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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 6
1968 1
1970 1
1971 3
1972 3
1973 5
1974 31
1975 76
1976 275
1977 767
1978 1017
1979 1312
1980 1835
1981 2104
1982 2428
1983 2749
1984 3298
1985 3381
1986 3832
1987 4011
1988 4621
1989 5009
1990 5820
1991 6070
1992 6646
1993 7638
1994 8429
1995 8905
1996 9547
1997 10324
1998 10672
1999 11314
2000 12666
2001 13929
2002 14665
2003 16162
2004 17186
2005 17977
2006 19599
2007 20842
2008 22701
2009 24115
2010 25338
2011 27716
2012 28778
2013 30043
2014 28701
2015 27883
2016 26937
2017 25913
2018 23726
2019 10189
2020 185
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508,110 results
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Page 1
Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways.
Futosi K, et al. Int Immunopharmacol 2013 - Review. PMID 24263067
Neutrophils express a large number of cell surface receptors for the recognition of pathogen invasion and the inflammatory environment. ...The various cell surface receptors trigger very diverse signal transduction pathways including activation of heterotrimeric and monomeric G-proteins, receptor-induced and store-operated Ca(2+) signals, protein and lipid kinases, adapter proteins and cytoskeletal rearrangement. ...
Neutrophils express a large number of cell surface receptors for the recognition of pathogen invasion and the inflammat …
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Anderson AC, et al. Immunity 2016 - Review. PMID 27192565 Free PMC article.
Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T cell responses and have proven to be effective targets in the setting of chronic diseases where constitutive co-inhibitory receptor expression on T cells dampens effector T cell responses. ...Increased understanding of the specialized functions of these receptors will inform the rational application of therapies that target these receptors to the clinic....
Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T cell responses and have proven to be …
Cell-surface receptors transactivation mediated by g protein-coupled receptors.
Cattaneo F, et al. Int J Mol Sci 2014 - Review. PMID 25356505 Free PMC article.
G protein-coupled receptors (GPCRs) are seven transmembrane-spanning proteins belonging to a large family of cell-surface receptors involved in many intracellular signaling cascades. ...Herein, we discuss the main mechanisms of GPCR-mediated cell-surface receptors transactivation and the pathways involved in intracellular responses induced by GPCR agonists. ...
G protein-coupled receptors (GPCRs) are seven transmembrane-spanning proteins belonging to a large family of cell-surface
Signals and Receptors.
Heldin CH, et al. Cold Spring Harb Perspect Biol 2016 - Review. PMID 27037414 Free PMC article.
Communication between cells in a multicellular organism occurs by the production of ligands (proteins, peptides, fatty acids, steroids, gases, and other low-molecular-weight compounds) that are either secreted by cells or presented on their surface, and act on receptors on, or in, other target cells. Such signals control cell growth, migration, survival, and differentiation. Signaling receptors can be single-span plasma membrane receptors associated with tyrosine or serine/threonine kinase activities, proteins with seven transmembrane domains, or intracellular receptors. ...
Communication between cells in a multicellular organism occurs by the production of ligands (proteins, peptides, fatty acids, steroids, gase …
Cell-Surface Receptor-Ligand Interaction Analysis with Homogeneous Time-Resolved FRET and Metabolic Glycan Engineering: Application to Transmembrane and GPI-Anchored Receptors.
Stockmann H, et al. J Am Chem Soc 2017. PMID 29068676
Cell-surface receptors and their ligands have traditionally been characterized by radioligand-binding assays, which have low temporal and spatial resolution and entail safety risks. ...Given that all cell-surface receptors are glycosylated, we expect that GlycoFRET can be generalized with applications in chemical biology and biotechnology, such as target engagement, receptor pharmacology, and high-throughput screening....
Cell-surface receptors and their ligands have traditionally been characterized by radioligand-binding assays, which hav
Evolution of the Muscarinic Acetylcholine Receptors in Vertebrates.
Pedersen JE, et al. eNeuro 2018. PMID 30564629 Free PMC article.
The family of muscarinic acetylcholine receptors (mAChRs) consists of five members in mammals, encoded by the CHRM1-5 genes. The mAChRs are G-protein-coupled receptors, which can be divided into the following two subfamilies: M2 and M4 receptors coupling to G(i/o); and M1, M3, and M5 receptors coupling to G(q/11). ...
The family of muscarinic acetylcholine receptors (mAChRs) consists of five members in mammals, encoded by the CHRM1-5 genes. The mACh …
Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors.
Leytin V, et al. Clin Appl Thromb Hemost 2019 - Review. PMID 31167567 Free PMC article.
In nucleated cells, the extrinsic pathway of the programmed cell death (apoptosis) is triggered by interaction of death ligands of the tumor necrosis factor superfamily with the death receptors on external cell surface membrane. ...These platelet surface receptors include the protease-activated receptor 1 of thrombin and glycoproteins IIbIIIa and Ibα, receptors of fibrinogen, and von Willebrand factor. ...
In nucleated cells, the extrinsic pathway of the programmed cell death (apoptosis) is triggered by interaction of death ligands of th …
Multiple aberrant hormone receptors in Cushing's syndrome.
El Ghorayeb N, et al. Eur J Endocrinol 2015 - Review. PMID 25971648
Aberrant hormone receptors can also exert their activity by regulating the paracrine secretion of ACTH or other ligands for those receptors in BMAH or unilateral tumors. ...Targeted therapies to block the aberrant receptors or their ligands could become useful in the future....
Aberrant hormone receptors can also exert their activity by regulating the paracrine secretion of ACTH or other ligands for those …
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