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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1978 8
1979 17
1980 17
1981 19
1982 16
1983 15
1984 18
1985 23
1986 34
1987 49
1988 35
1989 49
1990 57
1991 77
1992 78
1993 107
1994 130
1995 137
1996 188
1997 196
1998 260
1999 283
2000 302
2001 354
2002 355
2003 416
2004 589
2005 585
2006 683
2007 706
2008 763
2009 839
2010 879
2011 1007
2012 1054
2013 1068
2014 1058
2015 1090
2016 1006
2017 986
2018 997
2019 429
2020 12
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15,436 results
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Page 1
KRAB zinc finger proteins.
Ecco G, et al. Development 2017 - Review. PMID 28765213 Free article.
Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcriptional regulators in higher vertebrates. ...
Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcriptional regulators in higher vertebr …
Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex.
Adams GE, et al. Biochem J 2018 - Review. PMID 30552170 Free PMC article.
At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound repressor proteins to facilitate local histone deacetylation and transcriptional repression. ...Sin3 appears to have properties of a co-repressor, co-activator and general transcription factor, and has thus been termed a co-regulator complex. ...
At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-repressor complex, that is, a multi-protei …
Autophagy regulates lipid metabolism through selective turnover of NCoR1.
Saito T, et al. Nat Commun 2019. PMID 30952864 Free PMC article.
However how selective autophagy regulates metabolism remains largely uncharacterized. Here we show that a deficiency in selective autophagy is associated with suppression of lipid oxidation. ...Mechanistically, nuclear receptor co-repressor 1 (NCoR1), which interacts with PPARα to suppress its transactivation, binds to the autophagosomal GABARAP family proteins and is degraded by autophagy. ...
However how selective autophagy regulates metabolism remains largely uncharacterized. Here we show that a deficiency in selective aut …
The role of ASXL1 in hematopoiesis and myeloid malignancies
Asada S, et al. Cell Mol Life Sci 2019 - Review. PMID 30927018
Studies using ASXL1-depleted human hematopoietic cells and Asxl1 knockout mice have shown that deletion of wild-type ASXL1 protein leads to impaired hematopoiesis and accelerates myeloid malignancies via loss of interaction with polycomb repressive complex 2 proteins. ...
Studies using ASXL1-depleted human hematopoietic cells and Asxl1 knockout mice have shown that deletion of wild-type ASXL1 protein leads to …
Prohibitins
Tatsuta T and Langer T. Curr Biol 2017. PMID 28697355 Free article.
Tatsuta and Langer introduce prohibitins, membrane scaffolding proteins found predominantly in mitochondria....
Tatsuta and Langer introduce prohibitins, membrane scaffolding proteins found predominantly in mitochondria....
PEG3 Interacts with KAP1 through KRAB-A
He H, et al. PLoS One 2016. PMID 27898713 Free PMC article.
As predicted, the PEG3 protein was co-immunoprecipitated with KAP1, a co-repressor that interacts with KRAB-A. A series of follow-up experiments further demonstrated that the exon 7 of PEG3 is indeed responsible for its physical interaction with KAP1. ...Overall, the current study identifies PEG3 as a KRAB-containing zinc finger protein that interacts with the co-repressor protein KAP1....
As predicted, the PEG3 protein was co-immunoprecipitated with KAP1, a co-repressor that interacts with KRAB-A. A series of follow-up …
ZEB1-regulated inflammatory phenotype in breast cancer cells
Katsura A, et al. Mol Oncol 2017. PMID 28618162 Free PMC article.
Antibody array and ELISA experiments confirmed that ZEB1 controlled the production of the IL-6 and IL-8 proteins. The secretory proteins regulated by ZEB1 enhanced breast cancer cell proliferation and tumor growth. ...
Antibody array and ELISA experiments confirmed that ZEB1 controlled the production of the IL-6 and IL-8 proteins. The secretory pr
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