID 29776602
Receptor tyrosine kinases (RTKs) such as the insulin-like growth factor type 1 receptor (IGF-1R) control important biological activities as well as being involved in pathological processes. ...In addition, substantial evidence exists that the IGF-1R and other RTKs make direct use of the G protein-coupled receptor (GPCR) components G proteins, GRKs, and β-arrestins, outside of their traditional receptor family frame. ...
Receptor tyrosine kinases (RTKs) such as the insulin-like growth factor type 1 receptor (IGF-1R) control importa
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.
Jin N, et al. Nat Commun 2019. PMID 31221965 Free PMC article.
Establishing the link between metabolic signatures and the oncogenic alterations of receptor tyrosine kinases (RTK), the most well-defined cancer genotypes, may precisely direct metabolic intervention to a broad patient population. ...
Establishing the link between metabolic signatures and the oncogenic alterations of receptor tyrosine kinases (RTK), th …
Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children
Drilon A, et al. N Engl J Med 2018 - Clinical Trial. PMID 29466156 Free PMC article.
BACKGROUND: Fusions involving one of three tropomyosin receptor kinases (TRK) occur in diverse cancers in children and adults. ...
BACKGROUND: Fusions involving one of three tropomyosin receptor kinases (TRK) occur in diverse cancers in children and adults. …
The biochemistry, signalling and disease relevance of RYK and other WNT-binding receptor tyrosine kinases.
Roy JP, et al. Growth Factors 2018 - Review. PMID 29806777
The receptor tyrosine kinases (RTKs) are a well-characterized family of growth factor receptors that have central roles in human disease and are frequently therapeutically targeted. ...Alternative signalling mechanisms, including proteolytic cleavage and protein scaffolding functions, have been identified for these receptors. ...
The receptor tyrosine kinases (RTKs) are a well-characterized family of growth factor receptors that have central roles …
Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma.
Qazi MA, et al. Cancer Res 2018. PMID 29945963 Free article.
Many members of the Eph receptor tyrosine kinase (EphR) family are expressed by GBM stem cells (GSC), which have been implicated in resistance to GBM therapy. ...
Many members of the Eph receptor tyrosine kinase (EphR) family are expressed by GBM stem cells (GSC), which have been implicat …
Anti-Inflammatory Role of TAM Family of Receptor Tyrosine Kinases Via Modulating Macrophage Function.
Lee CH and Chun T. Mol Cells 2019 - Review. PMID 30699285 Free PMC article.
Tyro3, Axl, and Mer are integral membrane proteins that constitute TAM family of receptor tyrosine kinases (RTKs). Growing evidence indicates that TAM family receptors play an important role in anti-inflammatory responses through modulating the function of macrophages. ...
Tyro3, Axl, and Mer are integral membrane proteins that constitute TAM family of receptor tyrosine kinases (RTKs). Grow …
Irreversible modifications of receptor tyrosine kinases.
Kreitman M, et al. FEBS Lett 2018 - Review. PMID 29790151 Free article.
Each group of the 56 receptor tyrosine kinases (RTK) binds with one or more soluble growth factors and coordinates a vast array of cellular functions. These outcomes are tightly regulated by inducible post-translational events, such as tyrosine phosphorylation, ubiquitination, ectodomain shedding, and regulated intramembrane proteolysis. ...
Each group of the 56 receptor tyrosine kinases (RTK) binds with one or more soluble growth factors and coordinates a va …
Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma
Abou-Alfa GK, et al. N Engl J Med 2018 - Clinical Trial. PMID 29972759 Free article.
BACKGROUND: Cabozantinib inhibits tyrosine kinases, including vascular endothelial growth factor receptors 1, 2, and 3, MET, and AXL, which are implicated in the progression of hepatocellular carcinoma and the development of resistance to sorafenib, the standard initial treatment for advanced disease. ...
BACKGROUND: Cabozantinib inhibits tyrosine kinases, including vascular endothelial growth factor receptors 1, 2, and 3, MET, a …
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