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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 2
1982 10
1983 7
1984 12
1985 27
1986 48
1987 81
1988 179
1989 333
1990 565
1991 578
1992 710
1993 818
1994 926
1995 850
1996 878
1997 886
1998 978
1999 1018
2000 1069
2001 1045
2002 955
2003 1045
2004 968
2005 1005
2006 1056
2007 1076
2008 1111
2009 1139
2010 1139
2011 1094
2012 1175
2013 1149
2014 1131
2015 1130
2016 1083
2017 1024
2018 905
2019 346
2020 3
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Search Results

27,226 results
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Stimulation of N-methyl-D-aspartate receptors by exogenous and endogenous ligands improves outcome of brain injury.
Biegon A, et al. Curr Opin Neurol 2018 - Review. PMID 30382950
PURPOSE OF REVIEW: The failure of N-methyl-D-aspartate receptor (NMDAR) antagonists as a treatment for human traumatic brain injury (TBI) and stroke, along with preclinical findings of a persistent hypofunctional state of these receptors after brain injury, resulted in a new focus on NMDAR agonists, specifically those acting via the glycine site of the NMDAR. ...
PURPOSE OF REVIEW: The failure of N-methyl-D-aspartate receptor (NMDAR) antagonists as a treatment for human tra …
Positive N-Methyl-D-Aspartate Receptor Modulation by Rapastinel Promotes Rapid and Sustained Antidepressant-Like Effects.
Donello JE, et al. Int J Neuropsychopharmacol 2019. PMID 30544218 Free PMC article.
BACKGROUND: Modulation of glutamatergic synaptic transmission by N-methyl-D-aspartate receptors can produce rapid and sustained antidepressant effects. ...While both rapastinel and ketamine physically target N-methyl-D-aspartate receptors, the 2 molecules have opposing actions on N-methyl-D-aspartate receptors. ...
BACKGROUND: Modulation of glutamatergic synaptic transmission by N-methyl-D-aspartate receptors can produ …
N-methyl-D-aspartate receptor dysfunction by unmutated human antibodies against the NR1 subunit.
Wenke NK, et al. Ann Neurol 2019. PMID 30843274 Free PMC article.
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis related to autoantibody-mediated synaptic dysfunction. ...
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis related to au …
N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells.
Hong J, et al. Neural Plast 2018. PMID 30123246 Free PMC article.
In this work, we determined the distribution of N-methyl-D-aspartate receptors (NMDARs) and their role in the gentamicin-induced pathological changes of cochlear IHC ribbon synaptic elements. ...
In this work, we determined the distribution of N-methyl-D-aspartate receptors (NMDARs) and their role in …
N-Methyl D-aspartate receptor subunit signaling in fear extinction.
Radulovic J, et al. Psychopharmacology (Berl) 2019 - Review. PMID 30238131 Free PMC article.
N-Methyl D-aspartate receptors (NMDAR) are central mediators of glutamate actions underlying learning and memory processes including those required for extinction of fear and fear-related behaviors. ...
N-Methyl D-aspartate receptors (NMDAR) are central mediators of glutamate actions underlying learning and
Anti-N-methyl-D-aspartate receptor encephalitis: A case report.
Li H, et al. Medicine (Baltimore) 2018. PMID 30558047 Free PMC article.
RATIONALE: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an auto-immune and paraneoplastic encephalitis with prominent neuropsychiatric manifestations. The N-methyl-D-aspartate receptor is located in the forebrain and hippocampus and plays a role in learning and memory. PATIENT CONCERNS: A 29-year-old female patient with anti-NMDAR encephalitis, was reported and we also reviewed the literature and summarised the characteristics of the cases. ...
RATIONALE: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an auto-immune and paraneoplastic enc …
Chronic antipsychotic treatment differentially modulates protein kinase A- and glycogen synthase kinase 3 beta-dependent signaling pathways, N-methyl-D-aspartate receptor and γ-aminobutyric acid A receptors in nucleus accumbens of juvenile rats.
Pan B, et al. J Psychopharmacol 2018. PMID 30136620
RESULTS: In the nucleus accumbens, all three drugs differentially increased N-methyl-D-aspartate and γ-aminobutyric acid A receptor expression. ...Correlation analysis indicated that antipsychotics might modulate N-methyl-D-aspartate receptors via glycogen synthase kinase 3 beta-β-catenin signaling and/or cAMP-responsive element-binding protein 1 activation. ...
RESULTS: In the nucleus accumbens, all three drugs differentially increased N-methyl-D-aspartate and γ-aminobuty …
N-methyl-D-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain.
Medeiros P, et al. Neurochem Res 2019. PMID 31317507
Thus, the aim of the present work was to investigate the participation of the prelimbic (PrL) area of the mPFC in neuropathic pain as well as the role of N-methyl D-aspartate (NMDA) glutamate receptors in neuropathic pain induced by a modified sciatic nerve chronic constriction injury (CCI) protocol in Wistar rats. ...These findings suggest that NMDA receptors in the PrL cortex participate in enhancing the late phase of mechanical allodynia after NMDA-induced increases and LY235959-induced decreases in allodynia 21 days after CCI. ...
Thus, the aim of the present work was to investigate the participation of the prelimbic (PrL) area of the mPFC in neuropathic pain as well a …
Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors.
Fu H, et al. J Med Chem 2019 - Review. PMID 30110164 Free PMC article.
Ionotropic glutamate receptors (iGluRs) mediate excitatory neurotransmission within the mammalian central nervous system. iGluRs exist as three main groups: N-methyl-d-aspartate receptors (NMDARs), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), and kainate receptors. ...These approaches, if successful as PET tracers, may provide fundamental knowledge to understand the roles of iGluR receptors under physiological and pathological conditions....
Ionotropic glutamate receptors (iGluRs) mediate excitatory neurotransmission within the mammalian central nervous system. iGluRs exis …
27,226 results
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