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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 4
1984 43
1985 92
1986 96
1987 106
1988 97
1989 102
1990 123
1991 123
1992 121
1993 113
1994 144
1995 162
1996 182
1997 178
1998 231
1999 219
2000 214
2001 287
2002 329
2003 324
2004 375
2005 379
2006 504
2007 562
2008 644
2009 658
2010 643
2011 782
2012 780
2013 805
2014 754
2015 747
2016 730
2017 716
2018 668
2019 264
2020 2
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11,943 results
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Page 1
A review of PCSK9 inhibition and its effects beyond LDL receptors.
Dixon DL, et al. J Clin Lipidol 2016 - Review. PMID 27678423
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an integral role in the degradation of low-density lipoprotein receptors (LDL-R), making it an intriguing target for emerging pharmacotherapy. ...Perhaps, more intriguing is the interaction between PCSK9 and non-LDL-R targets, including mediators of inflammation and immunological processes, which remain under intense investigation. ...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an integral role in the degradation of low-density lipoprotein receptors
ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors.
Gordts PL, et al. J Clin Invest 2016. PMID 27400128 Free PMC article.
We determined that a murine-specific ApoC-III-targeting ASO reduces fasting TG levels through a mechanism that is dependent on low-density lipoprotein receptors (LDLRs) and LDLR-related protein 1 (LRP1). ApoC-III ASO treatment lowered plasma TGs in mice lacking lipoprotein lipase (LPL), hepatic heparan sulfate proteoglycan (HSPG) receptors, LDLR, or LRP1 and in animals with combined deletion of the genes encoding HSPG receptors and LDLRs or LRP1. ...
We determined that a murine-specific ApoC-III-targeting ASO reduces fasting TG levels through a mechanism that is dependent on low-density l …
WNT receptor signalling in lung physiology and pathology
Skronska-Wasek W, et al. Pharmacol Ther 2018 - Review. PMID 29458107
WNTs (secreted glycoproteins) interact with various transmembrane receptors and co-receptors to activate signalling pathways that regulate transcriptional as well as non-transcriptional responses within cells. ...In this review we highlight the diverse expression of various WNT receptors and co-receptors in the aforementioned chronic lung diseases and discuss the currently available biologicals and pharmacological tools to modify proximal WNT signalling....
WNTs (secreted glycoproteins) interact with various transmembrane receptors and co-receptors to activate signalling pathways t …
Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions
Wang S, et al. J Biol Chem 2018. PMID 29559555 Free PMC article.
Using a panel of gene-edited isogenic cell line models, we demonstrate that GalNAc-T11-mediated LDLR and VLDLR O-glycosylation is not required for transport and cell-surface expression and stability of these receptors but markedly enhances LDL and VLDL binding and uptake. Direct ELISA-based binding assays with truncated LDLR constructs revealed that O-glycosylation increased affinity for LDL by ∼5-fold. ...
Using a panel of gene-edited isogenic cell line models, we demonstrate that GalNAc-T11-mediated LDLR and VLDLR O-glycosylation is not requir …
Surface aggregation patterns of LDL receptors near coated pits III: potential effects of combined retrograde membrane flow-diffusion and a polarized-insertion mechanism.
Echavarria-Heras H, et al. Theor Biol Med Model 2014. PMID 24885954 Free PMC article.
At first it was considered that LDL receptors in human fibroblasts are inserted at random locations and then transported by diffusion toward coated pits. ...We also project the resulting display of unbound receptors on the cell membrane. We found forms of polarized insertion that could potentially reduce the mean capture time of LDL receptors by coated pits which is controlled by diffusion and uniform insertion. ...
At first it was considered that LDL receptors in human fibroblasts are inserted at random locations and then transported by di …
News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1
van de Sluis B, et al. Curr Opin Lipidol 2017 - Review. PMID 28301372 Free PMC article.
After internalization, the receptors are redirected via recycling endosomes to the cell surface. Several new endocytic proteins that facilitate the endosomal trafficking of LDLR and consequently the clearance of circulating LDL cholesterol have recently been reported. ...
After internalization, the receptors are redirected via recycling endosomes to the cell surface. Several new endocytic proteins that …
Role of Ox-LDL and LOX-1 in Atherogenesis.
Kattoor AJ, et al. Curr Med Chem 2019 - Review. PMID 29737246
Oxidized LDL (ox-LDL) plays a central role in atherosclerosis by acting on multiple cells such as endothelial cells, macrophages, platelets, fibroblasts and smooth muscle cells through LOX-1. ...Currently, novel drug design techniques are used to identify molecules that can bind to LOX-1 and inhibit its activation by ox-LDL. ...
Oxidized LDL (ox-LDL) plays a central role in atherosclerosis by acting on multiple cells such as endothelial cells, macrophag …
11,943 results
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