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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 9
1991 7
1992 6
1993 24
1994 30
1995 40
1996 65
1997 89
1998 91
1999 127
2000 173
2001 210
2002 215
2003 239
2004 300
2005 340
2006 387
2007 425
2008 492
2009 498
2010 536
2011 657
2012 617
2013 679
2014 721
2015 655
2016 568
2017 522
2018 522
2019 211
2020 3
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8,575 results
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Page 1
Congenital diseases caused by defective O-glycosylation of Notch receptors.
Tashima Y and Okajima T. Nagoya J Med Sci 2018 - Review. PMID 30214079 Free PMC article.
These O-glycan modifications are important for Notch function. Defects in O-glycosylation affect Notch-ligand interaction, trafficking of Notch receptors, and Notch stability on the cell surface. ...In this review, we discuss O-glycosylation of Notch receptors and congenital human diseases caused by defects in O-glycans on Notch receptors....
These O-glycan modifications are important for Notch function. Defects in O-glycosylation affect Notch-ligand interaction, tra …
Notch and Neurogenesis.
Engler A, et al. Adv Exp Med Biol 2018 - Review. PMID 30030829
In this chapter, we will discuss the role of Notch signaling in the control of neurogenesis and regeneration in the embryo and adult. Notch-dependence is a common feature among NSC populations, we will discuss how differences in Notch signaling might contribute to heterogeneity among adult NSCs. ...
In this chapter, we will discuss the role of Notch signaling in the control of neurogenesis and regeneration in the embryo and adult. …
Notch Signaling in the Tumor Microenvironment.
Meurette O and Mehlen P. Cancer Cell 2018 - Review. PMID 30146333 Free article.
The Notch signaling pathway regulates many aspects of cancer biology. Most attention has been given to its role in the transformed cell. ...We also address the consequences of the Notch-TME involvement from a therapeutic perspective....
The Notch signaling pathway regulates many aspects of cancer biology. Most attention has been given to its role in the transformed ce …
Mechanisms of Notch signaling: a simple logic deployed in time and space.
Henrique D and Schweisguth F. Development 2019 - Review. PMID 30709911 Free article.
Most cells in our body communicate during development and throughout life via Notch receptors and their ligands. Notch receptors relay information from the cell surface to the genome via a very simple mechanism, yet Notch plays multiple roles in development and disease. ...Here, we review recent findings on the core Notch signaling mechanism and discuss how spatial-temporal dynamics contribute to Notch signaling output....
Most cells in our body communicate during development and throughout life via Notch receptors and their ligands. Notch
NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies.
Kelliher MA and Roderick JE. Front Immunol 2018 - Review. PMID 30967879 Free PMC article.
The NOTCH (1-4) family of receptors are highly conserved and are critical in regulating many developmental processes and in the maintenance of tissue homeostasis. ...In addition, NOTCH receptors and ligands are being utilized to improve the generation and specificity of T-cells for adoptive transplant immunotherapies. ...
The NOTCH (1-4) family of receptors are highly conserved and are critical in regulating many developmental processes and in th …
The bone marrow microenvironment at single-cell resolution
Tikhonova AN, et al. Nature 2019. PMID 30971824 Free PMC article.
Among the stress-induced changes, we observed that vascular Notch delta-like ligands (encoded by Dll1 and Dll4) were downregulated. ...
Among the stress-induced changes, we observed that vascular Notch delta-like ligands (encoded by Dll1 and Dll4) were downregulated. . …
The Notch Pathway in Breast Cancer Progression.
Kontomanolis EN, et al. ScientificWorldJournal 2018 - Review. PMID 30111989 Free PMC article.
Notch signaling controls the differentiation of breast epithelial cells during normal development. Studies confirm that the Notch pathway has a major participation in breast cancer progression through overexpression and/or abnormal genetic type expression of the notch receptors and ligands that determine angiogenesis. ...Inhibition of Notch receptors and ligands provides innovative therapeutic results and could become the therapy of choice in the next few years, even though further research is needed to reach safe conclusions....
Notch signaling controls the differentiation of breast epithelial cells during normal development. Studies confirm that the Notch
Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.
Zhu C, et al. Sci Transl Med 2018. PMID 30463916 Free PMC article.
In a cross-sectional study, we found that OPN explains the positive correlation between liver Notch activity and fibrosis stage in patients. Further, we developed a Notch inhibitor [Nicastrin antisense oligonucleotide (Ncst ASO)] that reduced fibrosis in NASH diet-fed mice. ...
In a cross-sectional study, we found that OPN explains the positive correlation between liver Notch activity and fibrosis stage in pa …
Notch and Senescence.
Hoare M and Narita M. Adv Exp Med Biol 2018 - Review. PMID 30030833
We also highlight the complex physical and functional interplay between Notch and p53, critical to both senescence and cancer. Understanding the interplay between Notch, p53 and senescence could allow us develop the therapeutics of the future for cancer and ageing....
We also highlight the complex physical and functional interplay between Notch and p53, critical to both senescence and cancer. Unders …
Structural basis of Notch recognition by human γ-secretase.
Yang G, et al. Nature 2019. PMID 30598546
Aberrant cleavage of Notch by γ-secretase leads to several types of cancer, but how γ-secretase recognizes its substrate remains unknown. ...The transmembrane helix of Notch is surrounded by three transmembrane domains of PS1, and the carboxyl-terminal β-strand of the Notch fragment forms a β-sheet with two substrate-induced β-strands of PS1 on the intracellular side. ...
Aberrant cleavage of Notch by γ-secretase leads to several types of cancer, but how γ-secretase recognizes its substrate remains unkn …
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