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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 61
2004 135
2005 180
2006 246
2007 296
2008 339
2009 343
2010 425
2011 405
2012 397
2013 398
2014 414
2015 396
2016 396
2017 408
2018 336
2019 150
2020 4
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4,529 results
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Cannabinoid receptors: where they are and what they do.
Mackie K. J Neuroendocrinol 2008 - Review. PMID 18426493
The endocannabinoid system consists of the endogenous cannabinoids (endocannabinoids), cannabinoid receptors and the enzymes that synthesise and degrade endocannabinoids. Many of the effects of cannabinoids and endocannabinoids are mediated by two G protein-coupled receptors (GPCRs), CB(1) and CB(2), although additional receptors may be involved. ...
The endocannabinoid system consists of the endogenous cannabinoids (endocannabinoids), cannabinoid receptors and the en …
From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology.
Ligresti A, et al. Physiol Rev 2016 - Review. PMID 27630175 Free article.
Apart from having been used and misused for at least four millennia for, among others, recreational and medicinal purposes, the cannabis plant and its most peculiar chemical components, the plant cannabinoids (phytocannabinoids), have the merit to have led humanity to discover one of the most intriguing and pleiotropic endogenous signaling systems, the endocannabinoid system (ECS). ...
Apart from having been used and misused for at least four millennia for, among others, recreational and medicinal purposes, the cannabis pla …
CB1 and CB2 Receptor Pharmacology
Howlett AC and Abood ME. Adv Pharmacol 2017 - Review. PMID 28826534 Free PMC article.
The CB(1) and CB(2) cannabinoid receptors (CB(1)R, CB(2)R) are members of the G protein-coupled receptor (GPCR) family that were identified over 20 years ago. ...Both receptors recognize multiple classes of agonist and antagonist compounds and produce an array of distinct downstream effects. ...
The CB(1) and CB(2) cannabinoid receptors (CB(1)R, CB(2)R) are members of the G protein-coupled receptor (GPCR) family that we …
The Role of Cannabinoid Receptors in Renal Diseases.
Francois H and Lecru L. Curr Med Chem 2018 - Review. PMID 28901271
The cannabinoid system and more specifically the cannabinoid receptors 1 (CB1) and 2 (CB2) may represent a new therapeutic target in CKD. ...CONCLUSION: Overall, we found that the cannabinoid receptors are a promising target in the development of renal disease and fibrosis, particularly in CKD and diabetes....
The cannabinoid system and more specifically the cannabinoid receptors 1 (CB1) and 2 (CB2) may represent a new therapeu …
Actions and Regulation of Ionotropic Cannabinoid Receptors.
De Petrocellis L, et al. Adv Pharmacol 2017 - Review. PMID 28826537
Almost three decades have passed since the identification of the two specific metabotropic receptors mediating cannabinoid pharmacology. Thereafter, many cannabinoid effects, both at central and peripheral levels, have been well documented and characterized. However, numerous evidences demonstrated that these pharmacological actions could not be attributable solely to the activation of CB1 and CB2 receptors since several important cannabimimetic actions have been found in biological systems lacking CB1 or CB2 gene such as in specific cell lines or transgenic mice. ...
Almost three decades have passed since the identification of the two specific metabotropic receptors mediating cannabinoid pha …
The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids.
McAllister SD, et al. J Neuroimmune Pharmacol 2015 - Review. PMID 25916739 Free PMC article.
In addition to THC, there are many other cannabinoids found in CS, and a majority produces little to no psychoactivity due to the inability to activate cannabinoid receptors. ...This review will center on mechanisms by which CBD, and other plant-derived cannabinoids inefficient at activating cannabinoid receptors, inhibit tumor cell viability, invasion, metastasis, angiogenesis, and the stem-like potential of cancer cells. ...
In addition to THC, there are many other cannabinoids found in CS, and a majority produces little to no psychoactivity due to the ina …
Localization of cannabinoid receptors CB1, CB2, GPR55, and PPARα in the canine gastrointestinal tract.
Galiazzo G, et al. Histochem Cell Biol 2018. PMID 29882158
The endocannabinoid system (ECS) is composed of cannabinoid receptors, their endogenous ligands, and the enzymes involved in endocannabinoid turnover. ...A growing body of evidence indicates that activation of cannabinoid receptors by endogenous, plant-derived, or synthetic cannabinoids may exert beneficial effects on gastrointestinal inflammation and visceral pain. ...
The endocannabinoid system (ECS) is composed of cannabinoid receptors, their endogenous ligands, and the enzymes involved in e …
Functional Selectivity at Cannabinoid Receptors.
Priestley R, et al. Adv Pharmacol 2017 - Review. PMID 28826535
For example, the classical cannabinoid HU-210 produces maximal activation of both G(i) and G(o) proteins, while the endocannabinoid anandamide and aminoalkylindole WIN 55,212 both produce maximal activation of G(i), but submaximal activation of G(o). Cannabinoid agonists can also signal differentially via β-arrestins coupled to mitogen-activated protein kinases, subsequently promoting varying degrees of receptor internalization and agonist desensitization. ...
For example, the classical cannabinoid HU-210 produces maximal activation of both G(i) and G(o) proteins, while the endocannabinoid a …
Endocannabinoids and Their Pharmacological Actions
Pertwee RG. Handb Exp Pharmacol 2015 - Review. PMID 26408156
The endocannabinoid system consists of G protein-coupled cannabinoid CB(1) and CB(2) receptors, of endogenous compounds known as endocannabinoids that can target these receptors, of enzymes that catalyse endocannabinoid biosynthesis and metabolism, and of processes responsible for the cellular uptake of some endocannabinoids. ...Also discussed are current in vitro data that indicate the extent to which some established or putative orthosteric endocannabinoids seem to target non-cannabinoid receptors and ion channels, particularly at concentrations at which they have been found to interact with CB(1) or CB(2) receptors....
The endocannabinoid system consists of G protein-coupled cannabinoid CB(1) and CB(2) receptors, of endogenous compounds known …
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