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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 2
1978 10
1979 7
1980 25
1981 25
1982 65
1983 45
1984 109
1985 192
1986 316
1987 431
1988 503
1989 632
1990 781
1991 951
1992 1102
1993 1253
1994 1340
1995 1634
1996 1776
1997 1974
1998 2263
1999 2546
2000 2906
2001 2979
2002 2877
2003 2912
2004 2986
2005 3475
2006 4100
2007 4439
2008 4608
2009 5002
2010 5282
2011 5775
2012 6118
2013 6579
2014 6545
2015 6428
2016 5892
2017 5739
2018 5065
2019 2194
2020 35
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99,584 results
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Page 1
Proteolytic control of Interleukin-11 and Interleukin-6 biology
Lokau J, et al. Biochim Biophys Acta Mol Cell Res 2017 - Review. PMID 28630024 Free article.
Activation of target cells occurs via membrane-bound IL-11 and IL-6 receptors (IL-11R and IL-6R, respectively). Formation of IL-11/IL-11R and IL-6/IL-6R complexes triggers the recruitment of a homodimer of the ubiquitously expressed signal-transducing β-receptor gp130 (classic signaling). IL-11R and IL-6R can be shed by several proteases, albeit with different preferences and specificities, and these soluble receptors (sIL-11R and sIL-6R) act as agonists and can activate in principle all cells via gp130. ...
Activation of target cells occurs via membrane-bound IL-11 and IL-6 receptors (IL-11R and IL-6R, respectively). Formation of IL-11/IL …
The impact of HLA-G, LILRB1 and LILRB2 gene polymorphisms on susceptibility to and severity of endometriosis
Bylińska A, et al. Mol Genet Genomics 2018. PMID 29234882 Free PMC article.
HLA-G is recognized by KIR2DL4, LILRB1 and LILRB2 receptors on natural killer (NK) and other cells. These receptors are polymorphic, which may affect their activity. ...These results support the role of polymorphisms of HLA-G and its receptors LILRB1 and LILRB2 in susceptibility to endometriosis and its progression....
HLA-G is recognized by KIR2DL4, LILRB1 and LILRB2 receptors on natural killer (NK) and other cells. These receptors are polymo …
Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition
Balaji GR, et al. Nat Commun 2018. PMID 30397201 Free PMC article.
The interaction between natural killer (NK) cell inhibitory receptors and their cognate ligands constitutes a key mechanism by which healthy tissues are protected from NK cell-mediated lysis. ...
The interaction between natural killer (NK) cell inhibitory receptors and their cognate ligands constitutes a key mechanism by which …
Novel multiplex PCR-SSP method for centromeric KIR allele discrimination
Le Luduec JB, et al. Sci Rep 2018. PMID 30291273 Free PMC article.
Allelic diversity of the KIR2DL receptors drive differential expression and ligand-binding affinities that impact natural killer cell function and patient outcomes for diverse cancers. We have developed a global intermediate resolution amplification-refractory mutation system (ARMS) PCR-SSP method for distinguishing functionally relevant subgroups of the KIR2DL receptors, as defined by phylogenetic study of the protein sequences. ...
Allelic diversity of the KIR2DL receptors drive differential expression and ligand-binding affinities that impact natural killer cell …
Effect of Low-Fat Diet in Obese Mice Lacking Toll-like Receptors.
Rau CS, et al. Nutrients 2018. PMID 30304787 Free PMC article.
Background: This study aimed at assessing the effect of a low-fat diet (LFD) in obese mice lacking toll⁻like receptors (Tlr) and understanding the expression and regulation of microRNAs during weight reduction. ...
Background: This study aimed at assessing the effect of a low-fat diet (LFD) in obese mice lacking toll⁻like receptors (Tlr) and unde …
Regulation of cell migration by α4 and α9 integrins
Hight-Warburton W and Parsons M. Biochem J 2019 - Review. PMID 30819933
Integrins are heterodimeric transmembrane receptors that play an essential role in enabling cells to sense and bind to extracellular ligands. ...This review summarises the known shared and specific roles for α4 and α9 integrins and highlights the importance of these receptors in controlling cell migration within both homeostatic and disease settings....
Integrins are heterodimeric transmembrane receptors that play an essential role in enabling cells to sense and bind to extracellular …
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