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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 3
1981 23
1982 14
1983 27
1984 38
1985 49
1986 49
1987 66
1988 69
1989 98
1990 97
1991 134
1992 156
1993 173
1994 269
1995 156
1996 195
1997 206
1998 160
1999 176
2000 124
2001 126
2002 144
2003 99
2004 41
2005 43
2006 40
2007 44
2008 33
2009 24
2010 29
2011 29
2012 36
2013 26
2014 16
2015 12
2016 12
2017 13
2018 8
2019 3
2020 0
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2,990 results
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Page 1
Cholecystokinin and gastrin receptors.
Dufresne M, et al. Physiol Rev 2006 - Review. PMID 16816139 Free article.
Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled receptors that have been the subject of intensive research in the last 10 years with corresponding advances in the understanding of their functioning and physiology. ...We then focus on peripheral cholecystokinin receptors by describing their tissue distribution and physiological actions. Finally, pathophysiological peripheral actions of cholecystokinin receptors and their relevance in clinical disorders are reviewed....
Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled receptors that have been the subject of i
Cholecystokinin and gastrin receptors targeting in gastrointestinal cancer.
Rai R, et al. Surg Oncol 2012 - Review. PMID 22801592
Cholecystokinin and Gastrin are amongst the first gastrointestinal hormone discovered. In addition to classical actions (contraction of gallbladder, growth and secretion in the stomach and pancreas), these also act as growth stimulants for gastrointestinal malignancies and cell lines. Growth of these tumours is inhibited by antagonists of the cholecystokinin and gastrin receptors. These receptors provides most promising approach in clinical oncology and several specific radiolabelled ligands have been synthesized for specific tumour targeting and therapy of tumours overexpressing these receptors. ...
Cholecystokinin and Gastrin are amongst the first gastrointestinal hormone discovered. In addition to classical actions (contraction
Cholecystokinin receptors regulate sperm protein tyrosine phosphorylation via uptake of HCO3-.
Zhou Y, et al. Reproduction 2015. PMID 26175429
Cholecystokinin (CCK), a peptide hormone and a neurotransmitter, was detected in mature sperm two decades ago. However, the exact role of CCK and the types of CCK receptors (now termed CCK1 and CCK2) in sperm have not been identified. ...Interestingly, the synthetic octapeptide of CCK (CCK8) showed the same action and mechanism as antagonists of CCK receptors. ...
Cholecystokinin (CCK), a peptide hormone and a neurotransmitter, was detected in mature sperm two decades ago. However, the exact rol
Expression of cholecystokinin, gastrin, and their receptors in the mouse cornea.
Gonzalez-Coto AF, et al. Invest Ophthalmol Vis Sci 2014. PMID 24576871
PURPOSE: Cholecystokinin (CCK) is a neuropeptide that has been identified in trigeminal ganglion neurons. Gastrin (GAST) is a related peptide never explored in the cornea. ...We explored here in mice whether CCK, GAST, and their receptors CCK1R and CCK2R are expressed in the corneal epithelium and trigeminal ganglion neurons innervating the cornea. ...
PURPOSE: Cholecystokinin (CCK) is a neuropeptide that has been identified in trigeminal ganglion neurons. Gastrin (GAST) is a related …
Cholecystokinin Switches the Plasticity of GABA Synapses in the Dorsomedial Hypothalamus via Astrocytic ATP Release.
Crosby KM, et al. J Neurosci 2018. PMID 30108130 Free PMC article.
This LTP requires the activation of both type 2 CCK receptors and group 5 metabotropic glutamate receptors, resulting in a rise in astrocytic intracellular calcium and subsequent ATP release. ATP then acts on presynaptic P2X receptors to trigger a prolonged increase in GABA release. Our observations demonstrate a novel form of CCK-mediated plasticity that requires astrocytic ATP release, and could serve as a mechanism for appetite regulation.SIGNIFICANCE STATEMENT Satiety peptides, like cholecystokinin, play an important role in the central regulation of appetite, but their effect on synaptic plasticity is not well understood. ...
This LTP requires the activation of both type 2 CCK receptors and group 5 metabotropic glutamate receptors, resulting in a ris …
The role of cholecystokinin receptors in the short-term control of food intake.
Sayegh AI. Prog Mol Biol Transl Sci 2013 - Review. PMID 23317788
Cholecystokinin (CCK) is a hormone secreted by the I-cells of the upper small intestine in response to fat, protein, and some nonnutrients, for example, camostat, and a peptide/neurotransmitter secreted by neurons of the central and peripheral nervous systems. ...CCK evokes these responses by activating two G protein-coupled receptors: CCK(1) and CCK(2). CCK(1) receptors are located mainly in the alimentary tract and contain two affinity states, high and low, whereas CCK(2) receptors are found mainly in the brain. ...
Cholecystokinin (CCK) is a hormone secreted by the I-cells of the upper small intestine in response to fat, protein, and some nonnutr
Activation of galanin and cholecystokinin receptors in the lumbosacral spinal cord is required for ejaculation in male rats.
Kozyrev N and Coolen LM. Eur J Neurosci 2017. PMID 28002640 Free article.
Here, the role of two other neuropeptides co-expressed in LSt cells for ejaculatory reflexes is demonstrated: galanin and cholecystokinin (CCK). ...
Here, the role of two other neuropeptides co-expressed in LSt cells for ejaculatory reflexes is demonstrated: galanin and cholecystokinin
Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats.
DeSantana JM, et al. Pain 2010. PMID 19944533 Free PMC article.
Prior pharmacological studies show that blockade of cholecystokinin (CCK) receptors systemically and spinally prevents the development of analgesic tolerance to repeated doses of opioid agonists. ...In the same animals we show that spinal blockade of CCK-A receptors prevents cross-tolerance at spinal delta-opioid receptors that normally occurs with high frequency TENS; and blockade of CCK-B receptors prevents cross-tolerance at spinal mu-opioid receptors that normally occurs with low frequency TENS. ...
Prior pharmacological studies show that blockade of cholecystokinin (CCK) receptors systemically and spinally prevents the dev …
Contribution of CCK1 receptors to cardiovascular and respiratory effects of cholecystokinin in anesthetized rats.
Kaczyńska K and Szereda-Przestaszewska M. Neuropeptides 2015. PMID 26342277
The study investigated the share of vagal input at infra- and supra-nodosal level and the contribution of CCK1 and CCK2 receptors to the cardiorespiratory responses produced by an intravenous injection of sulfated cholecystokinin octapeptide (CCK-8) in anesthetized rats. ...All cardiovascular and respiratory effects were antagonized by pre-treatment with devazepide-CCK1 receptors' antagonist, whereas CI988-antagonist of CCK2 receptors was ineffective. ...
The study investigated the share of vagal input at infra- and supra-nodosal level and the contribution of CCK1 and CCK2 receptors to …
Insights into the binding and activation sites of the receptors for cholecystokinin and gastrin.
Foucaud M, et al. Regul Pept 2008 - Review. PMID 17961734
In the current paper, we report studies from our laboratory and others which have provided new data on the molecular basis of the pharmacology and functioning of CCK1 and CCK2 receptors. It has been shown that: 1) homologous regions of the two receptors are involved in the binding site of CCK, however, positioning of CCK slightly differs in agreement with distinct pharmacophores of CCK toward the two receptors and receptor sequence variations; 2) Binding sites of most of non-peptide agonists/ antagonist are buried in the pocket formed by transmembrane helices and overlap that of CCK; Aromatic amino acids within and near the binding site, especially in helix VI, are involved in receptor activation; 4) Like for other members of family A of G-protein coupled receptors, residues of the binding sites as well as of conserved motifs such as E/DRY, NPXXY are crucial for receptor activation....
In the current paper, we report studies from our laboratory and others which have provided new data on the molecular basis of the pharmacolo …
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