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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 4
1978 22
1979 19
1980 45
1981 56
1982 142
1983 136
1984 233
1985 321
1986 558
1987 744
1988 928
1989 1297
1990 1780
1991 2267
1992 2810
1993 3227
1994 3686
1995 4315
1996 4567
1997 5100
1998 5993
1999 6731
2000 7495
2001 7769
2002 7762
2003 8319
2004 8846
2005 9772
2006 10949
2007 11465
2008 12159
2009 13196
2010 13949
2011 14865
2012 15894
2013 16937
2014 16382
2015 16369
2016 15348
2017 14953
2018 13480
2019 5675
2020 85
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259,422 results
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Page 1
Beyond the Flavour: The Potential Druggability of Chemosensory G Protein-Coupled Receptors.
Di Pizio A, et al. Int J Mol Sci 2019 - Review. PMID 30897734 Free PMC article.
G protein-coupled receptors (GPCRs) belong to the largest class of drug targets. Approximately half of the members of the human GPCR superfamily are chemosensory receptors, including odorant receptors (ORs), trace amine-associated receptors (TAARs), bitter taste receptors (TAS2Rs), sweet and umami taste receptors (TAS1Rs). ...
G protein-coupled receptors (GPCRs) belong to the largest class of drug targets. Approximately half of the members of the human GPCR …
Fibroblast growth factor receptors in breast cancer.
Wang S and Ding Z. Tumour Biol 2017 - Review. PMID 28459213
First, we summarized the structure and physiological function of fibroblast growth factor receptors in humans. Then, we discussed the common genetic variations in fibroblast growth factor receptors that affect breast cancer risk. In addition, we also introduced the potential roles of each fibroblast growth factor receptors isoform in breast cancer. Finally, we explored the potential therapeutics targeting fibroblast growth factor receptors for breast cancer. ...
First, we summarized the structure and physiological function of fibroblast growth factor receptors in humans. Then, we discussed the …
New mutations and an updated database for the patched-1 (PTCH1) gene
Reinders MG, et al. Mol Genet Genomic Med 2018. PMID 29575684 Free PMC article.
BACKGROUND: Basal cell nevus syndrome (BCNS) is an autosomal dominant disorder characterized by multiple basal cell carcinomas (BCCs), maxillary keratocysts, and cerebral calcifications. ...
BACKGROUND: Basal cell nevus syndrome (BCNS) is an autosomal dominant disorder characterized by multiple basal cell carcinomas …
CGRP Receptor Signalling Pathways
Cottrell GS. Handb Exp Pharmacol 2019. PMID 30151722
It is now also clear that in addition to the initiation of cell-surface signalling, GPCRs, including the CGRP receptor, also activate distinct signalling pathways as the receptor is trafficking along the endocytic conduit.Given CGRP's characteristic of activating multiple GPCRs, we will first consider the complex of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) as the CGRP receptor. We will discuss the discovery of the CGRP receptor components, the molecular mechanisms controlling its internalization and post-endocytic trafficking (recycling and degradation) and the diverse signalling cascades that are elicited by this receptor in model cell lines. ...
It is now also clear that in addition to the initiation of cell-surface signalling, GPCRs, including the CGRP receptor, also a …
Interplay of Endocytosis and Growth Factor Receptor Signalling
Moore R, et al. Prog Mol Subcell Biol 2018 - Review. PMID 30097776
The original paradigm for the role of endocytosis in growth factor receptor signalling was that receptor uptake has a quantitative role in signalling by reducing the number of cell surface receptors available for activation and targeting activated receptors for degradation. ...Therefore, endocytosis does not simply regulate cell surface expression, but tightly controls protein interactions and function to produce distinct outcomes....
The original paradigm for the role of endocytosis in growth factor receptor signalling was that receptor uptake has a quantitative role in s …
Neurotrophic tropomyosin or tyrosine receptor kinase (NTRK) genes
Chetty R. J Clin Pathol 2019 - Review. PMID 30636697
Immunohistochemical localisation of the fusion protein to the nucleus, cytoplasm, nuclear membrane and cell membrane is indicative of specific gene fusions involving the NTRK genes....
Immunohistochemical localisation of the fusion protein to the nucleus, cytoplasm, nuclear membrane and cell membrane is indicative of …
Dominant negative mutants: tools for the study of protein function in vitro and in vivo
Sheppard D. Am J Respir Cell Mol Biol 1994 - Review. PMID 8018332
Dominant negative mutants have already provided insights into the molecular mechanisms of action of a number of protein families, including hormone receptors, oncogenes, and growth factor receptors, and have been identified as the cause of at least a few autosomal dominant diseases. Expression of dominant negative mutants under the control of highly active lung cell-specific promoters holds great promise for the study of the roles specific proteins and protein families play in lung development, health, and disease....
Dominant negative mutants have already provided insights into the molecular mechanisms of action of a number of protein families, including …
Chemosensory receptor specificity and regulation
Dalton RP and Lomvardas S. Annu Rev Neurosci 2015 - Review. PMID 25938729 Free PMC article.
Stimulus sensitivity is due to expression of different cell surface sensory receptors, and therefore the receptive field of each sense is defined by the aggregate of expressed receptors in each sensory tissue. Here, we review current understanding on patterns of expression and modes of regulation of sensory receptors....
Stimulus sensitivity is due to expression of different cell surface sensory receptors, and therefore the receptive fiel …
Exploiting antigen receptor information to quantify index switching in single-cell transcriptome sequencing experiments.
Yao Y, et al. PLoS One 2018. PMID 30517183 Free PMC article.
We took advantage of the diverse but highly cell-specific expression of antigen receptors on immune cells to quantify index switching on single cell RNA-seq data that were sequenced on HiSeq 3000 and HiSeq 4000. ...Based on full-length T cell receptor (TCR) sequences from all samples reconstructed by TraCeR and TCR gene expression quantified by Kallisto, we found index switching in all three batches of experiments investigated. ...
We took advantage of the diverse but highly cell-specific expression of antigen receptors on immune cells to quantify index sw …
259,422 results
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